Objective To observe the clinical effect of Oxygen Atomization Inhalation combinated with Tra -ditional Chinese Medicine (TCM) in the treatment of capillary bronchitis .Methods 82 Children with capillary bronchitis were divided into Observation Group (42 cases) and contral group (40 cases).Cases in the Observation Group underwent TCM Agreement medicinal broth and oxygen atomization inhalation , while cases in the contral group underwent Ribavirin atomization .The symptoms of disappear time of signs , clinical effect and adverse circumstance were observed.Results The total efficiency of the observation group was 95.2%, 80% in the contral group.The antifebrile time, disappear time of cough and dyspnea , of the observation group were better than that in the compari -son group.The difference was statistical significant (p <0.05).There was no obvious adverse reactions during the treating periods.Conclusion The clinical effect of Oxygen Atomization Inhalation with Traditional Chinese Medicine (TCM) Agreement Medicinal Broth on capillary bronchitis is confirmed , and the effect of Relieving symptoms , signs quickly and shorten disease time is obviously better than Pure western medicine treatment .In addition, the adverse reactions caused by medicine is also very small ,which is worth promoting for clinical application .

Objective To observe the bipolar radiofrequency ablation maze procedure (BRAMP) combined with heart valve replacement for rheumatic heart disease (RHD) complicated with atrial fibrillation (AF), and discuss the curative effect of the new operation method. Methods Fifteen patients with RHD complicated with AF were treated with heart valve replacement and BRAMP (treatment group). At the same time, 15 patients with RHD complicated with AF were only heart valve replacement without BR AMP(control group). Results Treatment group were all cured, and they had the sinoatrial rhythm after operation.Followed up 6 months, 14 patients maintained sinus rhythm,one had AF occasionally. In control group, 13 patients had AF after operation,2 patients had the sinoatrial rhythm after operation, but they tumed to AF one or two days later,and amiodarone hydrochloride had no effect to them. The two groups had obvious differences in the length of left atria, the length of left ventricle, the size of the heart, the function of the heart and LVEF before and after operation (P ＜ 0.01 or ＜ 0.05). But in treatment group, the length of left atria and the size of the heart had obvious difference after operation compared with control group [ (31.06 ± 2.28 ) mm vs. (36.16 ±2.23) mm,t = 11.645,P =0.002; (50 ±9)% vs. (56 ± 10)% ,t =8.052,P =0.008].Conclusion Compared with the operation that heart valve replacement without BRAMP,BRAMP is simple and little, should be promising.

Objective To discuss the effect of azithromycin on the airway inflammation in children at high risk for asthma by detecting the serum concentration change of eosinophil cationic protein(ECP), intedeukin-8(IL-8) and nitrogen oxide(NO), and also to explore the effect of azithromycin on secondary prevention of asthma. Methods Two hundred and twenty three cases of primary asthmatic attack with atopy (eczema, family asthmatic history) were collected and divided into four groups(group A, B,C,D) after asthmatic symptoms relief, group A was taken orally with azithromycin(5mg/kg Biw), group B was inhaled budesonide(0.5mg Bid), group C was taken orally with singulair (4mg qN),and group D was only given with symptomatic treatment. The vein blood was sampled on the first day in hospital, before and after medication respectively when treatment of three months was completed. Serum concentration of ECP and IL-8 was obtained by ELISA methods, and NO was measured by nitric acid enzyme reduction method. Clinic service and telephone follow-up was taken for one year. Results After three monthes intervention, there was significant difference in the serum concentration of ECP, IL-8 and NO at group A, B, C compared with group D( P<0.01 ). There was no significant difference in decrease of ECP and NO between group A and B( P > 0.05), but decrease of ECP and NO in group C was significant difference compared with group A( P<0.01). The serum concentration of IL-8 in each group was obviously decreased especially in group A, and difference was obvious between group A and group B,C( P<0.01). There was no significant difference in the cases of asthma recurrence within three months and asthmatic recurrence within one year between group A and group B, group C and group D respectively. Conchlsions (1)The medication of azithromycin might result to decrease the serum concentration of ECP and NO, especially for IL-8 in children at high risk for asthma. (2)The effects of azithromycin on change of ECP and NO in children at high risk for asthma were similar to budesonide, but different with montelukast, while the inhabitant effects of IL-8 were different with inhaled steroid hormone and leukotriene receptor obviously. (3)There was some valid contribution of azithromycin actting on the secondary prevention of asthma in our investigation.

0bjective To analyze the factors related tO the changes of liver pathology in hepatitis B e antigen (HBeAg) negative chronic hepatitis B (CHB) patients.Methods Two hundred and eighty-eight HBeAg negative CHB patients were enrolled.Bivariate Pearson correlation was employed to analyze the correlation of different age,gender,alanine aminotransferase (ALT) level,the immunohistochemistry results of hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) in liver tissue with hepatitis B virus (HBV) DNA level,changes of liver pathology.Results The inflammation grades and fibrosis stages of livertissuesinmale were 1.72±1.23 and 1.71±1.24,respectively;1.25±1.39 and 1.21±1.40 in female,respectively,which were significantly different (t=2.398,t-2.551;both P40 years old were all significantly higher than those<40 years old(t一2.060,t一2.536,t=2.808;all P<0.05).In patients with normal ALT levels,75 cases (52.03%) showed HBV DNA level≤1×103 copy/mL,56(38.89%) showed≥G2 of liver tissues; the ALT level and inflammation grade of liver tissues was significantly correlated(r:O.244,P-O.004).In patients with elevated ALT 1evels,42 cases (31.57%) showed HBV DNA level≤1×10s copy/mL,89 (66.92%) showed≥G2 of liver tissues; the ALT level and inflammation grade of liver tissues was not significantly correlated (r=0.007,P=0.939) .The inflammation/fibrosis of liver tissues,HBV DNA levels in patients with both HBsAg and HBcAg positive in liver tissues were significantly higher than those in other patients (P

Objective To study effects of low molecular weight heparin on liver fibrosis and the serum levels of TGF-?_1 in patients with chronic hepatitis B virus.Methods 45 patients with chronic hepatitis B virus were randomized into control group(the routine strategy)and trial group(the routine strategy + low molecular weight heparin).The period of treatment is 3 weeks.Serum hepatic fibrosis indices before and after heparin treatment were examined by RIA,the levels of serum TGF-?_1 before and after heparin treatment were examined by ELISA.Results Hepatic functions became significantly better in trial groups,serum PⅢP and type IV collage levels and the levels of serum TGF-?_1 in trial group decreased significantly after treatment.Conclusions The mechanism of anti-fibrosis action of LMWH may inhibited production of TGF-?_1 in patients with HBV.

Objectives To explore and compare the clinical characteristics and risk factors for mortality between patients with artificial quartz stone silicosis and those with classic silicosis. Methods A total of 48 patients with artificial quartz stone silicosis (experiment group) and 98 patients with classic silicosis (control group) were recruited as the research subjects using the convenience sampling method. Data of clinical symptoms, laboratory tests, high-resolution computed tomography (HRCT), and pulmonary pathology of the research subjects were retrospectively analyzed. The Cox proportional hazards regression model was used to analyze the influencing factors on the survival time of silicosis patients. Results Patients in the experiment group had shorter years of dust exposure, latency period and time since last exposure than those in the control group (all P<0.01). The positive rate of anti-nuclear antibodies and the expression of neuron-specific enolase in the experiment group were higher than those in the control group (39.6% vs 10.2%, median： 28.44 vs 16.25, both P<0.01). The PaO₂ levels in the experiment group were lower than those in the control group (median： 66.0 vs 89.0, P<0.01). The patients in the experiment group had lower vital capacity, inspiratory reserve volume, forced expiratory volume in the first second (FEV₁), forced vital capacity (FVC), and carbon monoxide diffusion capacity compared to the control group (all P<0.05), but the maximal expiratory flow in 75% vital capacity was higher than the control group (P<0.05). Compared with the control group, patients in the experiment group had the presence of ground-glass opacity (GGO) in both lungs, aggregation and fusion of subpleural nodules, and gradual formation of progressive massive fibrosis (PMF), with higher potential of pneumothorax. Within 5 years after diagnosis, the mortality of patients in the experiment group was higher than that in the control group (27.1% vs 4.1%, P<0.01). The Cox regression model analysis results showed that patients with nodule aggregation on lung HRCT images had a higher risk of mortality than those without nodule aggregation, and lower lung function including vital capacity, FVC, FEV₁ and maximum expiratory flow in 25% vital capacity had higher risk of reduced survival time (all P<0.05). Conclusion Compared with patients with classic silicosis, patients with artificial quartz stone silicosis have higher level of serum neuron-specific enolase, increasing the risk of autoimmune diseases. Pulmonary imaging features in patients with artificial quartz stone silicosis include GGO, PMF and susceptibility to pneumothorax, and rare calcification of mediastinal lymph nodes, leading to a higher mortality rate within 5 years after diagnosis.

Objective To explore the CT imaging features of artificial stone?agglomerated quartz associated silicosis. Methods A total of 37 cases confirmed with artificial stone?agglomerated quartz associated silicosis from December 2016 to August 2018 and 38 cases confirmed with traditional classical silicosis at the same period were retrospectively reviewed.The clinical characteristics(including gender, age and working age)and the imaging features(including the nodule features, ground glass opacity, merging features, consolidation, secondary changes, etc.)of the two groups were recorded. The variables including the imaging findings between the two groups were analyzed by Fisher exact test. Results Of all the cases, there were bilateral diffuse small nodules which distributed with upper?zone predominance. Small nodules can merge together and form mass shadow. The complications such as lymphadenopathy, calcification, emphysema/pneumatocele, pulmonary interstitial fibrosis could also be found. Among the various imaging features, the presence of ground glass opacity, small nodules merging together in the subpleural zones, consolidation, pulmonary interstitial fibrosis, pneumothorax were found in 28,16,18,17,5 cases, respectively in artificial stone?agglomerated quartz associated silicosis group, and 2, 4, 4, 4, 0 cases, respectively in the traditional classical silicosis group. The percentages of these above signs were higher in the artificial stone?agglomerated quartz associated silicosis group than the traditional classical silicosis group, and the differences were statistically significant(P<0.01). The artificial stone?agglomerated quartz associated silicosis group had 3 cases with mediastinal lymph node enlargement with calcification, while the traditional classical silicosis group had 12 cases. This sign showed a lower significantly incidence in the artificial stone?agglomerated quartz associated silicosis group than the traditional classical silicosis group(P<0.01). Conclusion The characteristic changes of CT imaging features in artificial stone?agglomerated quartz associated silicosis are small nodules with the background of ground glass opacity, the nodules merging together under subpleural zones, consolidation, mediastinal lymph node enlargement with less calcification and complicated with pulmonary interstitial fibrosis and pneumothorax.

Objective: To explore the CT imaging features of artificial stone-agglomerated quartz associated silicosis. Methods: A total of 37 cases confirmed with artificial stone-agglomerated quartz associated silicosis from December 2016 to August 2018 and 38 cases confirmed with traditional classical silicosis at the same period were retrospectively reviewed.The clinical characteristics (including gender, age and working age)and the imaging features (including the nodule features, ground glass opacity, merging features, consolidation, secondary changes, etc.) of the two groups were recorded. The variables including the imaging findings between the two groups were analyzed by Fisher exact test. Results: Of all the cases, there were bilateral diffuse small nodules which distributed with upper-zone predominance. Small nodules can merge together and form mass shadow. The complications such as lymphadenopathy, calcification, emphysema/pneumatocele, pulmonary interstitial fibrosis could also be found. Among the various imaging features, the presence of ground glass opacity, small nodules merging together in the subpleural zones, consolidation, pulmonary interstitial fibrosis, pneumothorax were found in 28,16,18,17,5 cases, respectively in artificial stone-agglomerated quartz associated silicosis group, and 2,4,4,4,0 cases, respectively in the traditional classical silicosis group. The percentages of these above signs were higher in the artificial stone-agglomerated quartz associated silicosis group than the traditional classical silicosis group, and the differences were statistically significant (P<0.01). The artificial stone-agglomerated quartz associated silicosis group had 3 cases with mediastinal lymph node enlargement with calcification, while the traditional classical silicosis group had 12 cases. This sign showed a lower significantly incidence in the artificial stone-agglomerated quartz associated silicosis group than the traditional classical silicosis group (P<0.01). Conclusion The characteristic changes of CT imaging features in artificial stone-agglomerated quartz associated silicosis are small nodules with the background of ground glass opacity, the nodules merging together under subpleural zones, consolidation, mediastinal lymph node enlargement with less calcification and complicated with pulmonary interstitial fibrosis and pneumothorax.