Objective To evalute the efficacy and safety of primary percutaneous coronary intervention (PCI) therapy and facilitated PCI therapy (thrombolysis plus PCI) for acute myocardial infarction (AMI). Methods Sixty four patients with ST elevation myocardial infarction (STEMI) were divided randomly into two groups including the facilitated PCI group and the primary PCI group. The patency rate of infarct-related artery (IRA) before intervention, the incidence of bleeding complications and acute ischemic events during hospitalization as well as the left ventricular ejection fraction (LVEF) measured by echocardiography before discharge were compared. The thrombolysis in myocardial infarction (TIMI) flow grade (TFG), TIMI myocardial perfusion grade (TMPG) and angiographic perfusion score (APS) in all patients were measured before and after PCI and the extent of ST segment elevation resolution was analyzed 90 minutes after reperfusion therapy. The relationship between APS and percentage of complete ST resolution was analysed by linear regression. Results The IRA patency rate and TMPG in the faciliated PCI group were significantly higher than that in the primary PCI group before PCI (P

Objective To investigate clinicians'practice and opinions on sedation therapy in end-stage patients at Peking Union Medical College Hospital.Methods From August,2022 to April,2023,an online questionnaire survey was conducted among clinicians involved in end-stage patient management.Results A total of 205 questionnaires were distributed,with an effective response rate of 56.1% .Among the clinicians,55.7% of them had experience of applying sedation therapy in end-stage patients;85.2% of clinicians believed that se-dation could relieve the suffering of terminal patients from physical refractory symptoms;75.7% of clinicians considered that sedation therapy could be used to relieve agony from psycho-existential distress.Most clinicians had concerns about sedation therapy due to the lack of legal support(86.1% )and the lack of understanding of patients or families(59.1% ).The majority(90.4% )of clinicians were willing to receive training on palliative sedation.Conclusions A majority of clinicians agree that sedation therapy could relieve the physical distress and psycho-existential distress in end-stage patients.However,most clinicians have concerns about the application of sedation therapy due to the lack of legal support.It is necessary to enhance the training on palliative sedation.