1.The treatment of EMG biofeedback for 61 neurotic outpatients
Chinese Mental Health Journal 1988;0(06):-
Two groups of neurotic outpatients were compared in their outcome afterfrontal EMG biofeedback treatment with Jacobson progressive relaxation at home.The firstneurotic group consisted of 42 patients and treated once every two days for four weeks whilethe second group consisted of 19 cases and treated every day but for only two weeks.Similarily satisfactory clinical effects and same trends of change in various physiological indexof EMG and clinical symptons were observed,between these two groups.No relationship wasfound between patient's personality characteristc and clinical effects.In a four follow up,2/3patients reported a continuous satisfactory outcome.
2.The antiinflammatory effects of an adenosine
Chinese Pharmacological Bulletin 1998;0(S1):-
Adenosine is an endogenous purine uncleoside released by cells as part of the normal metablic mechinary. During inflammation, massive ATP degradation increases the local adenosine concentration to the micromolar range, at the range, adenosine extert potent antiinflammatory rale. In vivo or in vitro experiments, the addition exogenious adenosine, its analogues and inhibition of its degradation attenuate injury of animal models of inflammation. Antiinflammatory mechinasms involve in;(1)Adenosine inhibites neutrophil function in vitro, including chemotaxiz, adhesion, phogocytosis, and oxygen radical generation. (2) Decrease the expression of collagenase, and reduce the amount of collagenase. (3)Blocking neutrophil adhesion to the endothelium mediated by L-selectin and ftrEategrin. (4)inhibition activated humanmonocytes and macrophage secreting cytokins. (5) Adenosine enhances IL-10 secretion by human monocytes. (6)inhibition of immune response and so on. Relation with nonsteroidal antiinflammatory drugs (NSALDs) includes:(1)MTX and SASP inhibit the activity of 5-aminoimidazole-4-carboxam-ide ribonucleotide (AICAR) transformylase resulting in increased local adenosine concentraton. (2) Azathioprine and its potential metabolite inhibits adenosine kinase, diminish AMP formation by adenosine. In conclusion, the existance of a novel class of antiinflammatory agents, affects adenosine metabolism and may be a useful antiinflammatory drug as well.
3.Sulfony lureas and ischemic stroke
International Journal of Cerebrovascular Diseases 2013;(1):65-68
Sulfonylureas are one of the major oral drugs for the treatment of type 2 diabetes mellitus.Studies in recent years have shown that such drugs have the effect of independent of reducing blood sugar on ischemic stroke.This effect is mainly associated with the combination of sulfonylurea receptor 1 (SUR1) to regulate of ATP-sensitive non-selective cation channels.
5.Treatment of metacatpal and phalangeal fractare with AO mini-plate
Chinese Journal of Primary Medicine and Pharmacy 2006;0(03):-
Objective To investigate the freatment outcome of internal fixation of the metacarpal and phalanx fracture using the pure fitanium mini plate.Methods 42 cases(78 lesions) of metacarpal and phalanx fracture were involved.Internal fixation with custom made pur titanium mini plate was done.Results Postoperative follow up rauged from 3 to 14 months and the fracture was healed in 42 cases.The bone union of roantgenographic eridence was 6 to 12 weeks.According to the functional evaluation of TAM ascles the excellent and good rate was 85.7%.Conclusion The AO mini-plate in treatment of the metacarpal and phalax fracture has a firm fixation.It is an optimal strategy for metarcarpal and phalanx fracture.
6.Toxicity of Methylmercury on Primary Cultured Rat Astrocyte
Chinese Journal of Rehabilitation Theory and Practice 2008;14(5):437-439
Objective To study the mechanism of toxicity of methylmercury on primary cultured SD rat astrocyte.Methods Treat primary cultured SD rat astrocyte with methylmercury.Determine the level of cyto-oxidation redoxin with High Performance Liquid Chromatography(HPLC).Western-blot was applied to examine the protein expression of nuclear factor erythroid 2 related factor 2(Nrf2).Results With the increase of the concentration of methylmercury,the redoxin level of astrocyte was apparently decreasing.When the concentration of methylmercury was at a low level,the expression of Nrf2 was increasing with the increase of the methylmercury concentration.When the concentration of methylmercury was at a high level,the expression of Nrf2 was decreasing with the increase of the methylmercury concentration.Conclusion The toxicity of methylmercury on primary cultured SD rat astrocyte can be realized through altering the function of GSH and Nrf2.
7.The clinical significance of NO expression in the phase of periodic paralysis stoke
Jiyang QI ; Daping HU ; Hongfei YUAN
Clinical Medicine of China 2001;0(07):-
Objective To find out the effect of NO on the stroke of periodic paralysis.Methods Blood potassium,NO and NOS were measured in patients with hypokalemic periodic paralysis during paralysis stroke and after muscle power recovered.The relationship between NO and NOS and paralysis in the different phase was observed.Results NO and NOS decreased obviously in the phase of paralysis,which tended to be normal with recovering of blood potassium and muscle power after treatment.The change of NO was positively correlated with the decreasing degree of blood potassium(r=0.3511,P
8.The Prevalence of Premenstrual Dysphoric Disorder in Female College Students
Jiyang PAN ; Lixin YANG ; Huajun LIANG
Chinese Mental Health Journal 1991;0(04):-
0.05).Conclusions: (1) The more severe of learning stress, the higher level of PMDD. (2) There was no difference in anxiety and depression between the students who suffered from PMDD and the who didn't. (3) The students who suffered from PMDD had more psychosomatic symptoms.
9.Inhibiting ERK1/2 pathway reduces brain edema and down-regulates matrix metalloproteinase-9 expression after subarachnoid hemorrhage in rats
Jiyang AN ; Haitao JIANG ; Jie CHEN ; Jiangtao XIE
International Journal of Cerebrovascular Diseases 2011;19(2):115-121
Objective To study the effect of extracellular signal-regulated kinase1/2 (ERK1/2)inhibitor U0126 on matrix metalloproteinase-9(MMP-9)in brain tissue after subarachnoid hemorrhage(SAH)in rats and to investigate the action mechanisms of ERK1/2 and M M P-9 in blood-brain barrier(BBB)injury and brain edema after SAH.Methods Seventy-two male Sprague-Dawley rats were randomly divided into four groups:SAH model,sham operation,U0126 intervention,and vehicle groups.A SAH model was induced by injection of autologous blood into cisterna magna once.The dry-wet weight method was used to detected brain tissue water content in order to evaluate cerebral edema.BBB permeability was evaluated by the Evans blue extravasation method.The immunohistochemical method was used to detect the expression of MMP-9 and phosphorylated ERK1/2.Results The expression of phosphorylated ERK1/2 and MMP-9 was lower in the sham operation group.The expression of both was up regulated at 24 hours after SAH.The brain water content and Evans blue content also increased.U0126 treatment decreased the phosphorylation of ERK1/2 and the expression of MMP-9,improved the BBB permeability,and alleviated brain edema.Conclusions MMP-9 is involved in the pathophysiological processes of early BBB injury and brain edema aft er SAH.ERK1/2 pathway may play a vital role in the expression of MMP-9.U0126 may protect BBB and reduce brain edema after SAH by inhibiting the phosphorylation of ERK1/2.
10.Effect of cognitive dysfunction of gangliosides on in the treatment of the patients with traumatic brain injury intraoperative and postoperative
Jiyang FANG ; Xuliang JIN ; Wuquan WU
Chinese Journal of Biochemical Pharmaceutics 2017;37(8):393-394
Objective To study the effect of cognitive dysfunction of gangliosides on in the treatment of the patients with traumatic brain injury intraoperative and postoperative. Methods From February 2015 to August 2016, 100 patients with cognitive dysfunction after operation were randomly divided into two groups, the control group and the experimental group, 50 cases in each group. The control group were received routine treatment, including medication, brain rehabilitation, and dehydration and intracranial pressure reduction. At this basis, the experimental group were treated with gangliosides. The clinical indexes in the experimental group and the control group were compared and analyzed. Results The cure rate was 90% in the experimental group, and 54% in the control group. The difference in the two groups has statistically significant (P<0.05). Before treatment, there was no significant difference of the MMSE in the two groups. After treatment, the MMSE score in the experimental group was (28.34 ± 4.12) points, and the score of MMSE in the control group was (22.19 ± 5.49) points. The difference in the two groups has statistically significant (P<0.05). Conclusion The effect of cognitive dysfunction is better which ganglioside was used on the treatment of the patients with traumatic brain injury intraoperative and postoperative, and the cure rate is higher. It has the significance of further popularization and application.