OBJECTIVE:To investigate the perioperative use of antibiotics in patients with acute appendicitis.METHODS:The perioperative use of antibiotics in 330 surgery patients with acute appendicitis from Jan.2003 to July 2006 in a 3-A grade hospital was analyzed retrospectively in respect of drug variety,DDDs,drug combination,administration etc.RESULTS:A total of 6 groups(25 kinds)of antibiotics were used in all the 330 cases,of whom,8(2.42%)used single kind,259(78.48%)used two kinds concomitantly,and 63(19.09%)used 3 kinds concomitantly;43(13.03%)used antibiotics rationally,and 287(86.97%)used antibiotics irrationally;61.21% were not given antibiotics before operation.The average medication time for patients without preoperative use of antibiotics was 8.68 d vs.7.53 d for those with preoperative use of antibiotics,showing significant differences between the two groups(P

OBJECTIVE:To probe into the characteristics of adverse drug reactions (ADR) occurred in our hospital. METHODS: 340 ADR cases collected from Jan. 2004 to Dec. 2008 in our hospital were analyzed retrospectively. RESULTS: Of the total 340 ADR cases,80 (23.53%) were collected from pharmacy department;63.83% occurred in patients aged from 21 to 60 years,with females showing higher proportion than males;83.24% were induced intravenously,48.08% were induced by anti-infective drugs,of which,cephalosprins and quinolones took the lead. 38.05% of the ADR manifested as lesion of skin and its appendants. CONCLUSION: ADR monitoring should be strengthened in clinic;furthermore,the quality of ADR reporting should be improved and the use of drugs should be rationally in a standard way so as to lessen or avoid the occurrence of ADR.

Most previous researches on nuclear factor κB (NFκB) are limited to immune cells. Recently, however, researches on NFKB in muscle cells attract more attention. Target genes of NFκB encodes proteins with different functions, accordingly NFκB can not only induce inflammation deterioration, protein degradation and tissue injury but also promote cell growth and maintenance. But the inhibitation effect of NFκB inhibitors is not related with its antioxidant capacity. Exercise can activate NFκB during which process NFκB may act as an inducer of cell growth and development which is different from its role under pathological situation. This article sums up and analyzes the effect of NFκB on cell growth, the changing trend and effect of NFκB in skeletal muscle under exercise, providing data for the researches on muscle rehabilitation and motion fitness change.

Lactate shuttle is the process of lactic migration thmugh membrane with monocarboxylate transporters(MCTs)and anti-exchange ion,including intracellular and extracellular modes.The effect of MCTs specific distribution on lactate shuffle and the structure and mechanism of anti-exchange ion transporter is unclear.Any factor which infiuences lactate production.oxidation,MCTs expression and blood circulation can regulate lactate shuttle.That lactate induces ASIC channel to open may affect the Sensory nerve bnnging about pain.Various lactate shuttles may induce vanous kinds of pain,Ageing,but not inactivity,decrease lactate accumulation and shuttle leading to the decreased fatigability of skeletal muscle.The regulation mechanism and energy supply extend of lactate shuttle need to be investigated.Lactate shuttle may be one important factor to regulate the biological effect of lactate such as vanous muscle pain,fatigability and etc.Lactate shuffle effect on body function regulation is a noticeable problem in muscle rehabilitation and excise-inducad adaption fields.

OBJECTIVE: To study the photostability of the levofloxacin hydrochloride injection. METHODS: The content of levofloxacin hydrochloride was determined and its UV spectra changes were observed after being lighted by three different light sources-the UV light, the sunlight and the natural light for different periods of time. Whether there is any decomposed product or not was determined by TLC. RESULTS: There were decompositions of levofloxacin hydrochloride injection subjected to illumination from three light resources, with that under the sunlight decomposed faster; Rf value under TLC of the decomposed product was found to be 0.72. CONCLUSION: Levofloxacin hydrochloride injection should be kept away from UV light, the sunlight and the natural light.

Objective To evaluate the early diagnosis value of procalcitonin (PCT) in severe brain damage combined with pul‐monary infection .Methods The brain injury patients in the hospital from January to October 2014 were enrolled in the study and divided into infectious group whose infection had occurred within 5 days after admitting to hospital and non‐infectious group who had not suffered from infection .The blood samples of the patients were collected within 2 h and 3 days after admitting to hospital and detected for PCT concentration .The Early diagnosis value of PCT in brain damage combined with pulmonary infection was e‐valuated and compared with white blood cells (WBC) ,neutrophile granulocyte(N)and hypersensitive C‐reactive protein(hs‐CRP) . Results The incidence of pulmonary infection within 5 days of severe brain injury was 22 .9% (41/179) .There were statistically differences of PCT ,WBC ,N and hs‐CRP between infectious group and non‐infectious group(P< 0 .05) .The areas under curve (AUC) of PCT ,WBC ,N and hs‐CRP were 0 .83 ,0 .80 ,0 .78 and 0 .82 respectively .The combination of PCT+WBC+ hs‐CRP had the highest diagnostic value since its AUC was 0 .87 .PCT had a satisfied diagnostic veracity since it had good sensitivity ,specificity and positive predictive value in the diagnosis of brain damage combined with pulmonary infection .Conclusion PCT could be an ear‐ly diagnosis indicator in severe brain damage combined with pulmonary infection ,and the diagnostic veracity is higher when com‐bined with WBC and hs‐CRP .An antimicrobial treatment is recommended when PCT concentration of brain damage patient rises , especially when combined with WBC and hs‐CRP concentration elevating .