With the improvement of people's living standard,the occurrence of children obesity is also increasing.Children obesity not only affects children' s growth,but also is closely related to the occurrence of many diseases in adults.Therefore,prevention and treatment of child overweight and obesity are very important for improving people's health.This paper summarizes several childhood obesity intervention in recent years.

Objective To observe the effects of 1,3-dipropyl-8-cyclopentylxanthine(DPCPX),an adenosine A1 receptor antagonist,on brain neurons damage induced by hypoxia and reoxygenation(H/R),and to elucidate the relevant mechanisms.Methods An in vitro cultured rat cerebral cortical neuronal H/R damage model was established;the effects of DPCPX were detected at final concentrations of 0(control),25,50,100nmol/L on the lactate dehydrogenase(LDH) release from normoxic neurons and H/R neurons which were treated with hypoxia for 8,12,24 hours followed by reoxygenation for 24 hours;the changes of malondialdehyde(MDA) content,activities of xanthine oxidase(XO) and Ca2+-ATPase in H/R neurons which were treated with hypoxia for 12 hours and reoxygenation for 24 hours brought by administration of DPCPX at the concentration of 100nmol/L were also determined by use of specific reagents.Results With addition of 100nmol/L DPCPX,the LDH release from H/R neurons which were treated with hypoxia for 12 hours and reoxygenation for 24 hours was significantly increased compared with that in control group(P

Extranodal NK/T cell lymphoma,nasal type is a common subtype of non-Hodgkin's lymphomas in China.Many difficulties remain in its diagnosis and treatment.Correct diagnosis can be established according to the typical histology findings and immunology phenotypes with CD33（E）,EBER and/or CD56 positive.Prognostic factors should be assessed in the initiation of diagnosis.Ann Arbor staging classification has still being widely used and PET-CT scan is strongly recommended.Chemotherapy followed by radiotherapy should been considered for early-stage patients and combined chemotherapy is the best choice for advanced stage patients.The regimens containing L-asparaginase should be considered firstly due to the evidences from many clinical trials.Stem cell transplantation is recommended to almost all patients except for IE stage patients without any unfavorable prognostic factor.New regimens should be investigated and assessed in the perspective randomized clinical trials.

Extranodal NK/T-cell lymphoma,nasal type (ENKTL) is a aggressive lymphoma which arises from NK cells or T cells and has a poor prognosis.This article mainly reviewed and focused on hematological stem cell transplantation in treating ENKTL.

OBJECTIVE:To observe clinical efficacy and safety of Ginkgo biloba extract combined with olmesartan me-doxomil in the treatment of essential hypertension,and to discuss its effect on the expression of serum protein. METHODS:98 pa-tients with essential hypertension were selected and randomly divided into observation group A and observation group B,with 49 cases in each group;40 healthy volunteers were included in control group. Observation group A was given Olmesartan medoxomil tablet 20-40 mg,po,qd;observation group B was given Olmesartan medoxomil tablet 20-40 mg,po,qd+ Extract of G. biloba leaves tablet 40-80 mg,po,bid. Treatment course lasted for 4 weeks. Blood pressure(SBP and DBP),TCM symptom score,the repeti-tiveness and resolution ratio of 2-DE spectrum,protein differentiation expression point,related information of differentiation expres-sion protein in 3 groups and ADR of observation group were observed. RESULTS:After treatment,SBP,DBP and TCM symptom score of observation group were significantly lower than before;those indexes after 4 weeks of treatment were significantly lower than those after 2 weeks after treatment;the observation group B was significantly lower than the observation group A,with statisti-cal significance(P<0.05). The repetitiveness and resolution ratio of protein differentiation expression point in observation group B were significantly better than in observation group A after treatment. The expression of 15 protein points in observation group down-regulated before treatment,and up-regulated after treatment to different extents;the observation group B was closer to control group,compared to observation group A. The expression of 6 protein points up-regulated,and then down-regulated to different extent after treatment;the observation group B was closer to control group,compared to observation group A. A total of 11 protein points were identified. There was no statistical significance in the incidence of ADR between observation group A and observation group B (P>0.05). CONCLUSIONS:G. biloba extract combined with olmesartan medoxomil greatly influences the expression of serum pro-tein in patients with essential hypertension and shows good antihypertensive and pressure-control effects with good safety.

Neuroendocrine cells comprise a minor subpopulation of the normal prostatic epithelium. When patients accept the androgen deprivation therapy, it will induce neuroendocrine differentiation of the prostate carcinoma cells. NE cells can provide endocrine/paracrine stimuli for proliferation of the surrounding carcinoma cells and inevitably make prostate cancer become androgen independent and no longer responsive to hormonal manipulation. In this paper, the mechanism of neuroendocrine differentiation and its relationship with androgen independent state were reviewed.

目的观察苁蓉通便汤治疗老年性便秘的临床疗效。方法将 62例老年性便秘患者分为两组。治疗组(32例)内服苁蓉通便汤,对照组(30例)内服麻仁润肠丸。结果治疗组疗效优于对照组(P<0.05)。结论苁蓉通便汤对老年性便秘疗效显著。

OBJECTIVE:To study the preventive effect and mechanism of butylphthalide on myocardial ischemia-reperfusion injury in rats. METHODS:SD rats were randomly divided into sham operation group,model group,butylphthalide low-dose,me-dium-dose,high-dose groups (50,75,100 mg/lg),10 in each group. All rats were intragastrically administrated related drugs once a day,sham operation group and model group were intragastrically administrated equal amount of normal saline,for 3 d. Af-ter last administration,except for sham operation group,120 min of repertusion was conducted. Ratio of myocardial infarction ar-ea, apoptosis rate of myocardial cells, expressions of apoptosis-related protein [proapoptotic proteins (Caspase-3, Fas, Cas-pase-9),apoptotic protein (Bcl-2)],left ventricular ejection fraction (LVEF),and content of vascular endothelial growth factor (VEGF)in serum of rats in other groups were detected. RESULTS:Compared with sham operation group,myocardial infarction ar-ea and apoptosis rate of myocardial cells in model group were obviously increased;expressions of Caspase-3,Fas,Caspase-9 pro-tein in myocardial cells were obviously enhanced,Bcl-2 protein expression was obviously weakened;LVEF and serum VEGF con-tent were obviously reduced (P<0.01). Compared with model group,except that LVEF in butylphthalide low-dose group didn't changed obviously (P>0.05),above indexes in other administration groups improved obviously (P<0.05). Compared with bu-tylphthalide low-dose group,myocardial infarction area and apoptosis rate of myocardial cells in butylphthalide high-dose group were obviously decreased(P<0.05);expressions of Caspase-3,Fas,Caspase-9 protein in myocardial cells in butylphthalide medi-um-dose,high-dose groups were obviously weakened,and Bcl-2 protein expression was obviously enhanced(P<0.05). CONCLU-SIONS:Butylphthalide can effectively reduce myocardial ischemia-reperfusion injury in rats,protect cardiac functions,and its mechanism may be related with up-regulating VEGF.

The high frequency key words in papers on reading therapy published in China were selected, the fre-quencies of co-words presenting in a paper were calculated, and the established matrix of co-words was trans-formed into correlative matrix and diversity matrix, respectively.The diversity matrix was analyzed by cluster analysis and the hot research spots in papers on reading therapy published China were studied.

Objective To study previous cesarean section effects on re-eesarean section, and to seek better operation way of cesarean section. Methods The conditions of entrance into abdominal cavity and adhesion of 452 cases of abdominal cavity were retrospectively analyzed. The information about initial operation was investigated, dis-covering 104 cases underwent new type,and 348 cases underwent improved cesarean section. Results Time of en-trance into abdominal cavity once more by new type of cesarean section were (9.25±2.27) min and the incidence of adhesion in abdominal cavity was 18.27%,while time of entrance into abdominal cavity once more by improved cesarean section were (7.23±2.21) min and the incidence of adhesion indominal cavity was 9.87% (u=8.016, P<0.05; χ25.57,P<0.05). Conclusion New type of improved cesarean section has little effect on re-cesarean section, worthing more clinical practice.