Objective:To improve students' knowledge and skills of AIDS prevention,analyze the effect of interactive peer education,and explore effective ways to carry out peer education.Methods:From September 2015 to May 2016,the freshmen in one college of Xi'an were investigated of AIDS knowledge,attitude and behavior using questionnaire as baseline data.Seven hundred peers of them received education with the methods of brainstorming,group discussion and questions,and case analysis.Then a questionnaire survey was conducted again to evaluate the effect of peer education.Results:After the intervention peer education,the scores of basic AIDS knowledge,prevention knowledge,relevant attitude and the rate of positive behavioral selection were significantly increased (P ＜0.05).Approximately 92.50％ of the students thought that having sex with only one partner can reduce the spread of AIDS and 81.76％ of the students were willing to help AIDS patients.Conclusions:Interactive peer education for college students has a good applicability,the effect is remarkable,and it is worth popularizing in colleges.