OBJECTIVE To investigate the situation of hospital-acquired fungal infection of 75 cases with advaced lung cancer patients.METHODS The clinical information of deep fungal infection in 75 advanced lung cancer patients was investigated.The risk factors,the site and species were analyzed.RESULTS The lower respiratory tract and oral imfections accounted for 65.3% and 114.6% in 75 cases with deep fungal infections.Eighty-two stranins were isolated from various clinical specimens,in which Candida ailbicans and C.palasilosis accounted for 53.7% and 14.6%,respectively.CONCLUSIONS The rate of the deep fungal infection in advanced lung cancer patients is increasing.It is related to primary tumor,the amounts of white cells,invasive operation,age and use of antibiotics.