1.The Observation of the Voice Recovery from the Removal of Vocal Cord Polyp by Laryngomicrosurgery
Huadong MAO ; Jining QU ; Tao ZHOU
Journal of Audiology and Speech Pathology 1998;0(02):-
Objective To investigate the voice recovery by means of observing the changes of the acoustic parameters in the patients after vocal cord polyp operation by microlaryngoscope.Methods Follow up on the voice changes by means of morphology evaluations and voice analysis applied to 30 cases of patient with vocal cord polyp before the operation and in each week for 4 weeks after the operation.Results 86.67% patients were observed to have improved external appearance of their vocal cords 2 weeks after surgery.There is statistically significant difference in 2-,3-,4-week respectively after the operation compared with the preoperative group(P0.05).Conclusion 2 weeks is needed for the patients with vocal cord polyp to have improved vocal cords and one month needed at least to have the voicing functions recovered.Therefore the resting time should be proposed to patients with vocal cord polyp as a resting guideline.
2.The Study of the Postoperative Voice Rest Treatment for Patients with Vocal Fold Polyps
Cuie LI ; Tao ZHOU ; Jining QU ; Zezhang TAO
Journal of Audiology and Speech Pathology 2013;(5):497-500
Objective To study the voice rest treatment after laryngomicrosurgery in patients with vocal fold polyps .Methods Eighty -five patients with vocal fold polyps were divided into two groups randomly :Group A (48 cases) and Group B ( 37 cases) ,receiving 1 or 2 weeks voice rest postoperation ,respectively .Vocal acoustic analy-sis and fiberlaryngoscopy were performed in all patients before the surgery and 1 ,2 ,3 and 4 weeks after surgery . Results When compared with the preoperative data ,there were no significant differences in jitter ,shimmer and NHR 1 week after surgery in patients of two groups (P>0 .05) .Two weeks after surgery ,all the parameters im-proved significantly in Group B(P<0 .05) ,but only jitter improved in Group A (P<0 .05) .All the data in two groups returned to normal 4 weeks after surgery .Laryngoscopic examination showed varying degrees of vocal fold hyperemia and edema one week after surgery ,which then gradually subsided and gone .At 4 weeks after surgery , the appearance of the operative vocal fold completely returned to normal .Conclusion Patients with vocal fold polyps should be treated with complete voice rest for 2 weeks after surgery ,followed by 2 weeks of relative voice rest .This is beneficial to the voice recovering and the wound healing .
3.The inhibitory effect of N-p-chlorobenzenesulfonyl-4-aminosalicylic acid on dextran sodium sulfate-induced ulcerative colitis
Xue-qin ZHOU ; Chang SU ; Xiao-tong LI ; Xue-min YU ; Shu-wan QI ; Tao LIU ; Jing-mei ZHANG ; Jing YAO
Acta Pharmaceutica Sinica 2018;53(10):1652-1659
The study aims to explore the effects of N-p-chlorobenzenesulfonyl-4-amino salicylic acid on the dextran sodium sulfate (DSS)-induced ulcerative colitis in mouse. A total of 60 BALB/c mice were randomly divided into 6 groups (n=10):control group, DSS model group, 5-amino salicylic acid (5-ASA) group, and administration groups (N-p-chlorobenzenesulfonyl-4-aminosalicylic acid) 10, 20, 40 mg·kg-1. Model group were induced by drinking 4% (w/v) DSS solution for 7 days and normal water for the next 3 days. The positive group and drug group mouse were given 5-ASA (40 mg·kg-1) and N-p-chlorobenzene sulfonyl-4-amino salicylic acid (10, 20, 40 mg·kg-1) by gavage respectively. During the experiment, changes in body weight, bloody stool, fecal character and mental status were observed daily. Damage and repair of the colon mucosa and the pathological changes of important organs were observed by hematoxylin and eosin (HE) staining. Expression of inflammatory factors such as tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), macrophage inflammatory protein 2 (MIP-2), myeloperoxidase (MPO) in serum were detected by ELISA. The results showed that bloody stools and diarrhea emerged on the 4th day after model establishment in model mice. The number of bloody mice rose to ten, and blood and diarrhea began to appear in the administration group on the 7th day. Mental status was poor and body weight decreased significantly in model group since the 4th day, and the situation was improved in the administration group and 5-ASA group. Colons in the administration groups (10, 20, 40 mg·kg-1) were longer than those in the DSS model group. In the DSS model group, the colonic mucosa and submucosa of mice exhibited severe inflammatory cell infiltration, various degrees of necrosis, proliferation. In the middle dose group (20 mg·kg-1), the situation has improved slightly and the colonic mucosa showed mildly chronic inflammation and a small amount of inflammatory cells infiltration. The high dose group (40 mg·kg-1) showed normal colon mucosal, relatively complete epithelial structure and few inflammatory cell infiltration. The levels of IL-1β, IL-6, TNF-α, MIP-2 and MPO in the serum of mice were lower in the administration group (40 mg·kg-1) than in model group. Therefore, N-p-chlorobenzenesulfonyl-4-amino salicylic acid might be a feasible treatment for DSS-induced UC.
4.Psychotherapy combined with breathing training on the treatment of spasmodic dysphonia
Tao ZHOU ; Peixiang LEI ; Jining QU ; Yongmao CAO
Chinese Journal of Tissue Engineering Research 2005;9(12):224-225
BACKGROUND: The mechanism of spasmodic dysphonia(SD) is still unclear and lacks of confirmed diagnostic standards. Limited reports on the treatment mainly focused on botulinum toxin infiltration; recurrent laryngeal nerve section, and voice training, amongst which voice training has been considered as one of the ideal complementary therapeutic means for SD because of less side effects and complications.OBJECTIVE: To investigate the significance of voice training in the treatment of SD and provide a method for the clinical treatment.DESIGN: Clinical case analysis and retrospective study based on patients.SETTING: Department of otolaryngology and cerebral surgery in a university hospital.PARTICIPANTS: Thirty-six confirmed SD patients in Wuhan College affiliated Renmin Hospital from February 1985 to December 2002.METHODS: Psychological consultation combined with breathing and voice training was adopted to make patients breathe freely and coordinately, with breath pattern changed from deep chest breathing and reversal breathing to normal chest-abdominal combined breathing, which helped decreasing larynx muscle straining. All patients were followed up for one to two years and their therapeutic effects were assessed by normal phonation, improvement, and ineffectiveness.MAIN OUTCOME MEASURES: Assessment of therapeutic effects.RESULTS: All 36 SD patients achieved satisfactory outcomes after voice training, with SD completely recovered in 30 cases and obviously improved in 6 cases.CONCLUSION: Psychological consultation combined with voice training is an ideal approach for the rehabilitation of SD.
5.The vocal rehabilitation training for patients with spasmodic dysphonia
Peixiang LEI ; Jining QU ; Tao ZHOU ; Yongmao CAO
Chinese Journal of Physical Medicine and Rehabilitation 2003;0(08):-
Objective To explore the effect of vocal rehabilitation training on patients with spasmodic dys-phonia. Methods Thirty-six patients with spasmodic dysphonia were recruited, and psychotherapy, acupuncture,respiratory and vocal training were performed according to the patients condition to improve the coordination of the vo-cal organs. Interventions were also employed to convert the patients reverse or high locational pattern of respiration in-to the normal associated chest and abdomen respiration, so as to reduce the tone of the laryngeal muscle. ResultsSatisfactory effects were achieved by the rehabilitation training. 30 out of 36 cases recovered and the other 6 cases im-proved. Conclusion It indicated that the comprehensive vocal rehabilitation should be adopted for the treatment ofpatients with spasmodic dysphonia.
6.The Voice Acoustic Analysis of Unilateral Thyroid Adenoma Patient Underwent Thyroid Gland Lobectomy
Fei XIA ; Jining QU ; Cuie LI ; Tao ZHOU
Journal of Audiology and Speech Pathology 2010;18(2):140-143
Objective To investigate the characteristics of voice changes by multi-dimensional acoustic analysis in patients who underwent thyroid gland lobectomy without laryngeal nerve injury.Methods To observe vocal cord movement and evaluate voice quality,32 patients with unilateral thyroid adenoma received the examinations of fiberlaryngscopy and Multi-Dimensional Voice Program before and after operation,respectively.Forty subjects with normal voice were used as cantrol group.Results Fiberlaryngscopy examinations were normal in all patients before and after surgery.In thyroid group,the preoperative acoustic parameters in male patients showed no significant difference(P>0.05) compared with the control group.There was no significant difference between preoperative and postoperative acoustic parameters(P>0.05).While the postoperative acoustic parameters of female patients was significantly lower than those of preoperative and in control group(P<0.05).There was significant improvement 3 months after the operation compared with that of preoperative group(P<0.05).Fhi of 3 months after operation was still lower than those of preoperation and in control group in male and female patients that continues to be significant after 3 months.Conclusion Voice changes may occur after unilateral thyroid gland lobectomy without any laryngeal nerve injury,and there is little voice change in male patients,while in female patients,voice improvement is observed after operation.Fhi still remaines lower level for a certain of time.
7.The importance of preview and triage in emergence treatment for a large number of earthquake patients: a summary report from 2008 Sichuan Wenchuan Earthquake
Jining LIU ; Yong YANG ; Ruqi LV ; Tao ZHAO
Chinese Journal of Emergency Medicine 2008;17(7):681-683
Objective Preview and triage is significantly important in treating a large number of the wound-ed patients. Method From 12 May to 25 May, 2008, 2171 wounded patients from Wenchuan Earthquake weretaken to the Central Hospital of Mianyang. According to the injury degree, all the wounded were classified into se-vere, moderate and minor injuries, and wore red, yellow and blue label on the wrists (those who died in a shorting change, intramuscular injection of TAT after skin test. Emergency medical records, including examination re-sults and treatment time, were completed for each wounded. The severe wounded were transferred to the relevantried out in 985 wounded, 1418 wounded hespitalized, 13 died in emergency room within two weeks after earth-quake. Only 9 died of combined injury and 4 died of severe cerebral injury. Conclusions The preview and triagelet the emergence treatment effective for a large number of earthquake patients.
9.Impact of Myocardial Infarction and Abnormalities of Cardiac Conduction System on Sudden Cardiac Death.
Ru Ying SONG ; Run Tao DING ; Wen CUI
Journal of Forensic Medicine 2017;33(2):171-174
Sudden cardiac death (SCD), most commonly seen in coronary heart disease, is a kind of sudden death caused by series of cardiac parameters, which usually combines with myocardial infarction. However, some SCDs (including early myocardial infarction) happen suddenly and cause death in a very short time. In these circumstances, typical morphological changes are lack in macroscopic or microscopic fields, which make such SCDs become the emphasis and difficulty in the present research. SCD caused by myocardial infarction and abnormalities of cardiac conduction system (CCS) is related to atherosclerosis of coronary artery closely. This paper reviews cardiac dysfunction caused by myocardial infarction and diseases of CCS from morphology and molecular biology, and explores potential relationship between them. This paper aims to provide clues to the mechanism of myocardial infarction related sudden death and possible assistance for forensic diagnosis of SCD.
Coronary Disease
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Death, Sudden, Cardiac/etiology*
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Heart Conduction System/physiopathology*
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Humans
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Myocardial Infarction/physiopathology*
10.Study on diagnosis of atypical cerebral cysticercosis
Tao YU ; Feng-Quan XU ; Yan WANG ; Yu-Guang FU ; Jun DAI ; Ting-Xia FU
Chinese Journal of Schistosomiasis Control 2018;30(4):424-427