Objective To investigate the clinical effect of hysteroscopy combined with foley balloon tamponade in the management of caesarean scar pregnancy ( CSP ) . Methods Twenty-one cases were diagnosed as having CSP by ultrasound examinations from January 2008 to November 2013.Among them, 11 cases with serum β-hCG below 500 IU/L underwent the surgery after taking mifepristone for 2 days, while 10 cases with serum β-hCG over 500 IU/L underwent surgery after injection of MTX combined with oral administration of mifepristone for 7 -14 days.All the cases were treated by hysteroscopy combined with foley balloon tamponade . Results The hysteroscopic operation was successfully conducted in 19 of 21 cases, with the operate time ranged 15-42 min.One case was given a second hysteroscopy and one case required a secondary laparoscopic procedure for the uterine perforation.In 18 cases with preoperative serum β-hCG below 500 IU/L, the intraoperative blood loss was 20 -100 ml, while in another 3 cases with preoperative serum β-hCG 1085-2760 IU/L, the blood loss was 200-800 ml.Follow-up examinations at clinic for 2-4 weeks in 16 cases showed levels of β-hCG declined to normal and recovery of menstruation at 43-56 postoperative days with normal menses amount . Conclusion Hysteroscopy combined with foley balloon tamponade in the management of CSP offers advantages of safety and effectiveness , which is deserved to clinical application .

Objective:To evaluate the efficacy and safety of thalidomide on preventing and treating radiation-induced oral mucositis (RIOM) in nasopharyngeal carcinoma (NPC). Methods:A total of 60 patients with NPC were randomly divided into treatment group and control group. The treatment group took thalidomide and gargled with mixture of saline+gentamycin+dexamethasone when ra-diotherapy started, and the control group gargled only with mixture of saline+gentamycin+dexamethasone. The time of occurrence and degree of RIOM in both groups were registered at the same time. Results:The incidence of RIOM in treatment group was lower than that in control group (P<0.05). For the incidence of 3 or 4 grade RIOM, the treatment group was also lower than the control group. No statistical difference in terms of objective response rate was found between the two groups (P>0.05). There was no statisti-cally significant difference between the treatment group and the control group in the oral average dose, V30, V35, V40, V45, V50, and V54 (P>0.05). There was no statistically significant difference between the treatment group and the control group in the use of nutri-tion agents, hormones and antibiotics (P>0.05). There was no statistical difference between the groups in the drowsiness, peripheral nerve toxicity, hematologic toxicity and gastrointestinal reaction (P>0.05). Conclusion:Thalidomide can reduce the incidence and se-verity of RIOM for radiotherapy of patients with NPC, which deserves clinic application.

Objective:To understand the characteristics of sexualized drug use (SDU) among men who have sex with men (MSM) in Chengdu and classify their behavioral patterns by applying the two-step cluster (TSC) algorithm and by exploring the association between SDU patterns and high risk sexual behaviors, in order to provide a reference basis for the development of HIV prevention interventions.Methods:Supported by an MSM-friendly organization in Chengdu from December 2021 to February 2022, MSM were recruited by on-site survey and peer referral to collect information on sociodemographics, SDU characteristics, sexual behaviors, STD diagnosis, and HIV status. TSC was performed to classify the characteristics of SDU, and the differences between groups were compared. Chi-square test and multiple binary logistic regressions were used to identify the relationship between SDU clusters and HIV-related risk sexual behaviors.Results:A total of 727 MSM were surveyed, and 39.8% (289/727) of the respondents reported SDU experience with a same-sex partner in the last six months. TSC clustered SDU-MSM into three behavioral pattern groups. There were significant differences in monthly income, types of drugs used for SDU, mode, frequency, polydrug use, multiple sexual partners, non-adherence to condom use, and group sex among the three groups of SDU-MSM ( P<0.05). Multivariate binary logistic regression analysis showed that the third category of SDU-MSM was 2.22 (95% CI: 1.06-4.66) times more likely than the first category not to use condoms consistently; the third and second categories were 2.82 (95% CI: 1.18-6.77) times and 8.78 (95% CI: 3.42-22.42) times. Conclusions:The prevalence of SDU among MSM in Chengdu was more than 1/3, and different SDU clustering pattern was associated with high-risk sexual behaviors. MSM with higher SDU frequency, drug use, and polydrug abuse are more difficult to adhere to condom use and more likely to have group sex and high risk sexual behaviors, increasing the risk of STD and HIV infection, and need to strengthen SDU surveillance and intervention.