Intravenous immunoglobulin(IVIG) has been increasingly used in autoimmune and inflammatory diseases in the past 30 years.The effect of IVIG is obvious,but its mechanism of action is unclear.This review discusses the progresses in mechanism of action of IVIG in recent years,which include the F(ab) 2 and Fc receptor-mediated mechanisms of IVIG,modulation of adhesion molecules and cytokine production.We also discuss these mechanisms with respect to the different autoimmune and inflammatory diseases for which they might be relevant.

With the neonatal intensive care techniques developing,the survival rate of preterm infants has increased markedly.However,these survival preterm infants are extremely vulnerable to develop various diseases,of which brain injury is the most important cause of the disability in preterm infants.At present,encephalopathy of prematurity,the incidence of which is rarely reported in domestic and national reports,mainly refers to white matter injury (WMI).This article reviews the different domestic and national reports about the incidence of encephalopathy of prematurity.

Objective To investigate the effect of Tomatis audio training on executive dysfunction in patients with stroke. Methods A total of 80 stroke patients from the Rehabilitation Branch,Tangshan Worker′s Hospital were enrolled prospectively. They were divided into either a music group or a control group (n = 40 in each group)according to random number table. On the basis of conventional rehabilitation training,both groups received music training. The patients of the control group received conventional music training (conventional frequency music without audio processing);the patients of the music group received Tomatis audio training. Both groups were trained at the same time,once a day for 60 -90 min,and they were trained for 2 cycles. The first cycle was 14 days and the second one was 10 days,the interval of the 2 cycles was 30 days (a total of 54 days). The Behavioral Assessment of Dys-executive Syndrome (BADS)was used to assess their executive dysfunction before and after music training. Results The 6 sub-projects of BADS in the music group after music training:the rule shift cards test,action program test,key seek test, temporal judgment test,zoo map test,modified six elements test,and total standard score (median 75 ])2. 0 (1. 2,2. 7),2. 0 (1. 0,2. 0),2. 0 (1. 0,2. 0),2. 0 (1. 0,2. 0),2. 0 (2. 0,2. 0),2. 0 (2. 0,3. 0),and 11. 0 (11. 0,12. 0),respectively). They were compared with those of the control group (1. 0[1. 0,2. 0],1. 0[1. 0,2. 0],1. 0[1. 0,2. 0],1. 0[1. 0,2. 0],1. 0[1. 0,2. 0],1. 0[1. 0,1. 0],and 8. 0[8. 0,10. 0],respectively]. There were significant differences between the 2 groups (all P < 0. 05). Conclusion Tomatis audio training may effectively improve the executive function in patients with stroke.

Objective To evaluate the susceptibilities of different testing methods of tigecycline against IRAB. Methods MIC and inhibitory zone diameters of 32 strains of IRAB for tigecyclinc were determined by different testing methods.Data were analyzed by comparing the results from each method to those produced by the reference macro broth dilution method. Results The rates of sensitivity intermediate resistance detected by macro broth dilution method , agardilution , MTS and Vitek-2 instrument , disk diffusion method were as follows , 34.375%, 65.625%, 0%, 3.125%, 81.25%, 15.625%, 75%, 25%, 0%, 78.125%, 21.875%, 0%, 3.125%, 81.25%, 15.625%. Compared with macro broth dilution method ,the key major error rate of other methods was 0% by FDA breakpoints , but the CA and EA rates were less than 90%. Conclusions Tigecycline has good activity against the IRAB, with significant difference in susceptible rate among the different methods.

Objective To evaluate the endometrium receptivity of endometriosis (EMs) infertile patients, and observe the influence of TCM treatment to endometrium receptivity and IVF-ET pregnancy outcome. Methods Fifty EMs infertile patients were randomly divided into two groups. The reatment group (30 cases) kept taking TCM for 3 month continuously before IVF-ET embryo transplantation, and the control group (20 cases) received no treatment, with 30 healthy women as normal control. Using transvaginal color doppler ultrasound to detect and compare the endometrial thickness, endometrium and endometrial blood flow distribution types, and uterine artery blood flow parameters in window transvaginal stage. Results There was no difference in endometrial thickness between the EMs infertility patients and the normal group, and the endometrial thickness also had no obvious changes before and after treatment (P>0.05). RI and PI of EMs infertility patients were significantly increased, compared the with normal control group (P<0.05). In treatment group, the persentage of type Ⅰ blood distribution was 23.33%(7/30), in control group was 25.00%(5/20), and 66.67%(20/30) in the normal group, significantly higher than that of the EMs infertility patients (P<0.01). Uterine artery blood flow parameters RI, PI value were significantly decreased after treatment in treatment group, endometrium and endometrial blood flow type Ⅰ distribution increased to 60.00%(18/30). The rate of normal pregnancy was 46.67% (14/30) in treatment group, and control group was 30.00% (6/20). Conclusion EMs may affect uterine artery hemodynamic status and endometrium receptivity. TCM treatment can improve the endometrium receptivity of EMs infertile patients and improve the success rate of IVF-ET.

ObjectiveTo explore an effective educational method of medical humanity to improve the medical humanistic quality for nursing students and to lay a basis for the culture of medical personnel with high-quality.MethodsTwo classes of nursing students in grade 2010 were selected randomly and divided into the control group ( CG,n=65 ) and the experimental group ( EG,n=62 ).Personnel training project of our school was applied in the control group including the teaching of compulsory basis medical humanity courses:medical psychology,interpersonal communication,medical ethics and laws from the first semester to the third semester after entering the school.The pervasive teaching method was used in the EG.The basic content of humanistic quality,education was integrated systematically into the teaching of every course,class and extra-curricular activity in a planned way.The check on the topic of etiquette,verbal expression and communication and psychological quality ( the full mark of each topic was 10 points ) was conducted in the third semester in the two groups.The average points of the three topics were graded as the students' final mark of this course.T-test analysis on students' mark of each subject was used.Results The result of t-test showed that the marks of etiquette and psychological quality in EG were obviously higher than those in CG ( P＜0.05 ),however,no statistic difference in speech communication and expression was observed.ConclusionThe pervasive teaching method is beneficial to students concerning the accepting,understanding,digesting and absorbing of medical humanity knowledge can it can effectively enhance the humanistic quality of medical students.

Objective To observe the effect of treating acute left heart failure with Shenmai injection and auxiliary conventional western medicine. Methods 132 patients were randomly divided into a control group and a treatment group, with 66 cases in each group. The control group was treated with lanatoside C, captopril, diuretics, and aminophylline. While the treatment group was additionally treated with Shenmai injection on the basis of the control group. Left ventricular ejection fraction(LVEF), left smothering end-diastolic diameter(LVEDD)value, the index of b-type natriuretic peptide(BNP), and 24 h dynamic electrocardiogram(ecg)were observed in both groups after 1 month’s treatment. Results LVEF and BNP were improved in both groups after the treatment[LVEF and BNP were(40.42 ± 4.32)%, (306.57 ± 201.21)pg/ml in the treatment group and(37.92±3.32)%, (451.51±294.23)pg/ml in the control group before the treatment;(35.28±4.15)%, (540.17±382.23)pg/ml in the treatment group and(35.13±2.35)%, (572.35± 422.21)pg/ml in the control group after the treatment], and the curative effect in the treatment group was better than the control group(P<0.05). LVEDD and 24 h average heart rate were also improved in both groups after the treatment [LVEDD and 24 h average heart rate were(59.81±59.81)mm, (79.62±6.38)times/min in the treatment group and(60.91±7.31)mm, (82.61±6.32)times/min in the control group before the treatment;(60.87 ± 7.75)mm, (85.03 ± 7.75)times/min in the treatment group and(61.81 ± 7.35)mm,(86.23 ± 8.35)times/min in the control group after the treatment], but there was no statistical differenc(P>0.05). Conclusion Shenmai injection has good effects in the treatment of acute left heart failure.

In total, 4006 women aged 25 -65 years at Qiaozi Town, Huairou District, Beijing were screened for cervical cancer during April to June, 2009. Results showed that 54. 52% of the women screened suffered from varied gynecological illness, highest in those aged 30 - 34 years ( 80. 90% ) and lowest in those aged 50 -54 years. The top three gynecological morbidity among them were cervicitis (34. 77% ), virginities ( 12. 88% ) and uterine leiomyoma (8. 34% ). Precancerous lesions in 12 women,endometrial cancer in one woman and cervical cancer in one woman were detected by cervical cytological examinations.

Objective To analyze the outcomes of frozen-thawed blastocyst and cleavage embryo transfer after whole embryos cryopreservation. Methods The data of 489 IVF-ET cycles in reproductive medicine center of our hospital from September 2012 to August 2013 were analyzed retrospectively. Whole embryos cryopreservation in 214 patients were carried out with vitrification method and served as group A , 275 cycles performed fresh embryo transfer were served as group B. Then group A and group B were subdivided into group A1 (83 cycles),group A2 (131 cycles), group B1 (120 cycles)and group B2 (155 cycles)according to blastocyst transfer or cleavage-stage embryo transfer. The clinical outcomes of all groups were compared each other. Results The pregnancy rate and embryo implantation rate in group A1 were significantly higher(71.1% ,53.0%)than those in group A2, B1 and B2 (A2 group: 57.3%, 34.0%, B1group: 55.0%,42.1%, B2 group: 52.9%, 32.7%,respectively)(P<0.05). The embryo implantation rate in group B1 were higher than those in group B2 (P < 0.05). Conclusion F-ET after whole embryos freezing could significantly improve the embryo utilization rate and clinical pregnancy rate. Frozen-thawed blastocyst transfer could get better clinical outcomes than frozen-thawed cleavage-stage embryo transfer.

Objective To evaluate the clinical value of frozen-thawed blastocyst transfer and the blastocyst derived from frozen-thawed cleavage stage embryo transfer.Methods The data of 5 1 8 cycles in reproductive medicine center of the hospital from Sep-tember 2012 to August 2013 were analyzed retrospectively.According to the frozen-embryos type,all patients were divided into three groups,group A:frozen-thawed blastocyst transfer,129 cycles;group B:blastocysts derived from frozen-thawed cleavage stage embryos transfer,123 cycles;group C:frozen-thawed cleavage embryos transfer,266 cycles.The clinical outcomes of all groups were compared with each other,and the rates of blastocyst formation and cancellation were compared between group A and group B.Re-sults The rates of biochemical pregnancy,clinical pregnancy and embryo implantation in group A(70.5%,61.2%,42.3%)and group B(67.5%,58.2%,40.2%)were significantly higher than group C(53.0%,42.5%,23.1%)(P<0.05);there were no signif-icant differences in the rates of early abortion,ectopic pregnancy,multiple pregnancy among three groups(P>0.05);there were no significant differences in the blastocyst formation rates of the high quality cleavage embryos at D3 in fresh cycles and the frozen-thawed cleavage embryos(62.5%vs.57.7%)(P>0.05)and those two groups were both significantly higher than the poor quality cleavage embryos at D3 in fresh cycles(20.3%)(P<0.05).Conclusion Blastocyst transfer in vitrified-thawed cycles could get rel-atively satisfactory clinical outcomes.There are higher blastocyst formation rate and better clinical outcomes of transfer blastocyst derived from frozen-thawed cleavage embryo.