With the rapid development of our country,people are facing more and more psychological problems.It has been demonstrated that persistent stress and depression,which leads to continuously elevated levels of stress hormones,might eventually compromise host defenses against bacterial or viral infection while increasing the reoccurance of autoimmunity and the incidence of malignancy/metastasis.Even though the molecular mechanisms by which chronic psychological stress inhibits the effector subsets in the immune system have been partially disclosed,it remains elusive whether chronic psychological stress also affects the regulatory subsets and if yes,what are the underlying mechanisms.Here,we review the findings in this field.

Adrenal insufficiency is a common complication in sepsis patients, with a higher morbidity in septic shock patients.Adrenal insufficiency is closely related to coagulation disorders, inflammatory mediators and glucocorticoid resistance.The mechanisms of adrenal insufficiency in sepsis have not been discussed clearly.In the present review we detail the mechanisms of adrenal insufficiency that are active during sepsis.

Objective To explore the the effect of Omeprazole combined with operation on treatment of rupture of small intestine in closed abdominal injury.Methods From June 2014 to December 2014,64 cases in Xinchang county people's hospitalwith rupture of small intestine in closed abdominal were divided into the treatment group and the control group,32 cases in each group.The control group were treat with surgery,the treatment group were given surgery combined with Omeprazole.The total effective rate,quality of life,the recovery time of bowel sound and the echaust time in the two groups were compared.Results The total effective rate(90.6％,29/32)in the treatment group was significantly higher than that in thecontrol group(75.0％,24/32),the difference is significant(P< 0.05).The life index in the treatment group is significantly better than that in the control group(P<0.05).The recovery time of bowel sound in the treatment group(15.3±2.6)h,is shorter than that in the control group(23.8±6.8)h; the exhaust time(23.6±2.2)h in the treatment group is lower than that in the control group(32.3±4.6)h,the differencesis statistically significant(P< 0.05).Conclusion It can significantly improve the effect and postoperative indexes which omeprazole combined with surgical treatment on the treatment of rupture of small intestine in closed abdominal injury,Itshould be widely promoted.

OBJECTIVE:To investigate the first-pass effect and mechanism of vitexin-4′-O-glucoside(VG)in rats so as to pro-vide a basis for new drug development. METHODS:10 SD rats were divided into a group of hepatic portal venous administration and a group of femoral venous administration,which respectively received VG iv at superior mesenteric vein and femoral vein,and then metabolic rate was calculated by finding out the AUC of VG in the rats’livers. 15 SD rats were divided into a group of gastric infusion,a group of intestinal infusion and a group of hepatic portal venous infusion,which respectively received VG by infusion at gastric fundus and duodenum and iv at superior mesenteric vein,and then metabolic rate was calculated by finding out the AUC of VG in the rats’stomachs and intestines. 15 SD rats were divided into a group of intestinal infusion,a group of femoral venous administration and a group of normal saline. At 10 min before administration,the former two groups were given by infusion vera-pamil injection(60 ml/kg),the substrate of CYP3A and P-glycoprotein(P-gp);and the group of normal saline were given by infu-sion of isometric normal saline,and then the rats were given VG as above to observe the effect of verapamil on intestinal absorp-tion of VG. RESULTS:The metabolic rates of VG in the liver,stomach and intestine were 54.9%,1.7% and 91.9% respectively. After infusion of verapamil,slight increase in AUC of VG was found in the rats in the group of intestinal infusion. CONCLU-SIONS:The first-pass effects in the liver and intestine are the main factors related to the low bioavailability of VG. Based on pre-liminary judgment,VG is the substrate of intestinal CYP3A and/or P-gp.

Objective The 47 myocardial infarction patients (male 41, female 6, average ages 55 7?9 7 years) with silent myocardial ischemia (type Ⅱ SMI) were chosen The relationship was studied between the history of myocardial infarction (MI)and the degree of coronary arterial stenosis and the residual degree of stenosis after percataneous transluminal coronary angioplasty (PTCA) Methods All patients with MI were performed with exercise testing electrocardiogram to investigate the degree of myocardial ischemia The patients were also studied the degree of coronary arterial stenosis before and after PTCA Results The results showed before PTCA, the degree of the patients′ coronary arterial stenosis with a period of no more than three months of MI was higher than that of those patients′ with a period of over three months( P

Aim To investigate the signaling basis of the biological effects of IL-6 in U937 cells. Methods We determined the effect of IL-6 on the growth and differentiation of U937 cells and the effect of IL-6 on the activation of nuclear factors in U937 cells. Results IL-6 induced macrophage differentiation of U937 cells. Differentiated cells had strengthened ANAE (acid naphthyl acetate esterase)and NBT(nitroblue tetrazolium)-reducing activities and CD54 expression was upregulated. STAT3 could be remarkably activated by IL-6 in U937 cells and STAT3 activity was dependent on dose and time course of IL-6 treatment. However, NF-IL6,NF-κ B, AP-1 and other STAT members were not activated by IL-6. Conclusion IL-6 might induce terminal differentiation of U937 cells via JAK-STAT3 pathway.

Objective:To evaluate effect of simvastatin on neurons autophagy in the hippocampus following intracerebral hemorrhage( ICH) in rats.Methods:All rats were divided randomly into sham group;ICH group and SIM group.The rat model of ICH was made by injection of Ⅶ type collagenase.The behavioral changes were evaluated with Garcia′s neurologic deficit score.Wet-dry weight method was used to evaluate brain edema.Additionally,localization of LC3 protein was determined by immunohistochemistry, and the expression of Beclin-1 in hippocampus was tested by Western blot methods.Results: Compared with ICH group,simvastatin treatment after ICH significantly improved neurologic deficit score ( P<0.05 ) , reduced the water content of brain tissue ( P<0.05 ) , inhibited the expression of LC3 and Beclin-1 protein(P<0.05).Conclusion:Our findings indicated that administration of simvastatin had neuroprotective effects in ICH rat model,which could be involved in inhibiting activation of autophagy in the hippocampus,finally reducing brain edema and neurobehavioral deficit.

Objective To explore the clinical effect of traditional Chinese medicine and western medicine in treatment of patients with angina pectoris. Methods 120 cases with angina pectoris admitted in the Fourth Hospital of Baotou City from May 2012 to August 2013 were randomly divided into treatment group (n=60)and control group (n=60). All patients were given secondary prevention of coronary heart disease,and besides this, treatment group were added nitrates medications and traditional Chinese medicine treatment,while control group were only given nitrates medications.The treatment course was 14 days. The efficacy of angina pectoris,nitroglycerin loss rate and electrocardiogram efficacy were compared and the safety were evaluated between two groups. Results The efficacy of angina pectoris in treatment group was 90.00%,while control group was 71.67%,the difference was statistically significant(P<0.05 ). ECG efficiency in treatment group was 68.33%,while control group was 48.33%,the difference was statistically significant(P<0.05 ). The reduction of nitroglycerin was 86.67%,while control group was 61.67%,the difference was statistically significant(P<0.05). In addition,there were no adverse reaction in two groups. Conclusion Compared with nitrates medications,combined Chinese and Western medicine in treatment of patients with angina pectoris on basis of secondary prevention of coronary heart disease has better therapeutically effective rate.

Constriction, Pathologic ; Coronary Angiography ; Coronary Stenosis ; complications ; Coronary Vessels ; Humans ; Syphilis, Cardiovascular ; complications

OBJECTIVE:To provide reference for rational prophylactic application of antibiotics in perioperative period of per-manent cardiac pacemaker implantation. METHODS:600 cases performed permanent cardiac pacemaker implantation in 2010(be-fore rectification),2012(during rectification)and 2014(after rectification)were randomly sampled from our hospital,and divided into control group,intervention group one and intervention group two. The prophylactic application of antibiotics was investigated and analyzed in 3 groups. RESULTS:For control group,intervention group one and intervention group two,the rates of rational type selection of antibiotics for prophylactic use were 7.25%,31.00% and 91.96%,respectively. The rates of rational medication timing of antibiotics for prophylactic use were 0,100% and 100%;average duration of prophylactic use decreased from (3.6 ± 1.2)d before intervention to(1.1±0.5)d and(1.0±0.2)d. There was no statistical significance in the incidence of postoperative infection(P>0.05). Compared with control group,average drug cost,antibiotics cost and drug ratio decreased significantly in in-tervention group,with statistical significane (P<0.05). CONCLUSIONS:Antibiotics special rectification is effective and improve the rational application of antibiotics in our hospital.