OBJECTIVE To study the quality of the related articles published in a core biomedical journal Chinese Journal of Nosocomiology in the latest five years. METHODS Statistical analysis and quality evaluation were performed based on the 2 612 related papers which selected from its 48 issues published during the period from 2000 to 2004. RESULTS(1) Five year average publication capacity index was 0.57.(2) The majority authors were from medical universities or their affiliated hospitals and provincial or military medical units.(3) The majority types of the papers were scientific research articles,theses and reviews.(4) There were 160 grant based projects.(5) The average quotations were 6.0 in each paper,among them: 68.6% were Chinese literature,31.4% were from foreign sources,while 34.2% were self-citation.(6) The average issues time lag was 273.5 days in the latest five years. CONCLUSIONS Chinese Journal of Nosocomiology has the superiority in the above aspects,which confirmed its quality as a core journal.

Objective To explore the optimization and standardization of imaging parameters for 16-slice spiral CT angiography in intracranial and cervical arteries. Methods Sixty patients were randomly divided into three groups, and the automatic bolus tracking thresholds of 100, 150 and 180 HU in the descending aorta were used respectively. The CT values of artery and vein among three groups were compared. Other 40 patients were randomly divided into A and B group and underwent CTA with different slice thickness and pitch, and the difference in arterial display were compared. Results The carotid and intracranial arteries in all three groups were well displayed. No statistical difference was found in enhancement CT values of three points of common carotid artery and internal carotid artery among three groups (P>0.05), while the differences of CT values in same level vein among three groups were significant (P<0.05). There was no significant difference in the average score of display degree between group A and B. Conclusion Imaging parameters for 16-slice spiral CT angiography in intracranial and cervical arteries are recommended as follows:100 HU (threshold), 120 kV, 280 mA, 1.25 mm (thickness), 1.375:1 (pitch), 0.5 s/r and 16×0.625 mm (effective thickness).

Objective To evaluate color Doppler ultrasonography(CDU) in the diagnosis of intraocular tumor. Methods Two hundred seventy-three cases(301 eye) of intraocular space-occupying lesions were examinated by high-resolution CDU to observe the two-dimensional gray-scale image and vasculature of intraocular tumors. Results Intratumor calcifying spot could be detected in 138 cases(149 eye) of 153 cases(178 eye) with retinoblastoma,and intratumor blood flow with branchy pattern could be found in 152(177 eye) of 153 cases(178 eye) with retinoblastoma. In 4 Coats disease and 2 persistent hyperplastic primary vitreous and 3 retinopathy of prematurity, intratumor calcifying spot couldn′t be detected,and the band blood flow of the detached retinal vessels could be detected. Intratumor blood flow with branchy pattern could be detected in all 66 choroidal melanomas and 4 melanomas of ciliary body with infiltrated choroid and 15 of 19 choroidal metastases. Intratumor blood flow with “simulating vessel pool” or conglomerate sparkled pattern could be found in 12 choroidal hemangioma. No intrinsic flow was detected in 8 choroidal hemorrhages or subretinal hemorrhages and 2 teratoid medulloepitheliomas. Conclusions CDU is of significance in the diagnosis and differention of intraocular tumors.

Objective To understand the status of mycoplasma infection and drug susceptibility to provide reference basis for clinical rational drug use.Methods The reagents kits produced by Shanghai Aopu Biopharmaceutical Co.,Ltd.were adopted to per-form the mycoplasma culture,identification and susceptibility test.Results Among 1 745 specimens,896 cases of mycoplasma in-fection were detected with the total detection rate of 51 .35%,including Ureaplasma urealyticum (Uu)infection in 841 cases (48.19% ),Uu combined Mycoplasma hominis(Mh)infection in 92 cases(5.27% )and Mh infection in 17 cases(0.97%).The de-tection rate was 9.46% in males and 41 .89% in females,the infection rate in females was obviously higher than that of males.The results of drug susceptibility test showed that the sensitive rate to doxycycline,josamycin and minocycline was higher than 95%, while the resistant rate to norfloxacin and lincomycin was higher than 75%.Conclusion Mycoplasma infection in this hospital is dominated by Uu.Doxycycline,josamycin and minocycline can be used as the empirical medication to treat mycoplasma infections in this hospital.But before clinical treatment,the mycoplasma culture and the drug susceptibility test should be performed as possible for rational and standardized medication.

Objective To evaluate the feasibility and safety of transabdominal ultrasound-guided suction curettage to treat cesarean scar pregnancy (CSP) and investigate factors affecting prognosis of CSP. Methods This was a retrospective case study of 43 cases who were diagnosed as CSP and treated by suction curettage under transabdominal ultrasound guidance as an initial treatment of CSP in Obstetrics and Gynecology Hospital of Fudan University over past 7 years (from 2007 to 2013);factors affecting prognosis of CSP were investigated. Results 39 of the 43 cases (91%) were successfully treated. There were no statistically significant differences in maternal age, gravidity, abortion frequency, and the time interval between current CSP and last cesarean delivery, the myometrium thickness between the gestational sac and the bladder wall between the success group and the failure group (all P>0.05). Statistically significant difference was found in crown-rump length (CRL) between the two group (median of the two group was 18.5, 2.0 mm) by rank sum test (P=0.047). Univariate logistic regression analysis demonstrated that CRL was strongly associated with the prognosis and the OR for no complications was 18.50, comparing CRL≤6 mm versus CRL>6 mm (P=0.020). Conclusion Transabdominal ultrasound-guided suction curettage is effective and safe in the treatment of CSP with CRL≤6 mm.

Objective To investigate the changes of the expression of HSP90? in the liver of severely scalded rats at the early stage of stress Methods The expression levels of HSP90? in the liver of rats at different time points after severe scald were detected by Western blotting and then the expression of HSP90? in the nucleuses was observed by immunohistochemistry Results The expression of HSP90? significantly increased in the liver of rats after severe scald, especially during 12～48 h Abnormal high expression of HSP90? in the nucleuses around was found at 48 h after scald Conclusion The abnormal high expression of HSP90? due to severe scald may be one of the important causes resulting in the disorder of glucocorticoid receptor at the early stage of stress after severe trauma.

Objective To explore the feasibility of reducing radiation dose and iodine contrast medium in 70 kVp abdominal CTA imaging in low-body mass index (BMI;≤22 kg/m2) patients.Methods The 48 patients with suspected abdominal vascular diseases and low BMI (≤22 kg/m2) underwent abdominal CTA.All patients were divided into two groups according to tube voltage and contrast intake randomly.The parameters of group A (n=27) were contrast intake 300 mgI/kg,70 kVp,the conditions of group B (n=21) were contrast intake 500 mgI/kg,120 kVp,and the other conditions were the same in both groups.The image quality of right renal arterial images was evaluated by two observers simultaneously (5-scale).The consistency and difference between the two observers were analyzed.The CT values of abdominal aorta,celiac trunk,superior mesenteric artery,common hepatic artery,pancreatic artery and erector spinae,SD values of erector spinae on the level of right renal hilus were measured respectively in both groups.The CT values of abdominal aorta and its main branches,the CNR of abdominal aorta,the volume CT dose index (CTDIvol),dose-length product (DLP) and overall iodine intake in each group were compared.Results The scoring of right renal arterial images in both groups were 5.00 (1.00),the results showed a good consistency (Kappa=0.932,0.911).The CT values of abdominal aorta,superior mesenteric artery,common hepatic artery and pancreatic artery in group A were all more than those of in group B (all P＜0.05).The CNR of group A was higher than that of group B (P＜0.05).The CTDIvoland DLP in group A decreased by 73.36％ and 74.41％ compared with group B.The overall iodine intakes in group A and group B were (46.33±6.43)ml and (84.31±10.71)rnl,respectively.The overall iodine intake of group A decreased by 45.05％ compared with group B.Conclusion For patients with low BMI (≤22 kg/m2),a 70 kVp tube current abdominal CTA scanning can significantly increase the contrast of images of abdominal artery and its branches.Meanwhile,the radiation dose and overall iodine intake can obviously decrease.

Purpose To explore the influence of duration of scan acquisition on perfusion parameters in whole renal perfusion with Revolution CT.Materials and Methods Fortytwo patients without pathologic changes in bilateral kidneys were divided into group A (with short perfusion time) and group B (with long perfusion time) according to the duration time of the perfusion scan.The Revolution CT axial scan mode was used for perfusion scan,and the width of detector was 16 cm.The perfusion CT series were performed in 50 seconds,each comprising 25 volumes with identical parameters (80 kVp,200 mA) in group A.The perfusion CT series were performed in 594 seconds,each comprising 23 volumes with identical parameters (120 kVp,55 mA) in group B.The source datasets were post-processed with CT Perfusion 4D software,and the perfusion parameter maps were obtained when right renal abdominal aorta was taken as entry artery.Perfusion parameters of bilateral kidneys were compared within and between group A and group B,respectively.CT dosage index of volume (CTDIvol) and dose length product (DLP) were recorded.The effective dose (ED) was calculated and compared.Results There were no statistical difference in all parameters between bilateral kidneys within each group (P＞0.05).However,blood volume,time to peak,and permeability surface in the cortex and medulla of bilateral kidneys all showed differences between the above two groups (P＜0.05).The mean transit time in the medulla between the two groups was different (P＜0.05),but neither the blood flow in the medulla and cortex nor the mean transit time of the cortex had difference between the two groups (P＞0.05).The effective radiation doses were (23.10± 4.39)mSv in group A and (23.19±0.00) mSv in group B,respectively (without statistic difference:P＞0.05).Conclusion CT perfusion parameters with different duration time show differences in whole renal perfusion;therefore,scanning time needs to be set according to the clinical application.

Purpose To investigate the effect of low contrast dose and low tube voltage combined with adaptive statistical iterative reconstruction (ASIR) on image quality of abdominal CT angiography. Materials and Methods 139 patients with body mass index (BMI) <22 kg/m2 who were supposed to undergo abdominal dynamic contrast-enhanced examination were prospectively enrolled and randomly divided into group A with 78 cases (80 kVp tube voltage +50% ASIR, contrast agent concentration 270 mgI/ml) and group B with 61 cases (120 kVp tube voltage, contrast agent concentration 350 mgI/ml). Subjective score of right renal artery image quality of the two groups were evaluated and the coefficient between them was tested; CT dose index of volume (CTDIvol), CT values of abdominal aorta and its branches, and the right side erector spinae, contrast-to-noise ratio (CNR) of the vessel, the right erector spinae image noise (SD), and the total amount of iodine were also compared between the two groups. Results The inter observer agreement for subjective scores were very good (Kappa value>0.80) in both groups, the subjective score of group A and group B were 4.60±0.51 and 3.81±0.76, respectively, and the difference was statistically significant (Z= - 6.86, P<0.05). CTDIvol of group A and group B were (5.56±4.21) mGy and (7.11±1.54) mGy, respectively, the difference was statistically significant (t= - 9.89, P<0.01); CT values of the arteries in both groups were all greater than 400 HU; CT values and the CNR of the abdominal aortic trunk and branches in group A were higher than those of group B (P<0.05); there was no statistically significant difference of image noise between the two groups (P>0.05). The total amount of iodine dose in group A and group B was 270 mg and 350 mg respectively, with a 22.86% reduce of the total iodine for each patient in A group than in B group. Conclusion For patients with BMI<22 kg/m2, it is feasible to use low dose contrast medium with low tube voltage and ASIR, which may not only improve the image quality of abdominal CTA but also reduce the radiation dose and iodine content.

PurposeTo investigate the effects of the low concentration contrast medium combined with optimal single source spectral imaging on displaying feeding arteries of gastrointestinal tract malignant tumors.Materials and Methods Seventy-one patients of body mass index (BMI) >25 kg/m2 with gastrointestinal tract malignant tumors were prospectively studied. All the cases were randomly divided into two groups: high concentration group (33 cases with high concentration contrast medium of 350 mgI/ml in routine scan) and low concentration group (38 cases with low concentration contrast medium of 270 mgI/ml in optimal single source spectral imaging). The optimal single source images were generated automatically. The subjective image scores, CT value of the tumor feeding arteries, image noise, contrast-to-noise ratio (CNR) and CT dose index of volume (CTDIvol) of optimal single source spectral images in two groups were compared. Results The optimal single source of low concentration group were 51-60 keV. The subjective image score of low concentration group was higher than high concentration group (Z=-4.280,P<0.01). The consistency between the two investigators was good (Kappa=0.824 and 0.843,P<0.05). The consistency between the two investigators in evaluating CT value of the tumor feeding arteries, CT value at the right erector spinal muscle, image noise and CNR data was good (ICChigh concentration group=0.998, 0.968, 0.959 and 0.990; ICClow concentration group=0.988, 0.981, 0.969 and 0.937). The CT values of the tumor feeding arteries and CNR of the low concentration group were higher than that of the high concentration group, but the image noise was lower than that of high concentration group (t=-14.937, 4.263 and-17.264,P<0.01). There was no statistical difference of CTDIvol between the two groups (t=1.278,P>0.05).Conclusion The low concentration contrast medium with optimal single source spectral imaging in patients with large BMI may improve CTA image quality of feeding arteries of gastrointestinal tract malignant tumors without increasing radiation dose.