1.SERUM MANGANESE, CHROMIUM, ZINC AND COPPER LEVELS IN CORONARY HEART DISEASE
Xiong ZOU ; Deen GAO ; Jingtao PAN
Acta Nutrimenta Sinica 1956;0(03):-
The serum manganese, chromium, zinc and copper levels of 63 cases with coronary heart disease and 33 normals were determined by the inductively couple plasma emission spectroscopy. The concentrations of Mn, Cr, Zn and Cu were 0.02145 ?0.0107 ppm, 0.0230 ?0.0167 PPm, 0.905?0.278 ppm 1.056 ?0.404 PPm and the Cu/Zn ratio was 0.973 ?0.395 in normals.In comparing with normals, a significant increase in the serum zinc concentration (P
2.THE EFFECTS OF THYROID HORMONE ON GONADOTROPIN SECRETION IN RAT′S PITUITARY CELLS
Jingtao DOU ; Changyu PAN ; Ming LI
Medical Journal of Chinese People's Liberation Army 2001;0(12):-
In order to investigate the effects of thyroid hormone on gonadotropin secretion in rat pituitary cells,the cultured rat pituitary cells were exposed to a series of concentrations of T 3 (0, 0 001, 0 01, 0 1, 1 and 10?g/ml). rLH and rFSH were determined after exposure to of T 3 The secretion ability of pituitary cells of rats with different thyroid function was evaluated in vitro. The results showed that high concentrations of T 3 (1 and 10?g/ml) inhibited the secretion of rLH ( P
3.Analysis of glucose dysbolism in patients with ectopic ACTH syndrome
Lei ZHAO ; Yiming MU ; Jingtao DOU ; Juming LU ; Changyu PAN
Chinese Journal of Endocrinology and Metabolism 2008;24(4):410-411
The characteristics of glucose dysbolism in ectopic ACTH syndrome (EAS) were investigated by analysing the clinical data of 117 patients with Cushing syndrome (CS). The patients with CS were divided into 3 groups : EAS group (n = 9) , Cushing's disease (CD) group (n = 67) and adrenocortical adenoma (AA) group (n =41). Retrospective analysis of the data covered the prevalence of secondary diabetes, blood glucose, HbAlc, blood potassium, and blood ACTH and 24 h urinary-free cortisol (UFC) levels. Compared with CD and AA groups, the prevalence of secondary diabetes and blood glucose level were higher in EAS group, while HbAlc level was lower. Blood glucose level in patients with ectopic ACTH syndrome decreased to normal after tumor removal.
4.Comparison of the clinical features in ectopic ACTH syndrome and Cushing′s disease with hypokalemia
Zhaohui LU ; Juming LU ; Wensheng JIN ; Jingtao DOU ; Yiming MU ; Changyu PAN
Chinese Journal of Endocrinology and Metabolism 2001;0(05):-
Objective To study the clinical features of the ectopic ACTH syndrome in order to increase the early diagnostic rate. Methods Clinical features and imaging diagnosis of 8 consecutive patients with ectopic ACTH syndrome were described and laboratory data were compared with those of 16 consecutive patients with ACTH-dependent Cushing′s syndrome accompanied with hypokalemia. Results The ectopic ACTH syndrome occurred in 11.3% of all patients with Cushing′s syndrome and the common causes were lung cancer and bronchial carcinoid. The clinical features of the ectopic ACTH syndrome differ from those of ACTH-dependent Cushing′s syndrome. Ectopic ACTH syndrome occured predominently in men and showed the duration of symptoms less than 5 months and a more rapid clinical course. There were apparent muscle weakness, edema of lower extremities, higher plasma ACTH and free cortisol (F), severe metabolic alkalosis and more negative responses to the high dose of dexamethasone suppression test. Chest X-rays and CT were helpful for tumor localization. The prognosis depended on whether the tumor was malignant or benign, and complete surgical resection of tumor was the key treatment. Conclusion Ectopic ACTH syndrome could be distinguished from the ACTH-dependent Cushing′s syndrome with hypokalemia according to the clinical features, laboratory data, plasm ACTH and F levels, as well as chest X-rays and CT.
5.Evaluation of the superiority of glargine as basal insulin replacement by continuous glucose monitoring system
Xianling WANG ; Juming LU ; Changyu PAN ; Yiming MU ; Jingtao DOU ; Jianming BA
Chinese Journal of Endocrinology and Metabolism 1986;0(04):-
With the continuous glucose monitoring system, daily blood glucose profiles were compared in type 2 diabetic patients treated with glargine or neutral protamine hagedorn (NPH) at bedtime for 12 weeks. The blood glucose levels in these patients were previously not well controlled with sulfonylureas. The results suggested that combined treatment with glargine before bedtime showed less nocturnal hypoglycemia and more stable blood glucose profile with less excursion when fasting blood glucose levels were well controlled.
6.Clinical analysis of 7 patients with Paget's disease of bone
Xianling WANG ; Guang YANG ; Juming LU ; Jingtao DOU ; Yiming MU ; Junhua MENG ; Changyu PAN ; Huaiyin SHI
Chinese Journal of Endocrinology and Metabolism 2008;24(4):412-414
Clinical and imageological characteristics of Paget's disease of bone in 7 patients who were treated in our hospital from 1991 to 2007 were analyzed. The data showed (1) 6 patients had the symptoms of bone pain and bone deformity, with more long bones involved; (2) Serum alkaline phosphatase was over normal range; (3) Imageology showed that osteoclasia was usually combined with bone sclerosis; (4) All the patients were treated with bisphosphonates; (5) 2 patients with serious bone deformity were treated with orthomorphia. Paget's disease of bone is a kind of metabolic bone disease with the characteristics of osteoclasia combined with bone sclerosis. The main features are bone pain and bone abnormality. Bisphosphonates are the first choice of drugs. Patients with serious bone deformity should be treated with orthomorphia.
7.Clinical and epigenetic study of a case with adrenal hypoplasia congenita caused by a novel DAX-1 gene mutation
Yuping GONG ; Guang XING ; Baoan WANG ; Lijuan YANG ; Jingtao DOU ; Yiming MU ; Juming LU ; Changyu PAN
Chinese Journal of Endocrinology and Metabolism 2009;25(1):62-63
Hormones and epigenetic characteristics in a patient with clinically diagnosed adrenal hypoplasia congenita (AHC) were analyzed. Results indicated that plasma ACTH increased, while cortisol, testosterone, LH and FSH decreased. LH, FSH and testosterone did not sufficiently respond to GnRH or hCG stimulation. Gene analysis indicated that C368F mutation was located in exon 1 of DAX-1 gene.
8.Association of toxic thyroid adenoma with acromegaly: one case report and literature review
Weijun GU ; Jingtao DOU ; Guoqing YANG ; Zhaohui LU ; Jianming BA ; Yiming MU ; Juming LU ; Changyu PAN
Chinese Journal of Endocrinology and Metabolism 2012;(11):901-905
Hyperthyroidism and acromegaly formed an unusual association.An acromegaly patient with a toxic thyroid adenoma was reported here,including clinical features,treatment,and final outcomes.The association of thyroid disease with acromegaly was reviewed.
9.Multiple endocrine neoplasia type 1 presenting as hypoglycemic coma :a report of four cases and review of literatures
Xianling WANG ; Juming LU ; Jingtao DOU ; Yiming MU ; Zhaohui LU ; Qinghua GUO ; Jianming BA ; Changyu PAN
Chinese Journal of Internal Medicine 2009;48(1):13-16
Objective To investigate the clinical characteristics of multiple endocrine neoplasia type 1(MEN1)patients presenting with hypoglycemic coma as chief manifestation and the related clinical experience in diagnosis and therapy.Methods We analyzed the clinical data of 4 patients who were hospitMized because of recurrent hypoglycemic coma and diagnosed as having MEN1 by endocrinolgical,radiological and pathological examinations.Results In the 4 cases of Whipple trilogy,radiological examination showed occupying lesion in the pancreas and pathological examination confirmed the diagnosis of insulinoma.In 2 cases the insulinomas were multiple.In this series,one cage was complicated with pituitary adenoma,parathyroidoma(recurrent after operation)and adrenocortical adenoma,one case with pituitary adenoma,parathyroidoma(2 tumors)and adrenal nodular hyperplasia,one case with pituitary adenoma and parathyroidoma,and the remaining one with pituitary adenoma and suspectable parathyroidoma.Conclusions For patients with insulinoma,MEN1 should be considered.In patients with MEN1,the presence of multiple or ectopic Darathymid adenomas(or hyperplasia)and insulinomas should be inspected during operation.After operation,examinations should be regularly performed to identify whether the diseases relapse or new endocrine neoplasias occur.
10.Clinical study on desmopressin acetate therapy in patients with adipsic hypernatremia: Five cases report
Qinghua GUO ; Juming LU ; Yiming MU ; Jingtao DOU ; Xianling WANG ; Guoqing YANG ; Weijun GU ; Zhaohui LV ; Changyu PAN
Chinese Journal of Endocrinology and Metabolism 2010;26(12):1054-1057
Objective Adipsic hypernatremia is very rare in clinical practice and only a few cases have been reported so far. Since the pathogenesis of adipsic hypernatremia is unclear, therapeutic method is very limited and uncertain. We previously found the existence of partial central diabetes insipidus in the patient with adipsic hypernatremia according to a series of clinical studies. In this clinical study, we observed the response of vasopressin in the treatment of adipsic hypernatremia as a routinely used agent in treating central diabetes insipidus.Methods Five patients with chronic sustained hypernatremia and hypodipsia were diagnosed as adipsic hypernatremia according to the criteria by Halter. After testing plasma electrolytes, urinary osmolality, plasma osmolality, and free water clearance (CH2O);with evaluating thirsty grade and anterior pituitary function, patients were forced to drink water 2 000-2 500 ml each day combined with prednisone and/or levethyroxin supplementation therapy if hypopituitarsm was revealed. One week later, since the hypernatremia was unrelieved, desmopressin acetate (0.05-0.2 mg/d)was administered to those 5 patients. About 5-7 days later, plasma electrolytes, urinary and plasma osmolality, and free water clearance ( CH2O ) were reevaluated. Osmolality was detected by the method of freezing point depression and thirst grade by the method of visual analogue scales. Results The plasma sodium was 160-190 mmol/L and plasma osmolality was 330-370 mmoL/L without thirsty perception during the hospitalization. Four of the five patients were revealed to be suffering from hypopituitarism, but the hypernatremia could not be corrected by intentional water intake combined with prednisone treatment. After administering vasopressin 0.05-0.2 mg/d to these patients, that hypernatremia was relieved, and hyperosmolality and hypodypsia were improved effectively. During this period of time, no side effects were detected in these patients. Conclusion We testified the existence of central partial diabetes insipidus in the patients with adipsic hypernatremia. Desmopressin acetate in the treatment of adipsic hypernatremia is proved to be effective, simple, and safe.