Objective:To observe the clinical effect and adverse reactions of salmeterol fluticasone propionate in the treatment of cough after infection to provide basis for the clinical treatment. Methods:Totally 324 patients with cough after infection were selected randomly divided into the control group and the treatment group with 162 cases in each. The control group was given routine therapy and the treatment group was treated with salmeterol fluticasone propionateon additionally. Daytime and night cough symptom scores were evaluated before and after the treatment,symptom disappearance time was recorded,and cough severity was assessed using visual analogue scale. The adverse reactions were observed as well. Results:The daytime and night cough symptom scores and visual analog score of the treatment group after the treatment were all lower than those of the control group after the treatment with statistically significant differences(P < 0. 05). The symptom disappearance time of the treatment group was shorter than that of the control group with statistically significant difference(P < 0. 05). The incidence of adverse reactions in the two groups showed no statistically significant difference(P > 0. 05). Conclusion:Salmeterol fluticasone propionate shows better clinical curative effect in the treatment of cough after infection,which can significantly improve the clinical symptoms of patients and shorten the time of symptoms improvement with high security and is worthy of clinical popularization and application.

Objective To explore the influence of Montelukast in the treatment of patients with bronchial asthma on the immune response,and to provide the basis for clinical treatment.Methods 104 patients with bronchial asthma were selected.They were randomly divided into the treatment group and the control group by the random number table method,with 52 cases in each group.The control group patients were given conventional treatment,and the treatment group were treated with Montelukast on the basis of the control group.Daytime symptom and night symptom of the two groups before and after treatment were assessed,and airway reactivity by the early respiratory resistance (Rrsc)and response threshold (Dmin)were evaluated.And the change of T lymphocyte subsets before and after the treatment were detected.Results The day symptom scores,night symptom scores and Rrsc of the treatment group after treatment were respectively (0.49 ±0.12)points,(0.66 ±0.20)points and (2.19 ±0.38)cmH2 O,which were lower than those of the control group after treatment(t =7.90,8.13,8.24,all P <0.05).The data of the two groups after treatment were lower than those before treatment,the differences were statistically significant (t =9.38,8.66, 9.17,9.41,8.90,9.24,all P <0.05).Dmin of the treatment group after treatment was (8.29 ±0.44)U,which was higher than that of the control group after treatment,the data of the two groups after treatment were higher than those before the treatment,the differences were statistically significant(t =7.41,8.23,all P <0.05).CD +4 and CD +4 /CD +8 of the treatment group after treatment were (43.03 ±5.02)% and(1.79 ±0.34),respectively,which were higher than those of the control group after treatment (t =9.81,10.04,all P <0.05 ).The data of the two groups after treatment were higher than those before the treatment,the differences were statistically significantly different (t =10.62,10.33,10.93,10.62,all P <0.05).CD +8 of the treatment group after treatment was (23.38 ±3.88)%, which was lower than that of the control group after treatment(t =9.93,P <0.05),the data of the two groups after treatment were lower than those before treatment,the differences were statistically significant (t =9.16,9.29,all P <0.05 ).Conclusion Montelukast treatment of bronchial asthma can significantly improve symptoms and immune function of patients,it is worthy of clinical popularization and application.

Objective To evaluate the clinical significance of the changes of microalbunminuria(MAU) levels in mechanical ventilated patients with severe pneumonia. Methods According to the ratio between the microalbunminuria and the urine creatinine (MAU/CR) (ACR), setting 25mg/mmol as the threshold, 78 mechanical ventilated patients with severe pneumonia were divided into two groups :ACR increasing group and ACR Non-increasing group,then the clinical significance of changes of MAU levels in 72 hours on prognosis of these patients was observed. Results MAU increased in 64 cases(82. 1%) ,of which 46 cases in ACR increasing group and 18 cases in ACR non-increasing group. There showed statistically significant differences on APACHE Ⅱ score, CPIS score,PCT、the success of getting out of mechanical ventilation and the mortality between two groups, (t = 3.50、2. 19 、x~2 = 3. 95、6. 70、5.38 ,P = 0.01,0.03,0.04,0.01,0.02, all P ＜ 0.05). Conclusion Changes of MAU levels have the clinical significance on prognosis of the mechanical ventilated patients with severe pneumonia.

There are many noise signals in original laser induced breakdown spectroscopy (LIBS) spectra.To explore the effect of spectral pretreatment on LIBS information by different filter methods, the LIBS spectra of Pb-polluted cabbage in wavelength range of 400.45-410.98 nm was investigated and preprocessed by adjacent averaging, Savitzky-Golay (S-G) and fast Fourier transformation (FFT).Then partial least square (PLS) model was established for evaluating the spectral treatment effect.The result showed that the root mean square error of prediction (RMSEP) and average relative error of S-G method were 0.26 and 3.7%, suggesting a superior smoothing effect than other methods.Experimental results indicated that an appropriate filtering method could help to improve the spectral quality and raise the precision of model checkout.

Porcine reproductive and respiratory syndrome is caused by the PRRS virus(PRRSV), which has six structural proteins(GP2, GP3, GP4, GP5, M and N). GP5 and N protein are important targets for serological detection by enzyme-linked immunosorbent assay(ELISA)and other methods. Toward this goal, we developed an indirect ELISA with recombinant GP5 antigens and this method was validated by comparison to the LSI PRRSV-Ab ELISA kit. The results indicated that the optimal concentration of coated recombinant antigen was 0.2 μg/well for a serum dilution of 1:40. The rate of agreement with the LSI PRRSV-Ab kit was 88.7%(266/300). These results support the potential use of recombinant GP5 as an antigen for indirect ELISA to detect PRRSV antibodies in pigs.

Objective:To analyze the health development plans of the provinces in China during the " 14th Five-Year Plan" , and explore the key tasks, similarities and differences of health informatization construction in each province.Methods:Using the website of local people′s government and the official website of the provincial Health Commission, 27 copies of health development plans of various provinces during the " 14th Five-Year Plan" period were retrieved and collected from February 16 to June 5, 2022. The relevant statements of health information in the plan were extracted, content analysis was used to reveal the structural characteristics of the policy in the form of word frequency statistics, and discourse analysis was used to study the policy content.Results:The health information policies of 27 provinces during the " 14th Five-Year Plan" period could be summarized as 10 major themes, such as accelerating the construction of hierarchical diagnosis and treatment system, promoting the high-quality development of public hospitals, and deepening the reform of medical security system. The health information policy in the eastern, central and western regions was relatively clear, and there were certain differences in the construction points according to their own characteristics.Conclusions:During the " 14th Five-Year Plan" period, the policies of each province around the field of health information are well defined, and the core structure and content are similar. The distribution of key points in the eastern region is relatively balanced; the construction of health information in the central region is more prioritized and prominent; the construction of health information in the western region is focused on complementing the weak links and weaknesses.