Objective To establish a method for the determination of Paracetamol in Zihua Ganmao Capsule. Method Samples were separated on a Kromasil-C18 column with the mobile phase of methanol- water (35∶65), and the detection wavelength was set at 249 nm. Result The calibration curves were linear in the range of 0.165～0.99 ?g (r=0.999 9) for Paracetamol. The average recovery was 98.41% and RSD= 0.64% (n =6). Conclusion The method is accurate and repeatable, and can be used for the quality control of Zihua Ganmao Capsule.