Objective　To explore the cause, diagnosis and treatment of retroperitoneal fibrosis.Methods　5 cases of retroperitoneal fibrosis were respectively treated by moving ureter into abdomen cavity, encapsulating with pediculate omenta and ilel ureter.Results　Following-up of 5 cases for 1 to 3 years, all cases had normal renal functions and hydronephrosis were much decreased.Conclusions　Intravenous urogenous(IVU),retrograde pyelography(RGP) and computed tomography (CT) are important methods to diagnose the disease. And the treatment method chosen depends on the range, location of ureterostenosis, and whether the ureter is open or not.

Objective: To search for the small molecule inhibitor with anti-tumor activity by fibroblast growth factor receptor 1 (FGFR1) as target. Methods: The analogue B6 of EF24 was obtained by reforming mono carbonyl curcumin analogues and applied to identifying the target with FGFR1 kinase activity assay. The effect of EF24 and its analogue B6 on the proliferation of HL7702 in normal human and four tumor cells, such as NCI-H460, SGC-7901, A549, and U251; With the concentration of 2.5, 5, and 10 μmol/L, B6 was used to investigate the phosphorylation inhibition of bFGF/FGFR downstream signal protein expression in NCI-H460 cells and Caspase-3 factor expression. Results: With the FGFR1 as target, B6 could inhibit the phosphorylation of FGFR1 in NCI-H460 cells, AKT, and ERK1/2; It also could inhibit the proliferation of cancer cells and promote cell apoptosis. Conclusion: The analogue B6 of EF24 is obtained from the leading compound EF24 with in vitro anti-tumor effect, which provides the basis of looking for the candidate anti-tumor drugs of FGFR1 inhibitor.

Ginger as a commonly used Chinese materia medica, but also edible, has been widely cultivated in China. Complex chemical components have been found more than 100 kinds, they are mainly sesquiterpenes and monoterpenes. Gingerol and zingiberol are as the active ingredients of ginger. In the literature of ginger, we found that most of them are on gingerol while less on zingiberol; More of them confused or mixed the two. In this paper the related literatures at home and abroad analyze the structure and pharmacological effects as well as the application of gingerol and zingiberol.

Polygonati Rhizoma industry as an important part of traditional Chinese medicine industry in China, There are a lot of problems in the resources, planting, processing, and each aspect in the market, which affect the Polygonati Rhizoma industry. It is the countermeasures for the corresponding problem that could ensure the industrialization, large scale, and internationalization of Polygonati Rhizoma industry. The corresponding problems are cataloged and the countermeasures which affect Polygonati Rhizoma industry are studied by accessing to a large number of related papers and investigating each Polygonati Rhizoma producing area. The optimal means to solve the problem faced in Polygonati Rhizoma industry is to plant Polygonati Rhizoma in a scale and comprehensive research and development of relative products of Polygonati Rhizoma, which is the way for the development of Polygonati Rhizoma industry in future.

Aerospace physiology is an important part of aerospace medicine.There are some problems existing in the current practice classes.Microlecture is a new kind of teaching methods.With its advantages, microlecture improved the teaching efficiency, and played a good role in the practice classes for undergraduate students, successfully solving part of the problems and promoting the teaching reform.The microlecture, as an auxiliary means, provides a new way for practice class of aerospace physiology.It`s suggested to be popularized in undergraduate teaching of aerospace medicine.

Objective: To explore comprehensive treatment for severe infection caused by ureteral calculus. Methods: The clinical data of 12 patients with severe infection caused by ureteral calculus in the Second People's Hospital of Lianyungang from January 2016 to December 2017 were reviewed.The patients cured by anti-infective therapy received one-stage surgical treatment.The patients with ineffective anti-infective therapy received one-stage cystoscopic retrograde double J tube or B ultrasound-guided percutaneous nephrostomy first, then ureteral calculus was treated. Results: Two patients were cured by empirical antimicrobial agents.One patient was successfully cured by extracorporeal shock wave lithotripsy (ESWL) and the other by retroperitoneoscopic ureterolithotomy.Ten patients were not responsive to empirical antimicrobial agents.Two patients refused treatment and requested discharge from the hospital.The other 8 patients received two-stage treatment.In the stage I, cystoscopic retrograde double J tube was accomplished in 3 patients, and 5 patients were treated successfully by percutaneous nephrostomy guided by B ultrasound.In the stage II, one patient with ureter stone-street was cured by lithagogue drugs, 2 patients were successfully cured by ESWL, one patient by holmium laser lithotripsy under ureteroscope, 2 patients by ureterolithotomy and 2 patients by percutaneous nephrolithotomy by endoscopy and holmium laser. Conclusion The therapy of retrograde double J tube at cystoscopy or percutaneous nephrostomy guided by B ultrasound combined with empirical antimicrobial agents in the satae I, combined with lithotripsy according to guidelines in the stage II in treating severe infection caused by ureteral calculus have more advantage such as simple, less injury, rapid control of infection, less complication and satisfactory effect.It is an ideal method.

Objective To evaluate the clinical and pathological characteristics and treatment of penile schwannoma.Methods One case of penile schwannoma was reported,and the relevant literature was reviewed to investigate the histogenesis,diagnosis and treatment of this disease.Related literature from PubMed and Wanfang databases to date(up to April 2017)with"penis" or"penile" combined with "schwannoma" or"neurilemmoma" as search terms was reviewed.Results One 40-year-old male presented in October 2015 with a tumor at the root of the dorsal penis for 1 year.Physical examination revealed a non-tender,easily movable without adhesion to the skin,1.2cm ×0.8cm nodule at the root of the dorsal penis,the overlying skin was smooth and intact.No evidence of neurofibromatosis was found.Hypoechoic well-defined nodule(1.7cm ×0.4cm)located between the superficial skin and corpus cavernosum was showed on ultrasound without blood flow signal.Simple excision of the tumor was performed under local anesthesia.Grossly,the tumor was a well-defined,white,soft 1.5cm ×1cm ×0.7cm nodule.Microscopically,the tumor was composed of Antoni A area with hypercellular and nuclear palisading.Immunohistochemical staining showed S-100(+++),SMA(-),Act(-).The pathological diagnosis was penile schwannoma.Postoperatively,the patient recovered well without erectile dysfunction.During a follow-up 18 months,the patient had no recurrence.By literature review,we found 14 cases in Chinese articles with one malignant case,while 33 cases in English articles with six malignant cases.The average age of onset was 39.2 years.Most of the tumors are benign and located in the dorsal side of the penis.Penile schwannoma can be diagnosed properly based on pathological examination,owing to the lack of typical clinical and imaging manifestation.The tumor resection was the treatment of choice for benign penile schwannoma without postoperative complications.Conclusion Penile schwannoma is extreme rarity,but can be diagnosed properly based on postoperative pathological examination,owing to the lack of typical clinical and imaging manifestation.S-100 is a useful marker for the diagnosis of schwannoma.The tumor resection is the treatment of choice for benign penile schwannoma without erectile dysfunction or recurrence ;for the malignant,the final diagnosis relies on postoperative pathological examination after the secondary operation with local recurrence.The tumor resection combined with radiotherapy and chemotherapy is reliable treatment,but the prognosis is poor.