Objective: To investigate the efficacy of Tuina (Chinese therapeutic massage) plus "three-bridge" exercise for non-specific low back pain (NSLBP). Methods: A total of 80 patients with NSLBP were randomly divided into a control group and an observation group according to the random number table method, with 40 cases in each group. The two groups received Tuina treatment, and the observation group received an additional "three-bridge" exercise. The treatment lasted 4 weeks, and a follow-up evaluation was carried out 6 months after treatment. The visual analog scale (VAS), Oswestry disability index (ODI), and the Japanese Orthopaedic Association (JOA) scores for low back pain were used to evaluate patients' conditions before treatment, after 4-week treatment, and at the 6-month follow-up. Results: The total effective rate was 92.5％ and 85.0％ in the observation group, respectively, after 4-week treatment and at the 6-month follow-up, significantly different from the control group (P<0.05). After 4-week treatment and at the 6-month follow-up, the VAS, ODI, and JOA scores of the two groups were improved compared with those before treatment (P<0.05), and all the indicators in the observation group were significantly better than those in the control group (P<0.05). At the 6-month follow-up, the VAS, ODI, and JOA scores in the two groups were improved compared with those before treatment (P<0.05). Conclusion: Tuina plus "three-bridge" exercise can effectively alleviate pain, improve function, and have relatively sound long-term effects in treating patients with NSLBP.

Objective:To study the asaphia in children with ankyloglossia and the effect of articulation therapy after anaplasty.Methods:Articulation analysis by testing 21 shengmu and 8 yunmu, particularly the articulation involving front tongue was carried out in 16 healthy children and in 32 children with ankyloglossia before and after treatment.Among the 32 children with ankyloglossia 16 were treated with articulation training 1 month after operation(trained group),another 16 had the articutation test 2 months after operation(untrained group).Results:The articulation clarity in the children with ankyloglossia and in the healthly controls was 29.36 and 97.86 respectively(P

Objective To understand the strategy of schistosomiasis elimination and its effects in Jinhu County, Jiangsu Province. Methods The data of schistosomiasis control in Jinhu County at different stages from 1970 to 2017 were collected and analyzed. Results From 1970 to 2017, there were three stages of schistosomiasis control, including transmission control, transmission interruption, and monitoring and elimination stages in Jinhu County. The main measures included Oncomelania hupensis snail control, infectious source control, and health education. A total of area of 290 691.78 hm² was detected in Jinhu County, and the area with snails was 3 420.98 hm². There were 8 729.37 hm² area with snails was controlled. Since 2014, no O. hupensis snails were found. A total of 525 377 person-times were examined for schistosomiasis, with 2 815 schistosomiasis patients identified, and 2 844 person-times were treated by chemotherapy. In addition, 977 cases received the expand chemotherapy. Since 1990, no local schistosome-infected persons were found. In 2017, the awareness rate of schistosomiasis control knowledge and the correct rate of health behavior were increased by 54.59% and 14.23% respectively compared with those in 1992. Conclusions The comprehensive schistosomiasis control measures implemented in Jinhu County at different periods have achieved remarkable outputs and accelerated the schistosomiasis elimination process. However, the precise control measures should be implemented in the future to consolidate the prevention and control achievements.

Objective To provide the scientific guidance for the prevention of lead poisoning in the children ,the lead concentra‐tions in the blood of children in Xiamen are investigated .Methods 11 271 cases of outpatients with the age of 0 -10 years old in maternity and child care hospital were surveyed randomly .The lead concentrations in the blood of these children were determined by graphite furnace atomic absorption spectrometer .Results From 2010 to 2013 ,the whole blood lead levels of 11 271 children was detected .The mean blood lead levels was 51 .0 μg/L .The boy lead poisoning rate was higher than girls in different age groups ,the difference was statistically significant (P<0 .05) .Both the above indices increased gradually with the increase of age in the range of 1-6 years old ,and the mean blood lead levels reached its peak in preschool age ,the mean blood lead did not increased in school‐age children ,and the lead poisoning rate showed the downward trend .Conclusion The lead poisoning rate of children in Xiamen is close to the average level of other cities ,however ,the blood lead level tends to increase with the increase of age .The effect of lead pollu‐tion on physical health of children shall be paid more attention to nowadays .

To study on teaching method to improve the stomatology clinical operation skill,this article summarizes the advantages and disadvantages of multimedia and mutual action applied in stomatology clinical operation.Multimedia is a kind of super-media developing with the progress of computer techniques,and can increase positive study while the teaching method of mutual action can arouse enthusiasm in operation skill training of stomatology clinical skill,thus enhancing the efficiency of studying skill.

Objective To optimize the technological conditions of polysaccharide purification from compound Qianyu water decoction. Methods Water extraction and alcohol precipitation, resolution, Sevag method and dialysis method were used to purify polysaccharide.The purity of polysaccharide was measured with the phenol-sulfuric acid spectrophotometry.On the basis of single factor test, effects of redissolved solid-liquid ratio, number of protein removal, and dialytic time on polysaccharide purity of Qianyu were investigated by orthogonal test. Results The best conditions for purification of polysaccharide in Qianyu were as follows: liquid-solid ratio was 1:40(g/mL, W/V), remove protein for 10 times, and dialysis for 18 h.The content of polysaccharide could reach 69.04%, and the transfer rate was 51.84%. Conclusion The optimized purification process was simple and accurate.It can be used for polysaccharide purification in compound Qianyu water decoction.

Objective To assess the feasibility for the automated treatment planning verification system Mobius3D (M3D) to perform an independent 3D dose calculation in intensity-modulated radiotherapy (IMRT) for cervical cancer.Methods Twenty patients with cervical cancer were randomly selected.With treatment planning systems (Pinnacle,Version 9.2;Eclipse,Version 13.5),all IMRT plans were divided into 7 fields to meet the dosimetric goals.The optimized plans were exported to the M3D server.The percentage differences in the volume of region of interest (ROI) and the dose calculation of target volume and organ at risk (OAR) were evaluated for the two treatment planning systems,and theγ passing rate was used to assess the accuracy of M3D calculation.Results The difference in the volume of ROI for Pinnacle 9.2 to M3D was less than that for Eclipse 13.5 to M3D,with maximum differences of 0.22％±0.69％ and 3.5％±1.89％ for Pinnacle 9.2 and Eclipse 13.5,respectively.The differences in the dose calculation of target volume and OAR for the two treatment planning systems to M3D were within ± 1％.After recalculating by M3D,the dose difference between Pinnacle 9.2 and M3D was smaller than that between Eclipse 13.5 and M3D,but the mean differences were all within ±3％.The γ passing rates for target volume and OAR were more than 95％ on average.Conclusions The method of utilizing the automated treatment planning verification system to validate the accuracy of plans is convenient.It can be used as a secondary check tool to improve accuracy in IMRT dose calculation.

OBJECTIVE:To establish HPLC method for the determination of the content of paeoniflorin in Shenshao?gankang oral liquid.METHODS:Paeoniflorin was separated on Kromasil C 18 ;methanol-0.05mol/L KH 2 PO 4 solution-avantin(60∶173∶4,which was adjusted to pH=4.0with acetic acid)was taken as the mobile phase with a flow rate at1.0ml/min and detection wavelength at230nm.RESULTS:Good linear relationship was achieved when the detection concentration range of peoniflorin was0.027～0.230mg/ml(r=0.9999);The average recovery of peoniflorin was100.97%(RSD=1.28%,n=5). CONCLUSION:The method was simple,rapid,precise and reproducible,which can be used as the quality control of Shenshaogankang oral liquid.

Objective To evaluate the efficacy in treatment with transurethral electrocision for prostatic cyst.Methods A total clinical documents of 15 cases prostatic cyst treated with transurethral electrocision were analyzed retrospectively.All the cases were diagnosed confirmly by ultrasonography and CT,all the cysts closed to the prostatic urethra or intrude urinary bladder and all the patients underwent transurethral electrocision.Results All operations were performed successfully with operative time of 18-60 (36 ± 13) min.No blood transfusion during and after the operation and postoperative hospital stay was (5.2 ± 2.6) d.All the patients had been followed up for 6-24 months,the clinic symptom disappeared and no complications happened.Three months after the operation,IPSS decreased from (27.2 ±5.6) scores to (7.5 ± 1.6) scores and QOL decreased from (4.5 ± 1.1 ) scores to ( 1.6 ± 0.6) scores (P＜ 0.01 ),respectively.Qmax increased from (6.8 ±2.3) ml/s to (22.4 ±4.8) ml/s (P ＜0.01).Conclusion Transurethral electrocision is an effective therapeutic measure of prostatic cyst close to the prostatic urethra or intrude urinary bladder without so many complications.

Glioma is the most common primary intracranial tumor, and most patients present as glioblastoma, with high morbidity and mortality. The prognosis of patients with glioblastoma remains poor after surgical resection combined with standardized treatment of radiotherapy and chemotherapy. In recent years, although the breakthrough of immunotherapy have been achieved in the treatment of a variety of solid tumors, the existing data show that immunotherapy is not effective in improving the survival of patients with glioblastoma. However, studies have shown that immunotherapy can have a synergistic effect with radiotherapy which can increase antigen presentation and promote the formation of pro-inflammatory tumor microenvironment, providing more relevant targets for immunotherapy. The purpose of this paper is to discuss the effect of radiotherapy on tumor immune microenvironment and the role of radiotherapy combined with immune checkpoint inhibitors in the treatment of glioblastoma.