Objective To study the clinical application of a self-made needle-shaped ureteroscopic electrotome in the treatment of ureteral stricture. Methods Sixty-seven patients with ureteral stricture (24 cases of stricture after ureterlithotomy, 39 cases of ureteral polyp and 4 cases of congenital stricture) were operated on by using self-made needle-shaped electrotome under ureteroscope. Results The operating time was 10~30 min and the intraoperative blood loss was 5~20 ml. Follow-up for 3 months showed effective results in 53 cases (79 1%), improved in 10 cases (14 9%) and unresponsive in 4 (6 0%). No severe complications emerged. Conclusions Application of self-made needle-shaped ureteroscopic electrotome in the management of ureteral stricture gives simple performance.

Objective To study therapeutic effects of ureteroscopic treatment for ureteral stones after failed extracorporeal shock wave lithotripsy (ESWL). Methods A total of 23 patients with ureteral stones received ureteroscopic treatment after the ESWL had failed. By using pneumatic lithotripter and self-made needle-shaped electrotome, stones were fragmented and removed, and polyps were resected. Results Two patients with stones fragmented but surrounded by granuloma tissue received a polyp resection and stone extraction.Pneumatic ballistic lithotripsy and stone removal was conducted in 16 patients with stones partly fragmented.In 4 patients with stones adherent to the ureteral wall and polyps,the polyps were removed by using self-made needle-shaped electrotome and the stones were fragmented and extracted.And in 1 patient with stones embedded beneath the ureteral mucous membrane, which was difficult to be expelled,the mucous membrane covering the stones was opened by using the needle-shaped electrotome and the stones were fragmeathed and extracted.The procedure duration was 30~55 min(mean,42 min).Re-examination 6 months postoperatively found no residual stones. Conclusions After the ESWL had failed, patients with ureteral stones can be treated ureteroscopically by using pneumatic lithotripsy and self-made needle-shaped electrotome.

Objective To investigate the effect of tuftsin and its inhibitor on pancreas microcirculation in acute pancreatitis(AP). Methods Sprague Dawley (SD) rats were randomly divided into five groups. Murine AP model was produced by retrograde injection of 4% sodium taurocholate into pancreatic duct, tuftsin or its inhibitor was injected at a dosage of 75 ?g/kg. At the time of 0,3, 6, 12 h, pancreas was harvested for pathology of microthrombus. esults Microthrombus in control group was not different with that in tuftsin group; At the time of 3、6 and 12 h microthrombus in other 3 groups significantly increased than control group and tuftsin group; With time, microthrombus in AP group、AP+ tuftsin group and AP+inhibitor group increased steadily and statistically significant; Tuftsin inhibitor significantly decreased microthrombus at the time of 6、12 h.Conclusions In acute pancreatitis tuftsin deteriorated pancreas microcirculation, which could be partially reversed by the administration of tuftsin inhibitor.

Objective To assess the clinical relevance of polymorphisms at position-251 in the promoter region of IL-8 gene and the incidence of sepsis in patients with severe trauma.Methods A total of 296 patients with severe trauma were included in the prospective cohort study.Incidence of sepsis was decided on the basis of the clinical manifestations and blood culture results.Muhiple organ dysfunction score (MODS) was performed using Marshall' s standard.IL-8/-251 gene polymorphisms were genotyped using restriction fragment length polymorphism polymerase chain reaction (PCR-RFLP).IL-8 plasma level was determined using ELISA method.Results Genotype frequency at IL-8/-251 locus in trauma patients was in accord with Hardy-Weinberg equilibrium (P ＞ 0.05).Sepsis incidence in trauma patients with TT,TA,and AA genotypes at IL-8/-251 locus was 58.1％,49.6％,and 25.0％ respectively.Multiple regression analysis showed inverse correlation between sepsis incidence and quantity of A alleles [OR =0.637,95％ CI (0.421,0.963),P ＜ 0.05].Carriers of AA genotype presented lower MODS score than those of other two genotypes (P ＜ 0.05).IL-8 plasma level presented significant difference among carriers of the three genotypes (P ＜ 0.01) and A alleles were associated with the down-regulation of IL-8 (P ＜ 0.01).Conclusion IL-8/-251T/A polymorphisms are implicated in the development of posttraumatic sepsis and AA genotype is protective against posttraumatic sepsis.