The changes of plasma ?-endorphin (?-HEP-ir) were studied by radioimmunoassay in 40 cases of definite myocardial ischemia and 35 of suspected myocardial ischemia before and after exercise test. The results indicated that the levels of ?-HEP-ir in patients with silent myocardial ischemia were higher and in those with angina pectoris were lower than the controls (P

With the development of image technology,functional imaging was gradually applied to contouring the gross target volume,which generated the concept of biological target volume and biological intensity-modulated radiation therapy.In this review,we introduced our work and the current status of ~(18)F-fluorodeoxyglucose imaging,amino acids imaging,nucleic acid imaging,hypoxic imaging,gene imaging and molecular imaging.The future of functional imaging and it application in biological intensity-modulated radiation therapy were discussed in prospect.

3′-deoxy-3′-18F-fluorothymidine has been described recently as a new positron emission tomography (PET) tracer for imaging tumor cell proliferation. In recent years, more and more clinical research demonstrate that 18F-FLT can image tumor cell proliferation during treatment, and can reflect accelerated reproliferation earlier. it can define tumor subvolumes with high proliferative activity preceding volumetric tumor response, and can predict relapse and prognosis according to the changing status during the treatment.

Objective To explore the value of combined determination of serum hepatic fibrosis index for evaluation on the degree of liver fibrosis in patients with chronic hepatitis B(HBV).Methods 275 patients with HBV were selected as chronic hepatitis group,which were divided into the mild chronic hepatitis group(75 cases),chronic moderate hepatitis group (72 cases),chronic severe hepatitis group (65 cases),liver cirrhosis group (63 cases) according to the severity of disease.In addition,50 healthy population were selected as the healthy control group.The four liver fibrosis indicators included serum hyaluronic acid(HA),laminin (LN),collagen type Ⅲ (PC Ⅲ),type IV collagen(IV-C) were determined by chemiluminescence immunoassay and compared among the groups,and the diagnostic results of combined different indicators were compared.Results The indexes of HA,PC Ⅲ,IV-C,LN were significantly higher than those of the healthy control group (t =2.567,2.687,2.811,2.741,all P ＜ 0.01).The hepatic fibrosis indexes were increased by with the severity and duration increased gradually (t =2.665,2.787,2.755,2.811,all P ＜ 0.01).The concentration-time curves area (AUC) of PC Ⅲ,Ⅳ-C,LN,HA were 0.680,0.825,0.716,0.826,respectively.Diagnosis value of three combination indicators in HA + PC Ⅲl + Ⅳ-C was highest.Conclusion The chemiluminescence dynamic detection of four liver fibrosis indicators is a good non-invasive detection method for guiding clinical diagnosis on the degree of liver fibrosis.

Objective To explore the clinical efficacy of tiotropium and salmeterol xinafoate and fluticasone propionate powder for inhalation combined with noninvasive ventilator in the treatment of respiratory failure, and to provide reference for clinical treatment.Methods 72 patients with respiratory failure were randomly divided into treatment group (n=36) and control group (n=36).The patients were randomly divided into treatment group and control group.Patients in the control group were treated with conventional noninvasive ventilators and treatment group were treated with tiotropium and salmeterol xinafoate and fluticasone propionate powder for inhalation on the basis of control group.Then compare the exercise tolerance, arterial carbon dioxide partial pressure, heart rate, pH, respiratory rate, blood oxygen pressure between two groups.Results After the treatment, condition of the patients in the two groups have different degrees of improvement.The final results showed that the average hospital stay was significantly reduced, respiratory frequency was(28 ±5) times/min in treatment group, heart rate was(98 ±16) times per minute, PaO2 also increased to(72 ±3) mmHg, PaCO2 was(57 ±17) mmHg, pH value increased to (7.42 ±0.03), compared with the control group, with statistically significant difference (P<0.05).Conclusion In patients with clinical implementation of tiotropium and seretide combined with non-invasive ventilator treatment of respiratory failure, can significantly improve the patient's condition, so that patients with respiratory function was significantly improved, so that the indicators of patients tend to normal.Its can effectively reduce PaCO2 , increased PaO2 and speed up its cure rate.

Objective To introduce improved techniques for one-stage operation of penile lengthening and thickening. Methods 8 cases were operated by this kind of procedure which comprised bilateral longitudinal incision of the corpora cavernosa and enlargement of the tunica albuginea using sapheneous grafts. Results All the cases gained satisfactory results without serious complications such as infection, fistula, and hemorrhage. All the cases who have married resumed regular and satisfactory sexual activities after one month without any functional limitation . The penile corpus circumferential measurements after operation immediately and at 12-month follow-up revealed increases of 1-2 cm. Conclusions The introduced technique for one-stage plastic procedure of penis lengthening and thickening indicates for treating micropenis and dysmorphophobia in terms of aesthetics or sexual function need . The new technique is a reliable method for penile augmentation with good configuration, satisfactory function and few complications.

0.05). Using Kaplan-Meier survival curves and the Log-rank test, statistic difference was found in patients with DNA diploid tumors and those with DNA aneuploid tumors (P

Four constitunets were isolated from the flower of Rhododendron molle ( BI. ) G. Don. One of these was named Rdl.The acute LD50 of Rdl in mice ( iv ) was found to be 4742 ug/kg.The hypotensive effect of Rdl was studied in various anesthesized animals. In cats, the dosage of 100, 300 and 500 Hg/kg of the Rdl ( iv ) reduced the blood pressure by 10:9% ( P

Atropine (Atr) ip 5 - 10mg/kg elevated the threshold dose of ouabain ( 10?g/min, iv ) to induce ventricular premature beats, ventricular tachycardia , ventricular fibrillation and cardiac arrest in guinea-pigs. Atr 2 - 4 mg/kg iv shortened the duration of arrhythmia elicited by Adr ( 40?g/kg, iv ) in conscious rabbits, & delayed the onset of arrhythmia evoked by AC ( 20?g/kg, iv ) or BaCl2 ( 2mg/kg, iv ) in anesthetized rats. It also decreased the incidence of arrhythmia induced by CaCl2 ( 102mg/kg, iv ) in rats. In mice, Atr ( 5~10mg/kg, ip)decreased the incidence of ventricular fibrillation by chloroform and artrial fibrill-ation ( or flutter ) by Ach-CaCl2.

Bepridil hydrochloride(Bep) hydrochloride is a new , long - acting antianginal and antiarrhythmic agent. Through the observation of ∑ST.NST.and NQ of ECG or nitro blue tetrazolium chloride staining, we studied the effect of Bep on liga-tion of the left coronary artery in rabbits and the myocardial ischemia induced by isopre-naline in rats. The results showed that in the groups treated with Hep andpropranolol theisoelectric level was facilitated. ∑ST.NST, NQ, thecreatine phosphokinase values and the weight percentage of infarcted myocardium were decreased. The myocardial ischemic injury was decreased by histopathological stud-