Objective To study the effect of edaravone on serum IL-6、TNF-α and neurologic functional in acute cerebral hemorrhage,discuss the protective mechanism of Edaravone on cerebral hemorrhage.Methods 80 casesof cerebral hemorrhage in 72h were randomly divided into treatment group(40 cases)and control group(40 cases),and the control group was given routine treatment,and the treatment group was administered with edaravone,30mg/d,for 14 days on the based treatment of the control group.The serum IL-6 and TNF-αwere detcted by ELISA before therapy and after treatment for 14 days.Neurological function deficit scores were utilized for assessment before given treatment.On the 21 th day after treatment,the patients were assessed again,and the efficacy was recorded.Results After 14 days treatment.the mean scale of NIHSS,the serum levels of IL-6 and TNF-α in treatment group were more obviously decreased than that in control group(all P＜0.05).Conclusion Edaravone could obviously alleviate inflammatory reaction on acute cerebral hemorrhage,which could effectively remove the generous free radicals and reduce the brain edema after intracerebral hemorrhage.So it could protect the tissue of brain.

Objective To investigate the clinical characteristics and related factors of metabolic disorder in acute cerebrevascular disease (ACVD) and to provide clinical basis for intervention of ACVD.Methods The clinical data of 202 healthy individuals (control group) and 621 cases of ACVD (341patients with cerebral infarction and 280 patients with cerebral hemorrhage) was analysed retrospectively.Based on the level of blood pressure,blood glucose and blood fat, 621 cases of ACVD were divided into me tabolism syndrome( MS ) group (hypertension + hyperglycemia + hyperlipidemia),two kinds of risk fatorsgroup (hypertension + hyperglycemia or hypertension + hyperlipidemia or hyperglycemia + hyperlipidemia),one kind of risk factor group (hypertension or hyperglycemia or hyperlipidemia) and no risk fastor group.Results Of the patients with cerebral infarction and cerebral hemorrhage 320 eases(93.8%) and 259 cases (92.5%) had hypertention,163 cases (47.8%) and 101 cases (36.1%) had hyperglycemia, 115 cases (33.7%) and 141 cases (50.4%) had hyperlipidemia, respectively. The blood pressure in one kind of risk factor group, two kinds of risk factors group and MS group was significantly higher than those in control group and no risk factor group,the body mass index (BMI), fasting plasma glucose (FPG),total cholesterol(TG)and low density lipoprotein cholesterol (LDL-C) in two kinds of risk factors group were higher than those in control group and no risk factor group (P <0.05). The age,BMI,blood pressure,FPG,TC,TG,high density lipoprotein cholesterol(HDL-C) and LDL-C had obvious correlation with ACVD. Conclusion ACVD is often combined with various kinds of metabolic disorders risk factors, suggesting that an effective control of metabolic disorders is benefit to intervention of ACVD.