OBJECTIVE: To establish the quality standard of Yishen granules.METHODS:Polygonum multiflorum,Ganoderma,Radix Astragali and Angelica sinensis in the formulation were identified by TLC.The content of stilbene glucoside in polygonum multiflorum was determined by HPLC.RESULTS: The TLC identification method exhibited good specificities.The samples were similar to the references /control in that their TLC spots assumed identical color at the corresponding places,yet without the interference form the negative samples.The linear range of stilbene glucoside was 0.037 75～0.755 ?g(r=0.999 5) and the average recovery was 99.44%(RSD=1.79%,n=6).CONCLUSION: The established standard is accurate,reliable and applicable for the quality control of Yishen granules.