1.A Research on SQL Server Association Rules in Data Mining forZhizichi Decoction Analogous Prescriptions
Jingxian ZHU ; Qianmin SU ; Dexing CHEN ; Jinglei GUO ; Xiaoping WEN
Chinese Journal of Information on Traditional Chinese Medicine 2015;(1):43-46
Objective To discuss the specific role of association rules in the compatibility of herbs and the relationship between herbs and symptoms by analyzing ancient analogous prescriptions Zhizichi Decoction with SQL Server software.Methods The prescriptions which contain Gardenia and Semen Sojae Preparatum were searched in the database of “Ancient Prescriptions for Epidemic Disease”, and they were imported to software with the standardized data of their symptoms and ingredients, then the proper association rules were found. The laws between parameter setting and rule generation were searched through parameter adjustment.Results Many laws of the drug compatibility and relationship between herbs and symptoms were obtained effectively in data mining by adjusting the parameters:The support setting was good for finding common used drug compatibility, and the confidence was good for finding specific drug compatibility and relationship between herbs and symptoms;the item set which had high frequency, sometimes made the rule’s importance low.Conclusion The laws of compatibility of herbs and the relationship between herbs and symptoms for data mining of analogous prescriptions are discovered by analyzing the support, confidence and importance of the association-rules and the clinical magnificence between symptoms and herbs.
2.An epidemiological investigation on the cases of Shanghai pre-hospital care in 2007
Rongfeng GUO ; Zaiqian CHE ; Jinglei LI ; Xiaoguang LI ; Weijun ZHOU ; Huiqiu SHENG ; Yanyan SONG ; Weijun WU ; Erzhen CHEN ; Yiming LU
Chinese Journal of Emergency Medicine 2008;17(11):1127-1130
Objective To analyze the epidemiologieal characteristics of the pre-hospital care cases in Shanghai in the year 2007. Method Based the demographic records in the year 2007, the cases which from the database of Shanghai pre-hospital care center with full items were analyzed. Chi-square test and exact probabilities were used to compete the consfituent ratio; and the method of circular distribution was used to calculate the peak time, date and month. Results There were 86 815 patients with pre-hospital care well documented from the ur-ban districts of Shanghai. The ratio of male to female was 3.89: 1. The senile patients accounted for 84.95% of all the pre-hospital care ones. The major causes of disease in patients with pre-hospital care were trauma, eere-brovascular disease,cardiac diseases, coma, high fever, tumor emergency, acute abodomen emergency,OB/GYN emergency and upper G1 tract bleeding in turn. During the daytime, the occurrence of those emergency patients with pre-hospital care usually peaked at 2:15 o' clock with the high frequency in the period of 5:45 to 17:45 o' clock.The top nine diseases had their own peak time and high frequency period, respectively. Within a year, no peak date occurrence of patients with prehospital care, in tolal, was found. Howerer, the occurrence of patients with high fever, acute abdomen and upper GI bleeding had specific peak dates within a year, respectively. Conclusioes The pre-hospital care eases in the urban of Shanghai have own epidemiologieal characteristics. Perfect the construc-tion of pre-hospital emergency care system, improving the professional training, and thereby meeting the require-ments are factors in the fundamental guarantee of improving the rescue full success rate of severe patients.
3.Analysis of CT and MRI signs of hepatic eosinophilic infiltration
Baoliang GUO ; Fusheng OUYANG ; Bin ZHANG ; Yuhao DONG ; Zhouyang LIAN ; Xiaoning LUO ; Jinglei LI ; Changhong LIANG ; Shuixing ZHANG
Chinese Journal of Radiology 2017;51(2):132-135
Objective To study and analyze the CT and MRI findings of hepatic eosinophilic infiltration. Methods Twenty nine patients of hepatic eosinophilic infiltration who were confirmed by biopsy or clinical diagnosis were retrospectively analyzed. All the patients underwent CT and/or MRI scan. Twenty seven cases underwent upper abdominal CT plain scan and three phase enhanced scan, and 5 cases underwent upper abdominal MR plain scan and three phase enhanced scan, of which 3 cases underwent CT and MRI scan. Evaluations were made regarding to the numbers of lesion, distribution, size, shape, margin, density or signal characteristic, enhancement parttern and other special features. Pearson correlation analysis was used to analyze the correlation between the number of hepatic lesions and the number of eosinophils in peripheral blood. Results A total of 108 lesions of eosinophilic hepatic infiltration were observed in 29 cases, including 2 cases with single lesion and 27 cases with multiple lesions. Ninety five of the lesions were located in subcapsular parenchyma or surrounding the portal vein. Most subcapsular lesions were wedge-shaped(n=28). Lesions surrounding portal vein were round-shaped(n=32), while the hepatic parenchymal lesions were irregular or round-shaped(n=13). The mean size of lesion was 34 mm, ranging from 3 to 61 mm. The margin of all the lesions were obscure. The lesions showed slightly low density or isodensity on CT pre-contrast images. On MR pre-contrast images, lesions showed slightly low signal or isointense on T1WI, and hyperintense on T2WI. Branches of portal vein were found infilrated by all lesions. Tueleve cases showed“stripe sign”along the portal vein branches, 16 cases showed“halo ring sign”around the portal vein. Pearson analysis indicated a significant correlation between the number of eosinophilic hepatic infiltrated lesions and the increase of eosinophils in peripheral blood (r=0.783, P<0.05). Conclusion The imaging features of EHI had certain characteristics, especially in the three phase dynamic enhanced scanning, from which we can mainly find“progressive enhancement”,“portal vein sign”,“stripe sign”and“halo ring sign”.
4.Exploration on the practice of ideological and political teaching in curriculum of Traditional Chinese Medicine universities—taking Formulas of Chinese Medicine as an example
Jinglei GUO ; Zhiqiang ZHANG ; Xiaoping WEN
Chinese Journal of Medical Education Research 2020;19(7):793-797
The National Conference on Ideological and Political Work in Colleges and Universities puts forward that "all courses have the function of moral education", and required "to integrate ideological guidance and values shaping into the teaching of each course". Based on the practice of ideological and political teaching in the course of Formulas of Chinese Medicine in Shanghai University of Traditional Chinese Medicine, this paper summarizes eight effective integrations of professional courses and ideological education from four aspects of teaching design, teaching implementation, teaching evaluation and teaching staff. in order that this study can provide empirical research support for the organic combination of professional courses and ideological education, and also provide a useful reference for all kinds of professional courses in colleges and universities to implement the "moral education".
5.Research progress of hypoxia signal pathway in renal cell carcinoma
Jinglei ZANG ; Kangxiao GUO ; Sisheng XU ; Tao CHEN ; Xiaomei WEI
Journal of Chinese Physician 2022;24(12):1905-1908
Hypoxia is an important basic feature of the solid tumor microenvironment. With the deepening of the research on the pathogenesis of renal cell carcinoma (RCC), the expression and function of hypoxia and hypoxia inducible factor (HIF) in RCC have attracted more and more attention. The hypoxia signal pathway has become a research hotspot of tumor and other diseases in recent years. This article reviews the current understanding of hypoxia signal pathway, its correlation with the occurrence and development of RCC, and the application prospect of HIF inhibitors, in order to guide the precise treatment of clinical RCC.