Objective To study the changes of serum low density lipoprotein cholesterol (LDL-C) and clinical significance in patients with hepatocirrhosis.Methods The serum LDL-C contents in groups from 3 573 cases hepatocirrhosis and 168 cases controls were determined.The relationship between serum LDL-C and the factors of prognosis、grades of liver fuction、some complications etc.in hepatocirrhosis patients were analyzed.Results The serum LDL-C contents in hepatocirrhosis group [(1.67 ± 0.94)mmol/L] was significantly lower than that in control group (2.02 ± 0.67) mmol/L] (t =4.67,P ＜ 0.01).The serum LDL-C contents in death [(1.30 ± 1.11 mmol/L),the grade of liver function Child-pugh B [(1.74 ± 0.92) mmol/L],the grade of liver function Child-pugh C [(1.28 ± 0.97)mmol/L],complicate upper gastrointestinal bleeding[(1.33 ± 0.84)mmol/L],not complicate primary hepatic carcinoma [(1.54 ± 0.82) mmol/L] were significantly lower than that in survival [(1.73 ± 0.90) mmol/L](t =9.45,P ＜ 0.01),the grade of liver function Child-pugh A [(2.04 ± 0.76) mmol/L] (q =11.55,P ＜ 0.01),the grade of liver function Child-pugh A [(2.04 ± 0.76) mmol/L] (q =29.25,P ＜ 0.01) and B [(1.74 ± 0.92) mmol/L] (q =17.71,P ＜ 0.01),not complicate upper gastrointestinal bleeding[(1.76 ± 0.95) mmol/L] (t =11.12,P ＜ 0.01),complicate primary hepatic carcinoma groups [(1.93 ± 1.10) mmol/L] (t =12.02,P ＜ 0.01) with hepatocirrhosis,respectively.significant negative correlation was shown between serum LDL-C contents and liver function grades in patients with hepatocirrhosis (r =-0.43,P ＜ 0.01).Conclusion The serum LDL-C contents was obviously decreased in hepatocirrhosis,and it is closely correlated to the factors of prognosis,grades of liver fuction,whether complicated upper gastrointestinal bleeding and primary hepatic carcinoma,etc.