A total of 72 patients with first-episode mild-and-moderate depression took Qishen Fukang Capsules.The change of event-related potential P3 was determined before and after treatment for 6,12 and 24 weeks.And another 70 healthy controls received the same tests simultaneously.Compared with before treatment,HAMD scores after treatment were lower in the patient group [(29.1 ± 5.1) score vs.(10.4 ±4.1) score].P3 latencies were shorter and amplitudes became higher after treatment (P ＜0.01).And the difference of before and after treatment for 6 weeks was larger than the difference of 12 weeks and after treatment for 6 weeks (P ＜ 0.01).The curative effect is definite.And the clinical symptoms and brain evoked potential index have improved in patients with first-episode mild-and-moderate depression after medication.

OBJECTIVETo establish the normal MESH diagrams of Chinese in Beijing, and to build a computerized MESH analysis system for orthodontic practice.

METHODSTwenty-eight subjects with normal occlusion were selected in Beijing and their lateral cephalograms were taken at the age of thirteen and eighteen, respectively. Individual MESH diagrams were then established for each subject mainly according to Moorrees' method from the cephalograms orientated in estimated natural head position. Male and female normal MESH diagrams were created. A computerized MESH analysis system was also developed.

RESULTSThe normal MESH diagrams of Chinese in Beijing, thirteen and eighteen years old respective, were established. The computerized MESH analysis system was constructed and used in orthodontic patients.

CONCLUSIONSMESH analysis is a proportional analysis method. It can show the results directly, succinctly and holistically. It is also a favorable complement and amendment to the commonly used angle and linear X-ray analysis methods.

Adolescent ; Asian Continental Ancestry Group ; Cephalometry ; methods ; Dental Occlusion ; Female ; Humans ; Image Processing, Computer-Assisted ; methods ; Male ; Radiography ; Skull ; anatomy & histology ; diagnostic imaging

Animals ; Behavior, Animal ; drug effects ; Depressive Disorder ; drug therapy ; psychology ; Eleutherococcus ; Male ; Plant Extracts ; pharmacology ; Rats ; Rats, Sprague-Dawley ; Stress, Psychological

OBJECTIVETo analyze the morphological characters of Angle's Class III malocclusion patients and the relationship between characters and treatment options.

METHODSA total of 472 Class III patients were collected during 1997-2000. The standardized coordinates' values of the patients were obtained by Procrustes superimposition (PS). Cluster analysis was carried out to divide the patients into different subdivisions and the relationship between treatment options and subdivisions was analyzed.

RESULTS472 patients were divided into 14 subdivisions with special characters. The morphological templates were formed by computer. There were certain relationships between characters and treatment options.

CONCLUSIONThe mechanism of malocclusion of different Class III patients are not necessarily same. The typing has significance to choose the treatment method.

Female ; Humans ; Male ; Malocclusion ; Malocclusion, Angle Class III ; Orthodontic Appliances

OBJECTIVETo investigate the different changes after maxillary protraction between the cleft and non-cleft patients with anterior crossbite.

METHODSProspective controlled clinical trial was carried out. Eighteen patients (aged 9.6 +/- 1.2 years) with unilateral cleft lip and palate (UCLP) were chosen as the experimental group. Eighteen non-cleft patients (aged 9.8 +/- 1.4 years) with similar malocclusions were selected as control group. All the patients were before puberty according to the evaluation of the hand wrist radiograms. Hyrax appliance and reverse headgear were used in both experimental and control groups. Lateral cephalometric radiographs were taken before and after treatment. Computerized cephalometric analysis was carried out. Paired t tests or t test were performed using software package SAS 8.1.

RESULTSAfter treatment, the main changes in experimental group were: SNA +1.45 degrees , A-TFH +2.19 mm, SNB -2.18 degrees , ANB +3.64 degrees , MP/SN +2.78 degrees , LL-EP +0.88 mm in UCLP group. And in control group were: SNA +1.42 degrees , A-TFH +2.12 mm, SNB -1.32 degrees , ANB +2.68 degrees , MP/SN +1.47 degrees , LL-EP -1.37 mm.

CONCLUSIONSBefore puberty, maxillary protraction could accelerate maxillary forward growth in UCLP patients and the changes were similar to non-cleft patients. The occlusal relationship and soft tissue profile were improved significantly in both patients with or without cleft. The amount of mandibular posterior rotation in patients with UCLP was larger than in those with no cleft.

Cephalometry ; Child ; Cleft Lip ; surgery ; therapy ; Cleft Palate ; surgery ; therapy ; Female ; Humans ; Jaw Relation Record ; Male ; Malocclusion ; therapy ; Maxilla ; growth & development ; Osteogenesis, Distraction

Objective To investigate the characteristics and diagnostic value of 18F-fluorodeoxyglucose (FDG) PET/CT in patients with secondary malignant peripheral nerve lesions. Methods 18F-FDG PET/CT studies of 8 cases of secondary malignant peripheral nerve lesions confirmed by histopathology or follow-up were analyzed retrospectively. The maximum standardized uptake value ( SUVmax ) of infiltrating peripheral nerves and contralateral normal peripheral nerves was measured and compared with their morphological appearances on CT. Paired student t-test was performed by SPSS 10.0. Results Twelve secondary malignant peripheral nerve lesions with high 18F-FDG metabolism were found in 8 cases. On PET imaging,the lesions distributed along the neurovascular tissues or intervertebral foramina with appearances resembling those of fibre bundles,radices or nodes on PET but no density differences with the surrounding soft tissue or fat planes on CT. The SUVmax was 6.86 ± 3.87. The contralateral normal peripheral nerves showed no abnormal 18F-FDG uptake with a SUVmax of 1.10 ±0.46,which was significantly different from that of the secondary malignant peripheral nerve lesions (t = 9.231,P ＜ 0.001 ). Conclusion 18 F-FDG PET/CT may be useful in locating the secondary malignant peripheral nerve lesions and in assessing its regional infiltration.

OBJECTIVETo observe the clinical combination effect of Jinlong Capsule (JLC) and transcatheter arterial chemoembolization (TACE) on the patients with primary hepatic carcinoma (PHC) and JLC' s influence on serum osteopontin (OPN) expression and elucidate the correlation between the serum OPN level and curative effect of JLC and TACE.

METHODSA total of 98 patients with PHC were observed in a randomized controlled trial (RCT). They were assigned to the Chinese medicine (CM) group (53 patients who were treated with TACE and JLC) and the intervention group (45 patients who were treated with TACE only). The serum OPN levels were measured before and after treatment by quantitative sandwich enzyme-linked immunosorbent assay (ELISA). Forty healthy people were assigned to the control group. The clinical efficacy was observed and Karnofsky score (KPS) was graded.

RESULTSThe clinical efficacy of the CM group (60.38%) was better than that of the intervention group (40.00 %), and the KPS (84.35+/-12.19) was higher than the intervention group (69.86+/- 11.58) (P<0.05). The serum OPN levels before and after treatment in the patients with PHC were significantly elevated compared with those in the control group (P<0.01). After treatment, the OPN levels in CM group (117.69 <+/-78.50) were significantly lower compared with those in intervention group (151.09+/-83.90, P<0.05). The OPN levels of responders were remarkably lowered than the non-responders after treatment, and the level of OPN in the CM group was lower than the intervention group (P<0.05).

CONCLUSIONSThe short-term clinical efficacy and the quality of life of patients with PHC can be improved by combining JLC with TACE. The serum OPN levels in PHC patients can reflect the curative effect of treatment and the prognosis of the disease.

Adult ; Aged ; Antineoplastic Agents, Phytogenic ; administration & dosage ; Capsules ; Carcinoma, Hepatocellular ; blood ; metabolism ; therapy ; Catheterization, Peripheral ; methods ; Chemoembolization, Therapeutic ; methods ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Liver ; blood supply ; Liver Neoplasms ; blood ; metabolism ; therapy ; Male ; Middle Aged ; Osteopontin ; analysis ; blood ; metabolism ; Time Factors ; Treatment Outcome

OBJECTIVETo investigate the changes of available spaces of posterior arch segments in mandibular dentition from 13 to 18 years of age, which would provide information for space analysis of whole dental arch in adolescents.

METHODSTwenty-six adolescents (12 males, 14 females) with normal occlusion were selected. All of the subjects had lateral cephalograms taken at the same time each year for 6 years. Longitudinal cephalometry and statistic analysis were conducted for all subjects.

RESULTSSignificant differences of available space were found between males and females. The growth of available space from 13 to 18 years of age was 5.12 mm in females and 5.79 mm in males. The completion of mandibular remodeling in males lagged behind females for about 1 year. No significant increase was found in girls beyond 16 years and in boys beyond 17 years. There was a 1.22 mm increase on each side per year in females until 16 years and a 1.45 mm increase in males until 17 years. The increase of available space was made partly by resorption of bone from the anterior border of the ramus and partly by mesial movement of the first molar. The mesial movement of dental arch was probably stimulated by the eruption of the third molars.

CONCLUSIONSThe prediction of available space should be based on age and sex.

Adolescent ; Age Factors ; Cephalometry ; Dental Arch ; growth & development ; Female ; Humans ; Longitudinal Studies ; Male ; Mandible ; growth & development ; Molar, Third ; growth & development ; Orthodontics, Corrective ; Sex Factors ; Tooth Eruption ; Tooth Migration

Objective To construct RhoA siRNA plasmid expression vector.Methods According to the computer aided design,RhoA-specific siRNA gene was synthesized and cloned into the RNAi-Ready Pgenesil-1 Vector.The constructed RhoA-RNAi plasmid were transfected into human HEPG2 cell.Western blot was used to detect the effect of RhoA-RNAi plasmid.Results The recombinant was cloned and the se- quence was obtained.RhoA-RNAi plasmid can down-regulate the expression of RhoA in human hepatocel- lular carcinoma cell line HEPG2.Conclusion Successfully cloning the recombinant makes it possible for searching new mechanism of RhoA in hepatocellular carcinoma.

Objective To evaluate the craniofacial and occlusional changes of Class Ⅱ patients treated with Tip-Edge Plus technique.Methods Twelve Class Ⅱ patients(7 girls and 5 boys,mean age 14.3 years)with bimaxillary or maxillary protrusion were selected.All the patients were four first premolar extraction cases and treated with Tip-Edge Plus technique.Cephalometric analysis Was performed to evaluate the changes before and after treatment.Results After treatment,the profile Was greally improved.UL-E,LL-E were decreased significantly(P<0.01)and incisors were retracted(P<0.05).Upper molars noved forward slightly(P>0.05).Conclusions The anchorage control in Tip-Edge Plus technique was effective without extraoral force,palatal arch and implants.Under very light force,the crown of anterior teeth tipped distally and lingually quickly.In the final stage,it was possible to achieve both desired root uprighting and crown torque.