Objective To discuss the application of glauber's salt external impact on cytokines in patients with celiac inflammation and clinical application value.Methods Clinical data of 180 patients with acute pancreatitis were retrospectively analyzed.According to the different treatment,they were divided into the observation group and control group,the control group were treated by routine western medicine,the observation group were treated with mirabilite topical therapy,records of two groups of patients with clinical therapeutic effect.Results The total effective rate of the observation group was 92.22%,which of the control group was 82.22%.The differences between the two groups was statistically significant (χ2 =4.037,P <0.05).The cytokines concentrations of the observation group after treatment were as follows:TNF alpha (40.02 ±5.19)ng/L,IL -6 (32.93 ±7.65)ng/L,IL -8 (23.41 ±3.86)ng/L, NF -κB (85.36 ±19.65)U /L;those in the control group after treatment:TNF alpha (63.38 ±8.97)ng/L,IL -6 (56.73 ±11.16)ng/L,IL -8 (40.85 ±7.43)ng/L,NF -κB (231.32 ±41.28)U /L,statistical analysis showed that contrast differences among groups with statistical significance (t =21.384,16.687,19.760,16.687,all P <0.05).The observation group (3.18 ±1.33)d abdominal distension relief time,gastrointestinal function recovery time (5.64 ±1.86)d,length of hospital stay (15.13 ±3.76)d;The control group (5.64 ±2.31)d abdominal distension relief time,gastrointestinal function recovery time (8.96 ±3.45)d,length of hospital stay (24.59 ±5.87)d;Statisti-cal analysis showed that contrast differences among groups with statistical significance(t =8.755,8.035,12.874,all P <0.05).Conclusion Using glauber's salt topical application in patients with celiac inflammation can effectively reduce inflammation in the body,improve the treatment effect,to speed up the patients with gastrointestinal functional recovery,which is worth popularization and application in clinic.

Objective To discuss the effects on sexual function and quality of life by application of inguinal hernia without tension repair surgery in male patients,and the value of clinical application.Methods 1 10 cases of inguinal hernia patients were randomly divided into 2 groups,with each group of 55 cases.The control group was given conventional surgery,the observation group was conducted with inguinal hernia without tension repair surgery,clinical therapeutic effects of two groups were recorded.Results Testicular volume of the observation group 3 months after operation was (10.21 ±2.61)cm3,testicular artery biggest blood flow velocity was (3.38 ±1.21)cm/s.Testicular volume of the control group 3 months after operation was (10.14 ±2.63)cm3,testicular artery biggest blood flow velocity was (3.36 ±1.23)cm/s,the differences between the two groups had no statistical significance (t=0.1401, 0.0860,all P>0.05).The observation group had physiological function score of (76.64 ±6.29),physiological role score of (57.86 ±5.97),body pain score of (79.27 ±7.88)points,overall health score of (78.85 ±7.11mm), energy score of (64.35 ±5.63)points,social function score of (56.64 ±5.89)points,emotional functions score of (68.56 ±6.64)points and mental health score of (72.75 ±6.82)points.The control group had physiological function score of (70.03 ±3.78)points,physiological role score of (47.13 ±3.66),body pain score of (71.09 ± 5.14)points,overall health score of (69.93 ±5.05mm),energy score of (57.81 ±3.25)points,social function score of (50.33 ±4.14)points,emotional functions score of (60.76 ±5.15)points and mental health score of (65.22 ± 4.09)points,the differences between the two groups were statistically significant (t=6.680 1,11.363 7,6.448 1, 7.585 5,7.461 0,6.500 0,6.883 9,7.022 3,all P<0.05).Conclusion Application of inguinal hernia without tension repair surgery in male patients has mild effect on sexual function,it could improve patients quality of life,but the long-term effects remain to be further observed and summarized.

Objective To explore the efficacy and safety of low-dose tirofiban in stent-assisted coil embolization(SAC)for ruptured intracranial aneurysms.Methods From April 2011 to September 2020,335 patients of ruptured intracranial aneurysms with subarachnoid hemorrhage(SAH)admitted in the First People's Hospital of Changzhou were retrospectively analyzed.All cases underwent stent-assisted coil embolization within 24-48 h and antiplatelet medications.The patients were divided into dual antibody group(89 cases)and tirofiban group(246 cases).Baseline and clinical data of all patients were collected for comparison between groups,including age,sex,hypertension,diabetes mellitus,Hunt-Hess grade at admission,modified Fisher scale score at admission,aneurysm diameter(＞5 mm,≤5 mm),aneurysm location(anterior circulation,posterior circulation),postoperative acute hydrocephalus or intraventricular hemorrhage,postoperative complete embolization rate of ruptured aneurysm.All patients with ruptured intracranial aneurysm with SAH were confirmed by emergency cerebral CT scan after admission.The Raymond grading criteria were used to evaluate the embolization effect after operation:grade Ⅰ refers to no development(complete embolization),grade Ⅱ refers to only aneurysm neck development(incomplete embolization),and grade Ⅲ refers to aneurysm body development,in which Raymond grading Ⅰ orⅡ indicates effective embolization.Tirofiban group:4.2 μg/kg tirofiban was intravenously injected after the coil was placed in the aneurysm lumen and the stent was released,followed by maintenance dose 0.07 μg/(kg·min)for 6-8 h,and aspirin 100 mg and clopidogrel 75 mg were given as sequential dual antiplatelet therapy 2 hours before the tirofiban infusion was stopped.Dual antiplatelet group:a loading dose of aspirin 300 mg and clopidogrel 300 mg was given at least 2 hours before stent implantation,and then transferred to aspirin 100 mg and clopidogrel 75 mg given on the second day after operation.All patients received aspirin(100mg/d)for 6 months and clopidogrel(75 mg/d)for 3 months after operation.The efficacy indicators,safety indicators,adverse events and other complications of the two groups were collected and compared.The efficacy indicators were the incidence of thrombotic events during operation and within 72 hours after operation.The safety indicators were the incidence of intraoperative and early postoperative intracranial hemorrhage(within 48 hours after operation),the incidence of late postoperative intracranial hemorrhage(over 48 hours after operation),and the incidence of intracranial hemorrhage related to external ventricular drainage(symptomatic and asymptomatic).The adverse event was the occurrence of drug-related thrombocytopenia.Other complications were delayed ischemic events.The modified Rankin scale(mRS)score was used to evaluate the clinical prognosis of patients at 180 days after operation.mRS score ≤2 was defined as good prognosis,mRS score＞2 was defined as poor prognosis,of which 6 was defined as death.Results(1)There were no significant differences in baseline and clinical data between the tirofiban group and the dual antibody group(all P＞0.05).(2)There was no significant difference in the proportion of patients with good outcome(75.2％[185/246]vs.74.2％[66/89],P=0.845)and death(10.2％[25/246]vs.12.4％[11/89],P=0.566)at 180 days after operation between the tirofiban group and the dual antiplatelet group.(3)There was no significant difference in the incidence of intraoperative(0.8％[2/246]vs.4.5％[4/89],P=0.075)and postoperative thrombotic events(11.0％[27/246]vs.13.5％[12/89],P=0.527)between the tirofiban group and the dual antiplatelet group.(4)Results about safety comparison between this two antiplatelet regimens showed that the incidence of early postoperative intracranial hemorrhage were lower in the tirofiban group than that in the dual antiplatelet group(2.8％[7/246]vs.10.1％[9/89],P=0.014).There were no significant differences in the symptomatic external ventricular drainage related intracranial hemorrhage(0 vs.2/15,P=0.050),incidences of intraoperative intracranial hemorrhage(1.6％vs.3.4％,P=0.580),late postoperative intracranial hemorrhage(3.3％vs.4.5％,P=0.836),and drug-related thrombocytopenia(0.4％vs.1.1％,P=0.461)between the two groups.Conclusion Low-dose tirofiban infusion in SAC for ruptured aneurysms may prevent perioperative thromboembolic events without high risk of intracranial hemorrhage.