OBJECTIVE:To study the general regularity and characteristics of adverse drug reaction caused by meropenem,and to provide reference for rational use of drugs.METHODS:Vesicle and bullous change occurring in one patient with allergic dermatitis,age of 80,treated with meropenem were analyzed.Literatures about meropenem-induced ADR reported in domestic pharmaceutical journals from Jan.1994 to Dec.2009 were collected and analyzed statistically.RESULTS:Meropenem rarely caused ADR.The most clinical manifestations were diarrhea,rash and abnormality of liver function.CONCLUSION:Meropenem-induced ADR case is rare as well as allergic dermatitis.Great importance should be attached to meropenem-induced ADR.

Objective To explore the incidence of facial hormone-dependent dermatitis, and to raise the healing rate of it. Methods We applied non-steroid drug topically, cold compress combined with anti-histamine agents to treat facial hormone-dependent dermatitis in 68 cases. The results were compared before and after the treatment. Results There were significantly clinical effects of non-steroid drug topically, cold compress combined with antihistamine agents on facial hormone-dependent dermatitis, with healing rate of 82. 4 % , and effective rate of 100 %. Conclusions In order to reduce the incidence of facial hormone-dependent dermatitis, we should follow the principal of applying steroid agent strictly to treat facial dermatitis. Meanwhile, there is significantly clinical effects of non-steroid drug with topical use and cold compress combined with antihistamine agents on facial steroid-dependent dermatitis.

Lens opacity attenuates the contrast sensitivity and clarity of eye due to scattering of light,which leads to poor vision in cataract patients.Phacoemulsification with primary intraocular lens is the primary surgical approach.Some complaints of vision discomfort commonly occur although the vision acuity is good.It is,therefore,vital for us to seek an objective evaluation system of visual quality after cataract surgery.Contrast sensitivity test and visual questionnaire offer valuable input for this issue.Contrast sensitivity can estimate vision function more accurately to better measure visual impairment preoperatively and vision outcome after cataract extraction.

0.05).Comparison group model and normal control:detected the numbers of endothelial cells:①1 month:control group contrast with test group has no changed;②3 month:group 30Gy/N(P

Objective To evaluate the effect and mechanism of ginseng polysaccharides injective solu-tion on invasive ability of human breast cancer MCF-7 cells.Methods Human breast cancer MCF-7 cells were treated with different concentrations of ginseng polysaccharides injections(12.5μL/mL,25μL/mL,50μL/mL or 100μL/mL),and phosphate buffer saline was served as control.The invasive ability,transfer ability and protein expression of matrix metalloproteinases-2 ( MMP-2 ) and matrix metalloproteinases-9 ( MMP-9 ) were determined via transwell matrigel invasive test,scratch test and Western Blot,respectively.Results Ginseng pol-ysaccharide injection on invasive ability and transfer ability in vitro of MCF-7 cell had significant role in inhibi-ting effect,and showed dose and time dependent.After ginseng polysaccharides injection treatment,the MMP-2 and MMP-9 protein expression significantly reduced,and showed dose and time dependent manner.Conclusion Ginseng polysaccharides injection is able to inhibit the invasion and transfer in MCF -7 cells.Moreover,theregulation of MMP -2 and MMP -9 expression may be involved in this effect.

Climacteric syndrome is a common clinical disease with high incidence.The understanding of the disease is progressing in recent years.This article collects thirty-seven documents in this field in recent eight years.The pathogenesis of climacteric syndrome is divided into two aspects as the deficiency of the kidney and the imbalance of the liver, the spleen and the heart.It also sums up the therapy of climacteric syndrome from this two aspects.At last, the authors propose that we should pay attention to the importance of the liver, the spleen and the heart in both the pathogenesis and the therapy.

Objective]To summarize herbal medicine application regulation of Professor Wu Liangcun in gastric cancer treatment. [Methods]Collect 116 gastric cancer patients from Chinese medicine clinic system during January 1,2014 to December 31, 2014 and establish clinical prescription underlying database. Apply descriptive analysis to drug cumulative frequency, drug-induced taste and nature and apply cluster analysis to 42 drugs using more than 10 times. [Results] In the 116 gastric cancer patients,159 kinds of herbs were used ,the cumulative frequency of herbal medicine was 1816.GanCao was the herb with highest usage frequency, and then was FuLing, ShanYao, TaiZishen;According to accumulated frequency, herbs with tonifying function were at the top position(herbs with tonifying qi function were most), and then was the herbs with function of herbs with the function of clearing excessive heat, herbs with function of herbs with the function of relieving dyspepsia, herbs with function of herbs with the function of regulating qi. In terms of herbs' nature and taste, herbs with sweet taste, plain nature were used most. Cluster analysis divided all used herbs into 5 sections, involving prescriptions Sijunzi decoction, Erchen decoction, and couplet medicines DaoYa with GuYa, JiNeijin with MiHoutao, SheShecao with XianHecao and so on. [Conclusions] Professor Wu Liangcun treats gastric cancer with the law of tonifying qi, the main prescription is the same as Sijunzi decoction, emphasizing nourishing Yin and clearing away the heat-evil, protecting gastric, accompanied with promoting digestion and regulating qi.

The proliferation,progression and metastasis of pancreatic cancer are complicated processes caused by muhiple factors.C-X-C motif ligand 5 (CXCL5) can recognize and bind to C-X-C motif receptor 2 (CXCR2),and activate or regulate the expression of signaling pathway by autocrine or paracrine pathway in cells.CXCL5/CXCR2 biological axis plays important roles in proliferation,adhesion,progression,metastasis and prognosis of pancreatic cancer,and is also associated with the angiogenesis and lymphangiogenesis of pancreatic cancer.So,direct or indirect regulation of CXCL5/CXCR2 expression in pancreatic cancer can be effective for target therapy of pancreatic cancer.

OBJECTIVE: To improve the management level in outpatient dispensary.METHODS: The current management model in each outpatient dispensary of our hospital was introduced;the problems were pointed out and the proposals were put forward.RESULTS & CONCLUSIONS: The current outpatient pharmacy management mode and drug control measures of "individual responsibility,weekly small stocktaking,monthly big stocktaking,and irregular spot checks" is feasible,if optimized further,which would help enhance the working quality and service level in pharmacy.