KAI1 is a recently identified metastasis suppressor gene located at human chromosome 11 p11.2. KAI1 protein is a member of the structurally distinct family of cell surface glycoprotein and belongs to transmembrane 4 protein superfamily. KAI1 expression is down-regulated in many metastatic tumor cells. Down-regulation of KAI1 expression also plays an important role in the genesis and development of gynecological tumor.

Objective: To build a relationship model of perceived academic self-efficacy, learning stress, and learning burnout of high school students. Methods: 674 high school students were surveyed with Learning Stress Scale of High School Students, The Perceived Academic Self -efficacy Scale, Scale of Learning Burnout of High School Students. Results: Learning stress had a direct effect on a low level of learning efficacy, perceived alienation to teacher and physical exhaustion (The direct effect value were -0.22,0.12,0.27). At the same time, perceived basic ability and perceived control partially mediated the impact of learning stress on the low level of learning efficacy, perceived alienation to teacher and physical exhaustion (the mediated effect value were -0.155 and-0.264, 0.066 and 0.299, 0.089 and 0.233). Perceived basic ability and perceived control fully mediated the relationship between learning stress and emotional exhaustion (the mediated effect value were 0.033 and 0.387). Conclusion: The students with a higher level of stress reported suffering more learning burnout than those with a lower level of stress, and vice versa.

Objective To evaluate the infection of high-risk human papillomavirus (HPV) and the expression of tumor metastasis suppressor protein KAI1 in cervical cancer.Methods The expression of KAH,HPV16/18E6 and HPV16E7 proteins were analyzed by immunohistochemistry SP assay in 117 cases of paraffin-embedded cervical tissue,including 20 normal cerival tissue as control,58 intraepithelial neoplasia (CIN) and 39 cervical cancer.Results In normal cervical tissue,CIN and cervical cancer,the positive rate of KAI1 protein were respectively 90.0 ％ (18/20),72.4 ％ (42/58),25.6 ％ (10/39).There was significant differience among three gruop (P ＜ 0.01).The positive rate of HPV16/18E6 and HPV16E7 proteins were respectively 0 (0/20),31.0 ％ (18/58),41.0 ％ (16/39); 0 (0/20),34.5 ％ (20/58),64.1％ (25/39).There were significant differience among three gruops (P ＜ 0.01).There was no correlation between the expression of KAI1 and the infection of HPV (P =0.429).Expression of KAI1 was correlated to grade of differentiation,clinical stage and lymph node metastasis (P ＜ 0.05),but was not correlated to age (P ＞ 0.05).HPV infection was not correlated to the age,clinical stage,cell differentiation and lymph node metastasis (P ＞ 0.05).Conclusion The expression of KAI1 protein is down-regulated in cervical cancer,which is not associated with the infection of HPV.

Objective To study the effects of glimepiride and short-term intensive therapy with insulin on plasma glucose and beta-cell function in newly diagnosed type 2 diabetic patients.Methods 80 newly diagnosed type 2 diabetic patients were divided into two groups of 40 patients each and randomly treated with insulin or glimepiride plus metformin for 8 weeks.The FBG,2hPBG,HbA_1c,improvement of beta-cell function were measured before and after intensive therapy in each group.Results After the treatment,FBG,2hPBG,HbA_1c were significantly decreased (all P<0.001) in each group;FCP and 2hPCP were increased(P<0.05)in each group.Conclusion Glimepiride or short-term intensive therapy with insulin plus metformin could effectively improve glycemic control and beta-cell function in newly diagnosed type 2 diabetic patients.

Objective To evaluate the clinical efficacy of Jianpi pill in the treatment of leucocytopenia induced by anti -thyroid drug.Methods According to the digital table,195 Graves hyperthyroidism patients with leucocytopenia induced by anti -thyroid drug were randomly divided into the observation group(100 cases)and the control group(95 cases).The observation group was given Jianpi pill treatment,while the control group adopted the combination therapy of batilol tablets,leucogen tablets,vitamin B4 tablets.The facial color,whether or not limb weak-ness,whether or not palpitations after strenuous exercise in the two groups were observed.The number of white blood cells and the number of neutrophils in the two groups were observed.3 months later,the curative effect of the two groups was determined according to the degree of cure.Results The total effective rates of the control group and the observation group were 52.63% and 85.00% respectively,the difference was statistically significant between the two groups(χ2 =23.96,P <0.01 ).The disappear infection rates of the control group and the observation group were 25.00% and 69.05% respectively,the difference was statistically significant between the two groups (χ2 =15.93, P <0.01 ).The total effective rates of mild,moderate,severe leucocytopenia were 95.56%,87.50%,46.67%respectively,the difference was statistically significant between mild and severe leucocytopenia (χ2 =16.00,P <0.01),and the difference was statistically significant between moderate and severe leucocytopenia(χ2 =7.94,P <0.01).The excellence rates of mild,moderate,severe leucocytopenia were 48.89%,40.00% and 48.89% respec-tively,the difference was statistically significant between mild and severe leucocytopenia(χ2 =5.92,P <0.01),and the difference was not statistically significant between moderate and severe leucocytopenia(χ2 =2.41,P >0.05).The incidence rates of dry mouth,hyperactive bowel sounds and liver damage,constipation and diarrhea in the control group were 4.21%,2.10% and 1.05% respectively,and the incidence rates of dry mouth,hyperactive bowel sounds and liver damage in the observation group were 3.00% and 1.00% respectively,there was no significant difference in adverse reactions between the two groups(P >0.05).Conclusion The curative effect of Jianpi pill in the treatment of Graves hyperthyroidism patients with leucocytopenia induced by anti -thyroid drug is sure,and it is superior to the combination therapy of batilol tablets,leucogen tablets,vitamin B4 tablets.

OBJECTIVE:To evaluate the clinical efficacy of Xuebijing injection in treating acute paraquat poisoning.METHODS:35 patients with acute severe parquat poisoning who were admitted into ICU of our hospital from Jan.2002 to Apr.2008 were enrolled in our study:15 cases were assigned to control group,20(treatment group)received Xuebijing 100 mL bid for 7～10 d in addition to the therapy as in control group.RESULTS:Liver enzyme and creatinine levels in both group were reduced,with the level in the treatment group significantly lower than in control group(P

To achieve the goal of continuous improvement, measures of multi-link management were adopted for antimicrobial use, including establishing and improving organizational frameworks and rules and regulations, conducting various forms of training for all workers and staff, formulating criteria that were based on the frontier theories and could be easily applied, taking effective measures of intervention, using scientific evaluation methods, and getting timely feedback. The measures have proved to be effective in practice.

Objective:To study the characteristics and mechanisms of language disorders in predominant periventricular lesion.Methods: 40 Patients with periventricular infarction were assessed on the Aphasia Battery in Chinese (ABC), results were analyzed to determine the relationship between neuroiconography and speech function. Results: lesion of anterial lateral ventricle led to acute mutism, limited spontaneous speech, and disorder of speech initiation. Lesion near medial lateral paraventricle led to aphemia. All these lesions are usually associated with stuttering. Conclusion: The white matter anteromedial lateral paraventricular is an important part in the automatic processes that involved in speech production. Different lesions of these regions may result in different language disorders.

Brain Computer Interface(BCI) is a direct information communication and control channel established between human and computer or other electronics devices and it is a wholly new communication system that does not depend on the brain's normal output pathways of peripheral nerves and muscles.The general constitutions and principles of BCI systems are introduced.In addition,research methods based on electroencephalograph are discussed and the existing problems and future trends of BCI are pointed out.

OBJECTIVE：To study the effects of Gushikangfuwan on osteoporosis caused by retinoic acid in rats. METHODS:The osteoporosis was induced by retinoic acid(70mg.kg-1,ig)daily in rats for two weeks. The pharmacologic effects of Gushikangfuvan was observed. RESULTS: Compared with the retinoic acid group Gushikangfuwan (6g.kg-1)enhanced the relative bone volume,average bone trabecula and bone Lacuna length in rats.Gushikangfuwan (3g.kg-1,6g.kg-1) also enhanced the content of calcium and phosphorus of thigh bone. CONCLUSIONS：Gushikangfuwan may ameliorate the bone quality and enhance the bone density in rats.