Objective The article was to speed up the dissolution rate of poorly soluble drugs, reduce the configuration time and improve the allocative efficiency by analysis on factors influencing dissolution and adoption of proper allocative approaches accord-ing to different characteristics of insaluble drugs. Methods 5 insaluable drugs were chosen for the study, which were ornithine as-partate, mezlocillin sodium and sulbactam sodium, teicoplanin, omeprazole sodium injection and imipenem and cilastatin sodium.The control group were allocated by routine configuration approach, while the experiment group were improved by increasing the amount of solvent, loosing the powder inside the bottle before configuration, reducing the bubble, adopting special solvent and increasing the dis-solution temperature.Observation and comparative experiment were made on two groups along with the timing from configuration to com-plete dissolution into clear transparent liquid. Results As to the average complete dissolution time of 5 drugs, significant difference was found between two groups([42±5]s vs [246±35]s, [3±1]min vs [30±3]min, [5±1]min vs [10±3]min, [5±3]min vs [10± 5]min, [2±1]min vs [10±1]min, P<0.05).Compared with the control group, the dissolution time of 5 drugs was cut down by 83%, 90%, 50%, 50%, 80%in experiment group. Conclusion Appropriate increase of solvent, loose powder, bubble reduction, special solvent and increased solution temperature contribute to shortening the dissolution time of insoluble drugs and improving the configura-tion efficiency of pharmacy intravenous admixture.

Objective To investigate the value of urinary bladder temperature monitoring among patients with cardiac surgery, and provide reference for clinical perioperative temperature nursing. Methods A total of 60 patients undergoing open cardiac surgery of beating coronary artery bypass grafting ( 30 with extracorporeal circulation and 30 without extracorporeal circulation) were included in our study during the period of October 2010 to October 2013. Body temperature was monitored at 9 time points during the operation at urinary bladder (BT), rectum (RT), lower esophagus (LT) and nasopharynx (NT), axillary cavity (AT), and compared and analyzed with standard blood temperature ( BT ) after inserting Swan-Ganz catheter. Results During open cardiac surgery of without extracorporeal circulation, different time of BT, RT, NT, LET had a uniformity of temperature change with blood temperature with no statistical significance (P>0. 05), but the AT was lower than BT. In the open cardiac surgery of extracorporeal circulation, the differences between UT, LT, RT and BT had no statistical significance during constant temperature period (P>0. 05). During the rapid decrease phase of BT and end of rewarming phase, we painted Bland-Altman picture for different part of body temperature with BT, found that the the difference between LT and BT were ( -7. 23 ± 2. 70 ) and (0. 25 ± 1. 05)℃, the difference between RT with BT were ( -1. 38 ± 1. 19),(0. 96 ± 2. 11)℃, and the difference between UT and BT were (0. 37 ± 1. 24),(0. 52 ± 1. 28)℃. Conclusions DynamicUBT monitoring can effecitively reflect core temperature in heart surgery, especially during the temperature rapid decrease phase and rewarming phase for the open cardiac operation of extracorporeal circulation, it is important to guide body temperature nursing in clinical.