OBJECTIVE:To discuss the relation between sino-foreign cooperation mechanism and the internationalization of Chinese medicine products. METHODS: We discussed the positive correlation between sino-foreign cooperation mechanism and the internationalization of Chinese medicine products in theory and practice. RESULTS & CONCLUSION: The internationalization of Chinese medicine products can be achieved by setting up sino-foreign cooperation mechanism in Chinese medicine industry according to WTO regulations.

Objective:To investigate the curative effect and prognosis of schizophrenia patients treated with paliperidone extended -release tablets.Methods:Totally 72 cases of patients with schizophrenia were divided into the observation group (n=35) and the control group ( n=37 ) according to the order of admission .The obsevation group was treated with paliperidone extended-release tab-lets, while the controll group was treated with risperidone tablets , and both groups were treated for 8 weeks.The positive and negative syndrome scale(PANSS) was used to assess the effect of the two groups , the social function defect scale (SDSS) and prognosis of the two groups were compared.Results: After the 2-week treatment, the PANSS score, positive symptom score, negative symptom score and general symptom score were all decreased in the two groups when compared with those before the treatment (P<0.05),and the scores in the observation group were lower than those in the controll group (P<0.05).After the treatment, the SDSS was significantly reduced in the two groups when compared with that before the treatment (P<0.05), and the reduction in the observation group was more notable than that in the control group (P<0.05).The total effective rate of the observation group was 94.3%, which was higher than that (67.6%) of the control group (P<0.05).The incidence of adverse reactions, such as anxiety and akathisia, and the total adverse drug reactions in the observation group were both lower than those in the control group (P<0.05).Conclusion:Paliperidone extended-release tablets can effectively relieve suffering from schizophrenia with quick effect , few adverse reactions , high safety and good effect , which is worthy of promotion in clinical use .

Objective To compare the analgesic effect of Semen Persicae (SP, Taoren), Flos Carthami (FC, Honghua), Siwu Decoction (SD) and Tao Hong Siwu Decoction (THSD) in dysmenorrhea model and the acetic-acid-induced pain model. Methods The dysmenorrhea model and the acetic-acid-induced pain model were established, and the pain threshold was compared in different mice models. Results On dysmenorrheal model, the analgesic effect of water extract supernatant and ethanol suspension of FC, SP polysaccharide, water extract supernatant and ethanol extract of SD, SD and THSD polysaccharide differed from that of blank control. On acetic-acid-induced pain model, the analgesic effect of water extract supernatant and ethanol suspension of FC, FC polysaccharide, ethanol extract of SP, SP polysaccharide, SP+ FC water extract, SP+ FC ethanol extract, SP+ FC polysaccharide, SD ethanol extract, SD polysaccharide, THSD water extract and ethanol extract, and THSD polysaccharide differed from that of blank control. Conclusion FC water extract and ethanol extract, SP ethanol extract, THSD polysaccharide, SD ethanol extract and SD polysaccharide have the best analgesic action, and then come with THSD water extract and ethanol extract, SP + FC ethanol extract, and SP + FC polysaccharide.

Purpose:To investigate the features of midkine( MK) protein expression and the correlation between MK expression with angiogenes is and prognosis in non-small-cell lung cancer(NSCLC). Methods:Immunohistochemistry analysis for MK and microvessel de nsity(MVD) were performed on 44 samples of tumor tissue. Results:No positivity expression was detected in either the lun g tissue close to tumor or normal lung tissue,but 26 of 44 NSCLC tissue showed a positive reaction to MK immunostain. Significant correlation between MK express ion with MVD enhancement and lymph metastasis in NSCLC was found,and the surviva l terms in NSCLC with MK expression were significantly shorter than those in NSC LC without MK expression.The enhanced MVD was related to lymph metastasis signif icantly,and the survival terms in NSCLC with enhanced MVD were significantly sho rter than those in NSCLC without enhancement. Conclusions:In human non-small-cell lung cancer, MK overexpre ssion at the protein level may very well be closely related to angiogenesis and metastasis. MK protein may be one of the predictors for prognosis in NSCLC.

To study the alkaloid constituents in the seed of Sophora alopecuroides L. and isolation of lehmannine by transhydrogenation of sophocarbine to matrine present in the mixture. Methods　Various processes of exchange, ion exchange and column chromatograph with very similar physical and chemical properties was successfully separated by transhydrogenation. Results　5 alkaloids were obtained and identified by elementary analysis, IR, MS, 1HNMR and 13CNMR as oxymatrine, oxysophoridine, matrine, sophoridine and lehmannine (12, 13-dehydromatrine). Conclusion　Lehmannine was isolated from the seed of S. alopecuroides for the first time.

ObjectiveTo explore adrenal insufficiency in the preterm infants who had critical lung diseases and the relationship between adrenal insufifciency and long-term or short-term prognosis.Methods The basal cortisol and ACTH of iffty preterm infants enrolled were tested. The peak cortisol at 30 minutes after low dose ACTH stimulation was tested. The adrenal insufifciency was deifned as the concentration of the basal cortisol less than 15 μg/dl or the increment of cortisol concentration after low dose ACTH stimulation less than 9 μg/dl. The pretern infants with adrenal insufifciency were the AI group and others were the adrenal normality, AN group.Results Thirty-one cases were adrenal insufifciency in 50 preterm infants with critical lung disease. The incidence was 62%. The concentrations of the basal and peak cortisol in AI group were lower than those in AN group (P<0.01). The increment of cortisol concentration after low dose ACTH stimulation had not signiifcant difference between two groups. The concentration of ACTH in AI group was lower than that in AN group (P<0.01). The mean arterial blood pressure in AI group was lower than that in AN group (P<0.01). The blood sugar, potassium and sodium had no signiifcant difference between two groups (P>0.05). There was no signiifcant difference in the mortality and the incidence of BPD between two groups (P>0.05).Conclusions The incidence of adrenal insufifciency was high in the preterm infants with critical lung diseases, which may be due to insufifcient production of endogenous ACTH. When the adrenal insufifciency was happened, the blood pressure is relatively low in preterm infants with critical lung diseases, but it was not related to the mortality and the incidence of BPD.

Objective Cardiac valve replacement with cardiopulmonary bypass ( CPB ) can induce myocardial ischemia-reperfusion injury , which is bad for cardiac function recovery .The aim of the study was to evaluate the myocardial ischemia-reperfusion injury effect of breviscapine intravenously injected before CPB in patients undergoing cardiac valve replacement with CPB . Methods 40 patients scheduled for cardiac valve replacement were randomly divided into two groups :control group and breviscapine group ( n=20).Normal saline 15 mL and breviscapine 0.75 mg/kg was administered with pump within 30 mins after the induction of anesthesia in control group and breviscapine group respectively .Blood samples were taken from jugular vein at each of the five time points: before surgical incision (T0) and at 30mins, at 6, 12, 24h after aortic unclamping (T1-T4) for determination of plasma concentration of car-diac troponin-I (cTnI), creatine kinase isoenzyme (CK-MB) and superoxide dismutase (SOD). Results Compared with T0, the cTnI and CK-MB in both groups significantly increased at T 1-T4 and peaked at T 2 , the SOD in both groups significantly decreased at T 1-T4(P<0.05).Compared with control group, cTnI and CK-MB significantly decreased, while SOD activity significantly increased at T1-T4in breviscapine group (P<0.05). Conclusion The intravenous infusion of breviscapine 0.75 mg/kg before the staring of CPB can relieve myocardial ischemia-reperfusion injury in patients undergoing cardiac valve replacement with CPB , and the mechanism may be related to the anti-oxidative stress effect .

Objective To explore the correlation between BODE index with fatigue symptoms on COPD patients,and provide new ways for clinical evaluation,prediction,symptom control and establishment of effective management mode.Methods 120 COPD patients of stable stage were selected to be investigated and analyzed by the Fatigue Scale-14(FS-14),six-minute walking distance(6MWD),pulmonary func-tion test and the body mass index (BMI).Dyspnea was measured using the Medical Research Council (MRC) dyspnea scale.Results The fatigue symptoms showed high positive linear correlation with BODE index and mMRC,and significant negative correlation with 6 MWD,FEV1％ and BMI.Conclusions The study shows that fatigue symptoms had a higher prevalence in COPD patients of stable stage.There were a high correlation between fatigue symptoms with the BODE index,mMRC,6MWD,FEV1％ and BMI.The BODE index was a good predictor and evaluation of fatigue symptoms.

Objective To evaluate the effect of dexmedetomidine on inflammatory response and the changes of serum inflamma-tory mediator caused by cardiopulmonary bypass(CPB)in cardiac valve replacement surgery.Methods 30 patients scheduled for cardiac valve replacement were randomly divided into two groups:experimental group(n=15)and control group(n=15).For the experimental group,dexmedetomidine was infused intravenously with the dose of 2.0μg·kg-1 ·h-1 after induction of anesthesia. In control group,normal saline was given instead of dexmedetomidine.Blood samples were taken from radial artery in each of the following five time points:after induction of anesthesia(T1 ),the beginning of CPB(T2 ),after beginning of CPB 40 min(T3 ),after the termination of CPB 2 h(T4 )and 24 h(T5 )for determination of TNF-α、IL-6、IL-10.Results The concentration of TNF-α、IL-6、IL-10 levels showed no significantly difference between the two groups before CPB(P>0.05).But serum TNF-α、IL-6 levels of ex-perimental group were significantly lower and IL-10 were significantly higher than control group(P<0.05 or P<0.01)at the time points of T3~T5 .All biomakers rose significantly at the time of T3 and T4 in both groups(P<0.05 or P<0.01).At the time of T5 IL-6、IL-10 returned to preoperative levels(P>0.05)while TNF-αremained heigh level(P<0.05 or P<0.01)in both groups. Conclusion dexmedetomidine can regulate the release of the serum inflammatory mediator which suggest that dexmedetomidine may alleviate the systemic inflammatory reaction resulting from cardiopulmonary bypass in cardiac valve replacement surgery.

Objective To evaluate the value of high-frequency ultrasound for diagnosing Duchenne muscular dystrophy.Methods Eighty-one cases with Duchenne muscualr dystrophy were divided into four groups according to their age,age 3-7(13 cases),age 7-10 (30 cases), age 10-13 (30 cases),age 13-14 (8 cases). Twenty cases of healthy children, aged from 1 to 11 were chosed as controls. In all groups' buttock muscle,thigh and leg muscle were observed by high-frequency ultrasound longitudinally and horizontally.Results Gluteus atrophy and subcutaneous fat thickening were seen in age 3 patients,progressive subcutaneous fat thickening and progressive muscular atrophy of buttock,thigh and leg with age were proved.There were significantly differences among groups ( P