0.05). CONCLUSION: Cefepime is a safe and effective agent in treatment of low-respiratory tract infection like ceftazidme.

OBJECTIVE To investigate the efficacy of rneropenem for the meatment of the patients with serious community-acquired pneumonia(SCAP).METHODS Sixty-four patients with SCAP were randomly divided into two groups.Group A(the treatment group,41 cases) was treated with meropenem(5-1.0 g iv q8-12 h?7 d) and group B(the control group,23 cases) treated with mezlocillin(5-1.0 g iv q8-12 h?7 d) in an open clinical study.RESULTS The efficacy rate of group A was 85.0%,with a bacteria elimination rate of 86.4% wheveas 57.0% and 64.3% in group B.There were significant difference between two groups(P

Cholangiocarcinoma (CCA) is a group of solid tumors with high malignant degree and poor prognosis. Surgical resection has still been the main therapy options. Targeting therapy and immunotherapy are the main anti-tumor methods that have been paid more and more attention in recent years, especially immunotherapy. The tumor microenvironment of CCA is complex, which encompasses not only interstitial and endothelial cells, but also a large number of immune cells. In addition, the innate and adaptive immune systems also play a role. This article summarizes the immune-related studies of cholangiocarcinoma and the latest clinical trials of immunotherapy.

Objective To understand the basic situation and existing problems of cost accounting information construction in the traditional Chinese medicine hospital. Methods We made a cross-sectional study of all traditional Chinese medicine hospitals cost accounting informatization, and then analyzed the results. Results In the survey of 1588 traditional Chinese medicine hospitals, there exists the problem with 78.65%for limited software;57.43%for not sharing between the systems;43.20%for outdated software. The occupancy rate was 81.86%for HIS system, 87.09%for the accounting software, 39.11%for cost accounting software, 5.42%for none. The proportion of hospitals was over 95% whose income data statistics to department;80% for spending data;73.05%for fixed assets depreciation cost;51.39%for amortization of intangible assets and 52.77%for medical risk fund. The proportion of hospitals was 81.49%whose data inside services statistics to medical auxiliary departments and higher than the logistics department, which was 63.85%.Conclusion The occupancy rate of cost accounting system software was limited in traditional Chinese medicine hospitals. The problems were limited cost accounting system software and unavailable information shared between the systems.

0.05). While in D_2 and D_1+D_2 groups, the AI (0.54?0.05,0.64?0.04,0.63?0.04,0.65?0.11, 0.67?0.07) were increased, and the latter was more obviously. There were significant differences compared with sham-irradiated group(P

Objective To investigate collagen metabolism modulation of Intermedin 1-53 ( IMD1-53 ) on angiotensin Ⅱ( AngⅡ)-induced rat cardiac fibroblasts .Methods SD neonatal rat cardiac fibroblasts were cultured and divided them into control group, AngⅡ +different concentrations IMD1-53 groups.ⅠandⅢcollagen expression in cardiac fibroblasts were measured by Westem blot , IMD1-53 receptor-like receptor ( calcitonin receptor-like receptor , CRLR) and transforming growth factor-β( TGF-β) mRNA expression were exammed by real-time PCR.Results IMD1-53 significantly inhibited AngⅡ-induced collagen synthesis in cardiac fibroblasts , and this effect was more ob-vious with the increase of IMD 1-53 ( P<0.01 ,P<0.05 ) .Similar phenomenon was recorded in TGF-βexpression in cardiac fibroblasts ( P<0.05 ) .Conclusions IMD1-53 inhibited collagen synthetic in cardiac fibrosis induced by AngⅡ, down-regulated TGF-βexpression.These may relate to IMD1-53 anti myocardial fibrosis.

The postganglionic fibers arising from sympathetic nervous system dominate some activities in human body,such as secretion of sweat glands,vasoconstriction and pain transmission.While block its transmission can treat some certain diseases.Now sympathectomy is mainly applied in treating primary hyperhidrosis,peripheral artery disease (thromboangiitis obliteran,Raynaud's diseases),long Q-T syndrome,and intractable abdominal pain,and video-assisted surgery is the mainstream.Basing on the ensurement of efficacy,reasonable extension of resection range can reduce the incidence of compensatory hyperhidrosis.Primary hyperhidrosis,which applying widely,is the best indication for this sympathectomy.For peripheral artery disease (thromboangiitis obliteran,Raynaud' s diseases),long Q-T syndmme,and intractable abdominal pain,sympathectomy should be taken into consideration when drug treatment fails or taboos.Sympathectomy will become more minimally invasive as well as improve living quality for patients in the future.

Machine learning technology is more and more widely used in the medical field. Biliary tumor is a tumor originating from the biliary system with a very high degree of malignancy. Machine learning technology has been applied in the field of biliary malignancy to assist physicians in disease diagnosis and provide valuable prognostic prediction and early screening recommendations. This paper summarizes the research progress of machine learning in the field of biliary tract tumors in recent years, and provides references for the auxiliary diagnosis, early screening prediction and postoperative survival prediction of biliary tract tumors.

Cholangiocarcinoma is a highly malignant disease with low surgical resection rate. It’s resistant to chemoradiotherapy and the prognosis of cholangiocarcinoma is poor. Although immune checkpoint inhibitors (ICIs) have achieved great success in tumor therapy in recent years, patients with cholangiocarcinoma have a poor response to immunotherapy, because of the complexity and diversity of immune microenvironment. Therefore, understanding the composition and characteristics of the immune microenvironment of cholangiocarcinoma, regulating targets in immune microenvironment, and adopting ICIs combined therapy, is important for immunotherapy for cholangiocarcinoma.

Gallbladder cancer is a high malignancy which is predisposed to invade adjacent organs and have lymph node metastasis. Gallbladder cancer is not sensitive to radiotherapy or chemotherapy with the worst prognosis among biliary tract cancers. At present, radical resection is the only possible method to cure gallbladder cancer. However, there are still many controversies about the surgical strategies, the extent of liver resection and lymph node dissection, and the treatment of incidental gallbladder cancer. In addition, under the background of the great success of immunotherapy and targeted therapy in a variety of solid tumors, it is also a question worthy of further considerations that whether the status of surgery in the treatment of advanced gallbladder cancer will be changed in the near future.