Objective To evaluate the effect of percutaneous stenting for renal artery stenosis. Methods Stent implantation was conducted in 27 patients(Interventional Group) with renal artery stenosis from January 1997 to December 2004 in this hospital.Patients' blood pressure,renal functions,and quality of life were recorded and compared with another group of 27 patients receiving medical treatment(Medical Group) during this time. Results The procedure of renal artery stenting was superior to the medical treatment in antihypertensive effect,renal function improvement,raise of life quality,and increase of survival rate.The procedure offered a high success rate(88.9%,24/27) and low re-stenosis rate(12.5%,3/24) and an incidence of complications(18.5%,5/27).The Interventional Group was remarkably superior to the Medical Group with respect to the decrease of blood pressure and creatinine and the increase of glomerular filtration rate,with significant differences.Follow-ups for 6 months ~ 8 years and 6 months(median,1 year and 9 months) revealed that normal daily activities and works were achieved in 19 patients in the Interventional Group and in 12 patients in the Medical Group. Conclusions Percutaneous renal artery stenting in the treatment of renal artery stenosis is effective.

Objective The 47 myocardial infarction patients (male 41, female 6, average ages 55 7?9 7 years) with silent myocardial ischemia (type Ⅱ SMI) were chosen The relationship was studied between the history of myocardial infarction (MI)and the degree of coronary arterial stenosis and the residual degree of stenosis after percataneous transluminal coronary angioplasty (PTCA) Methods All patients with MI were performed with exercise testing electrocardiogram to investigate the degree of myocardial ischemia The patients were also studied the degree of coronary arterial stenosis before and after PTCA Results The results showed before PTCA, the degree of the patients′ coronary arterial stenosis with a period of no more than three months of MI was higher than that of those patients′ with a period of over three months( P

Objective To evaluate the clinical and stenting relating risk factors on the in-stent restenosis. Methods One hundred and thirty seven patients whose data were available were enrolled in this study, and the patients were divided into the groups of in-stent restenosis and non in-stent restenosis according to the results of coronary angiograms. Then the clinical and stent relating factors affecting in-stent restenosis were analyzed. Results There were no statistical differences in age and prevalence of smoking, drinking, hypertension and diabetes mellitus between two groups. Narrowing of target coronary vessels before the procedures in the group of in-stent restenosis was more severe than that in the group of non in-stent restenosis ( vs , P=0.033). The average diameter of stents used in the group of in-stent restenosis was obviously smaller than that used in the group of non in-stent restenosis ([3.19?3.90]mm vs mm, P=0.005), the average length of stents, however, used in the group of in-stent restenosis was apparently longer than that used in the group of non in-stent restenosis ([21.91?8.98]mm vs [18.20?6.07]mm, P=0.011). The total duration of stent inflation in the group of in-stent restenosis was obviously shorter than that in the group of non in-stent restenosis ([22.74?19.56]s vs [29.12?25.72]s, P=0.026). There was no statistial difference between the two groups in the inflation times and pressure of stents implantation. Conclusion The results suggested that the rate of in-stent restenosis was not significantly influenced with age, smoking, drinking, hypertension, diabetes mellitus and inflation times and pressure of stent implantation, but the narrowing of target vessels before procedures and the lengths of the stents were positively related to in-stent restenosis, while stent diameters and total inflation durations of stent were negatively related to in-stent restenosis.

Objective To manifest the angiogenic effect and heart function improvement of transplantation therapy through the experiments of porcines. Methods The coronary arteries of porcines were ligated to create myocardial infarction and then the bone marrow mononuclear cells were injected into the coronary artery. Three weeks after transplantation the heart function was measured by echocardiography and left ventricular angiography. The myocardial blood perfusion was measured by single photon emission computerized tomography. The number of microvessels was also counted. Results After the injection of bone marrow mononuclear cells, left ventricular angiography showed the increasing of dP/dt. The myocardial blood perfusion measured by single photon emission computerized tomography increased. Collateral vessels occurred, and the number of vessels was higher than that of the control (56.6?11.7/mm2 vs. 37.2?8.4/mm2,P

Objective To evaluate the predictive value of electrocardiogram in localizing the occlusion site in the left anterior descending coronary artery(LAD) in acute anterior myocardial infarction(AMI).Methods According to the coronary angiogram,all patients with AMI were divided into two groups:one(the PS group) was a collection of patients(n=61) whose occlusion sites were proximal to the first septal branch(S1) and the other(the DS group) was a collection of patients(n=40) whose occlusion site were distal to S1.Diagnostic sensitivity and specificity in prediction of the occlusion site in LAD were calculated based on the measurements and incidence of ST segments deviation on electrocardiogram(ECG).Results The sensitivity and specificity for prediction of occlusion site being proximal to S1 in LAD using ECG were as follow:43% and 85%(P=0.004) for ST elevation in lead aVR,16% and 97%(P=0.031) for ST elevation≥1.5 mm in lead aVL,39% and 85%(P=0.009) for ST depression≥1.0 mm in lead Ⅱ,23% and 98%(P=0.005)for ST depression ≥2.0 mm in lead Ⅲ,38% and 88%(P=0.006) for ST depression ≥1.0 mm in lead aVF,20% and 86%(P=0.037) for ST depression in lead V5,18% and 100%(P=0.005) for ST elevation in lead aVR together with ST depression in leads V5,30% and 93%(P=0.008) for ST elevation in lead aVR together with ST depression in leads V6.The sensitivity and specificity for diagnosis of occlusion site being distal to S1 were 53% and 90%(P=0.000)ST elevation or unchanged in lead Ⅲ,50% and 82%(P=0.001) for ST elevation in lead V5.There were no significant difference in infarction size and left ventricle ejection fraction between the two groups.Conclusion(1) ST elevation in lead aVR together with ST depression in leads V5 and V6,obvious ST depression in the inferior leads,and ST elevation in leads I and aVL were all indication of occlusion in LAD proximal to S1.(2) ST elevation or unchanged in inferior leads(especially in lead Ⅲ),and marked ST elevation in lead V5 indicated that the occlusion site in LAD was distal to S1.

ObjectiveTo evaluate the curative effect of supplementedGanmai-Dazaodecoction for malignant tumor correlation with depression.MethodsA total of 98 patients with malignant tumor-related depression were divided into a treatment group and acontrol group according to the random number table. The control group were treated with flupentixol and melitracen tablets (Deanxit) combined with conventional treatment, the treatment group were treated with oral administration of traditional Chinese medicine supplemented Ganmai-Dazaodecoction combined with conventional treatment for 8 weeks. The Hamilton Depression Scale (HAMD) was used to evaluate the curative effect.ResultsThe effective rate showed no significant difference between the treatment groupand the control group (79.59%vs.75.51%;χ2=0.059,P=0.809). HAMD scores in both groups were significantly decreased after the treatment than before treatment (12.8±3.4 vs. 29.4±4.7 in the treatment group, 12.3±3.6vs.28.7±4.5 in the controlgroup, allP<0.05), there was no significant difference in HAMD scores after the treatment between the treatment group and the control group (t=0.707,P=0.481). ConclusionCurative effect of supplementedGanmai-Dazaodecoction is equal to flupentixol andmelitracen tablets in patients with malignant tumor-related depression.

Objective To investigate the significance of homocysteine (Hcy) in pathogenesis of coronary heart disease (CHD) and the relationship among serum homocysteine , age, type of CHD and the branches of coronary arteriopathy. Methods In a cross sectional test, serum Hcy levels of 166 old cases (age≥60 years) and 161 non old cases(age

Objective: To observe the effects of sodium heparin and low molecular weight heparin on the release of plasma hepatocyte growth factor (HGF) in senior coronary heart disease patients.Methods: Fifty-four senior patients with coronary heart disease were divided into three groups: intravenous sodium heparin, subcutaneous sodium heparin, and subcutaneous low molecular weight heparin (LMWH). Plasma HGF and vascular endothelial growth factor (VEGF) were measured before and after injection.Results: Plasma HGF was increased rapidly and significantly after intravenous injection of sodium heparin, reaching its peak level (about 48 fold) after approximately 10 minutes. Plasma HGF was also increased rapidly and significantly after subcutaneous injection of sodium heparin and LMWH, reaching its peak level (about 4 and 5 fold in sodium heparin and LMWH respectively) after approximately 2-3 hours. Conclusion: The rise of plasma HGF after heparin treatment suggests that heparin has some other biological effects in addition to its anticoagulant property through HGF. By this mechanism, the administration of heparin may be of some importance in the reparation of cardio-vascular diseases.

Objective:To explore the related factors of ventricular arrhythmia (VA) complicating acute phase of myocardial infarction and their effects on short term prognosis. Methods:A total of 161 subjects with acute myocardial infarction (AMI) were divided into 5 groups according to VA types: frequent single ventricular premature beat group(n=10),bigeminy or paired ventricular premature beat group (n=21),non-sus- tained ventricular tachycardia group (n=31),ventricular tachycardia and fibrillation group (n=11) and control group (n=88). The characteristics of coronary artery and left ventricular ejection fraction were determined. Results:The incidence of left main coronary occlusion was more frequent in ventricular tachycardia and fibrillation group than in control group (P

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of adult lymphoma and is a group of invasive and heterogeneous diseases. Although rituximab in combination with CHOP regimen (R-CHOP) for DLBCL is better, one third of patients have relapsed/refractory conditions. DLBCL is divided into many subtypes due to its high heterogeneity. Different histological types have different response to treatment. High-risk DLBCL has little effect on R-CHOP treatment. How to further improve the first-line cure rate of high-risk DLBCL has become an important challenge in the field of lymphoma treatment. Currently in the era of precision medicine, in recent years, many new targeted drugs, such as immunosuppressive agents, mammalian target of rapamycin (mTOR) receptor inhibitors and Bruton tyrosine kinase (BTK) inhibitors, have been developed for DLBCL-related pathways and molecular targets, provide more new possibilities for the treatment of DLBCL.