Objective To investigate researches on magnet hospital and nursing management from January 1,2010 to December 31,2014 in PubMed database and provide reference information for the majority of professionals in deep research.Methods Bibliographies from research literature of magnet hospital and nursing management from January 1,2010 to December 31,2014 in PubMed database were downloaded.The publication years,journals,countries of publication,the high yielding first authors and the high frequency of main subject were counted by Bicomb 2.0 software.The affiliations were analyzed artificially.main subject appeared no less than two times were intercepted as high frequency ones and the high frequency main subject co-occurrence matrix were formed.SPSS20.0 statistical software were applied for clustering analysis with matrix,then to get the topic hotspots.Results A total of 62 literatures were screened out.The data of research trend,journals,research degree of countries were acquired.The number of high frequency main subject were 18 and among which 4 research hotspots were clustered,respectively workplace environment and job satisfaction,nursing education,nursing quality administration,creation and leadership.Conclusions Researches on magnet hospital and nursing management from January 1,2010 to December 31,2014 in PubMed database are mainly in terms of workplace environment and job satisfaction,nursing education,nursing quality administration,creation and leadership.They are the foundation of the current research situation and trend of magnet hospital nursing management,and can improve management efficiency and provide reference for scientific research topic selection project.

Obejective To analyze the related papers on nursing competency in China from 2004 to2014,and to learn the current status and developing trends of nursing competency,so as to provide reference for further research and development of nursing competency.Methods All literature related to nursing competency from 2004 to 2014 were searched in the China National Knowledge Infrastructure(CNKI),VIP Database for Chinese Technical Periodicals (VIP),and Wanfang database.Bibliometric analysis methods were used to analyze the distribution time,area,journal distribution and research categories by using Microsoft Excel.Results Totally 199 articles related to nursing competency were collected and the number of publications increased in recent years.About 78.89％ (157/199) papers were published in the statistical source journal and 34.17％ (68/199) papers were focused on survey research about nursing competency.Conclusions Nursing competency have been paid more attention to,but the quality of the literature still need to be improved.

Objective To investigate the charge nurses' leadership style perceived by nurses and nurse's self-efficacy,and then analyze the relationship between them.Methods Totally 368 staff nurses from 3A hospitals in Sichuan were investigated with questionnaires.The results underwent analysis.Results The score of charge nurses' transformational leadership style was 58.06±12.10,from high to low in turn was intellectual stimulation (3.10±0.69),inspirational motivation (2.92±0.73),idealized influence (2.88±0.67) and individualized consideration (2.71±0.74).The score of charge nurses' transactional leadership style was 35.77±8.58,from high to low in turn was contingency reward (3.11±0.71),passive exemplary management (3.09±0.75) and active exemplary management (2.75±0.90).The score of nurses' self-efficacy was 83.51±11.62.The transformational leadership style had positively predictive impact on nurses' selfefficacy.Conclusions Nursing managers should apply transformational leadership to improve nurses selfefficacy,promote the physical and mental health of nurses and the long-term development of hospital.

The purpose of this review is to explain the function of LL-37 in the pathogenesis of chronic sinusitis. LL-37 is the only human cathelicidin identified so far. LL-37 is an integral part of the innate immune,the role of which in chronic sinusitis is attracting more and more s attention.
Cathelicidins ; metabolism ; Chronic Disease ; Humans ; Sinusitis ; immunology ; metabolism ; pathology

Since the transcranial magnetic stimulation (TMS) is a non-invasive technique to interfere neu-ral activity of brain, the combination of TMS and other neuron-imaging techniques has been widely used, espe-cially in cognitive research. Electroencephalogram (EEG) occupies a special position in this field due to its higher time resolution and lower experimental cost. The present paper reviews the application of TMS-EEG combined technique from the aspects of the main research topics, simultaneous recording, artifacts elimination, data pro-cessing and so on. Current problems and possible solution related to this technique are also discussed in the pa-per. With those new related solutions being put forward, more achievements will be obtained in the research area of TMS-EEG combined technique.

Objective To investigate the nurses′tasks in community hospitals in southwest China, so as to provide references for building nursing profession advanced examination system matching with the clinical requirements of community. Methods Different Professional Titles Nurses′ Tasks Questionnaire developed by the Ministry of Health was used to investigate 201 nurses in 10 community hospitals that were randomly selected in southwest China. Results Nurse professional title with primary title mainly accounted for 59.20% (119/201),and the nurses who had received secondary and college degree accounted for 43.28%(87/201), 38.81%(78/201). 120 items of nursing tasks were divided into 8 dimensions, the highest of implementation frequency score was the dimension related with drug treatment which scored 3.05±1.18, while the lowest was related with meeting the patients′basic needs which scored 1.40 ± 1.05; the highest of tasks′ importance assess score was the task dimension related with drug treatment which scored 3.36 ± 0.56, while the lowest was the dimension of communications which scored 2.74 ± 0.81. The correlation analysis of execution frequency and importance assess of each dimension showed a significant positive correlation (r=0.161-0.397,P<0.05), except the dimension related with drug treatment(r=0.128,P>0.05). Score difference of tasks’execution frequency and importance evaluation for different Professional titles nurses had no statistical significance (P>0.05). Conclusions The reform of the nurses′career advanced examination should be combined with development status and nurses′tasks in community, in addition, both raising the nurses′ comprehensive quality and improving job responsibilities and functions division of community is the basis of the reform.

0 05),while in the second group there was significant difference( P

OBJECTIVE:To discuss the significance of pharmacoeconomics applying in essential medicine system(EMS) and the duty of licensed pharmacist. METHODS:The relationship between theory of pharmacoeconomics and EMS was analyzed. Moreover,the theory of pharmacoeconomics served as technique to apply in EMS. RESULTS&CONCLUSION:Pharmacoeconomics is the theoretical basis of establishment of EMS so that it is important significance to guide the choice of essential medicines,establishment and improvement the production,supplication and using system of essential medicines. Medical staff should carry out the monitory and evaluation of national essential medicine system(NEMS) in practice and implement NEMS consciously.

AIM To study the effects of recombinant human IL 1 receptor antagonist (IL 1ra) on isolated airway smooth muscle tissue. METHODS Changes of isolated organ's tension were monitored with force displacement transducer and MedLab recording system. RESULTS ①IL 1ra haddirect relaxant effect in normal and ovalbumin sensitized pulmonary as well as tracheal smooth muscle. The mean EC 50 values were 1 29?10 -8 mol?L -1 and 8 06?10 -8 mol?L -1 in normal pulmonary and tracheal smooth muscle, but the mean EC 50 values were 2 61?10 -7 mol?L -1 and 5 88?10 -7 mol?L -1 in ovalbumin sensitized pulmonary and tracheal smooth muscle. Therefore the relaxation responses of sensitized airway smooth muscle to IL 1ra were lower than those of normal pulmonary and tracheal smooth muscle.②IL 1ra(10 -9 ～10 -5 mol?L -1 ) concentration dependently inhibit contraction responses to histamine(10 -3 mol?L -1 ) in normal pulmonary and tracheal smooth muscle, compared with administrating solvent PBS group ( P

OBJECTIVE:To study the tumor targeting of RGD-PEG-liposomes METHODS:RGD-PEG-liposome was prepared by reverse phase evaporation method and combination with GRGDS peptide Tumor targeting was studied in Colon 26 tumor bearing mice RESULTS:RGD-PEG-liposomes showed good tumor targeting effect on colon 26 tumor bearing mice CONCLUSION:RGD containing polypeptide conjugated,long-cyclic lipsome may become a new-type,receptor-mediated targeting agent