Electric fields have special biological effects for its heating and non-heating effects. Heating effects are about the technology of radio frequency and microwave thermotherapy while non-heating effects are alternating electric field and pulsed electric field. These electric fields have significant effects for tumor treating.

Girdin protein is a kind of actin binding protein,which has the complex molecular structure and takes part in a variety of signaling pathways related with causing cancer.The biological characteristics of Gir-din protein have close association with the proliferation and invasion of malignant tumor.Recent studies have shown that Girdin protein is closely related with occurrence and progress of breast cancer.Girdin protein expres-sion in breast cancer cells can not only promote the progress of breast cancer,but also affect the lymph node me-tastasis and prognosis.Therefore Girdin protein is expected as an independent biomarker to provide a new direc-tion for breast cancer treatment.

Objective:This research is to observe the immunity state of lung cancer by radiotherapy in sync with chemotherapy combined with pingxiao capsule,and to evaluate the effect on the immune function and the existence qualitative of pingxiao capsule in lung cancer.Method:Sixty lung cancer patients were parted into two groups at random,one is simple radiotherapy in sync with chemotherapy,the other is radiotherapy in sync with chemotherapy combined with pingxiao capsule.All the two groups were carried out T-cell subgroup experiment at the beginning and three weeks after the therapy.Results:After therapy CD3,CD4 and CD4/CD8 all indicates significant lower level(P

Objective To observe the evaluation of multi‐tumor marker protein chip in breast cancer with neoadjuvant chemo‐therapy ,and to find high saitivity tumor makers ,then evaluate the clinical significance .Methods Forty health examination persons (control group) and sixty‐four breast cancer patients(experimental group) were accepted with multi‐tumor marker protein chip in‐spection ,then we evaluated the markers of diagnosis .The experimental group patients were accepted four cycles preoperative chem‐otherapy with TAC plan ,and tested multi‐tumor marker protein chip three weeks after therapy .Then we evaluated the clinical sig‐nificance of the markers above‐mentioned .Results The positive rate of CA153 ,CA125 ,CEA and FT was 32% ,27% ,21% and 19% in the experimental group ,it indicated significant change compared with the control group (P<0 .05) .And it indicated signifi‐cant reducing change of CA153 ,CA125 and CEA in the experimental group (P<0 .05) after therapy .The sensitivity would be in‐creased when the four markers were tested combined .Conclusion CA153 ,CA125 ,CEA and FT could be used as assistance diagno‐sis index ;CA153 ,CA125and CEA could keep consistence to the curative effect of neoadjuvant chemotherapy and have clinical value .

Objective To understand the comprehensive quality status of community nurses in Chongqing and seek the development strategy of community nursing education. Methods Related infor-marion was collected through questionnaire investigation in 104 community nurses from 9 community health service center and 18 community health station. Results The mastering degree of various community nursing knowledge was different among nurses with different education background and different profession-al titles (P ＜ 0.05).More than 80% nurses considered it necessary to cultivate comprehensive technique of special courses ,the ability to cope with community emergencies and self-development in their work.78.9% nurses thought they should reinforce the ability in predicting potential problems in community and solving problems by theirselves, Conclusions We need to strengthen the work belief of community nurses,perfect training conditions,optimize course contents and cultivate nurses' comprehensive ability purposely.

ObjectiveTo evaluate the impact of hyperglycemia in patients admitted to medical intensive care units(MICU)on their prognosis.MethodsMedical records of 1016 patients,including 126 cases of known diabetes,359 cases with newly diagnoses hyperglycemia,and 531 normoglycemic cases,admitted to MICU in Wuhan University People's Hospital during September 2006 to September 2007 were reviewed to compare their case-fatality,length of hospital stay,length of MICU stay,mechanical ventilation,blood transfusion and antibiotics use.ResultsIn.hospital case-fatality was 22.8%(82/359)in patients with newly-diagnosed hyperglycemia.significantly higher than that in patients with known diabetes of 12.7% (16/126)and in normoglyeemic cases of 5.1%(27/531)(P＜0.01),and that Was higher in those with diabetes than those with normal blood glucose level(P=0.002).Proportions of patients who needed mechanical ventilation,blood transfusion,antibiotics use was higher in newly diagnosed hyperglycemia group than those in the other two groups.ConclusionsHyperglycemia represents an important mal'ker of poor clinical outcomes and mortality in patients admitted tO MICU.Patients with newly diagnosed hyperglycemia had a significantly higher case-fatality and poorer outcomes than those with known diabetes or normoglyeemia.

Objective To investigate the effects of serum MMP-9,MMP-2 and inflammatory factor levels by intensive lipid-lowering therapy in patients with acute myocardial infarction.Methods A total of 76 cases with acute myocardial infarction from May 2012 to October 2016 in our hospital were collected and randomly divided into control group and experiment group with 38 cases in each group.Patients in the control group were treated by clinical routine lipid-lowering(simvastatin 20mg/day); patients in the experiment group were treated by clinical intensive lipid-lowering(simvastatin 80mg/day),treated for two weeks.Observed the serum MMP-9,MMP-2 and inflammatory factor levels changed of the two groups before and after treatment,explored the validity and security of intensive lipid-lowering therapy in the treatment of patients with acute myocardial infarction.Results After treatment,the clinical efficacy of the experiment group was better than control group,performanced as: the serum MMP-9 and MMP-2 levels of the experiment group were more lower than the control group; the serum hs-CRP,TNF-αand IL-6 levels significant lower than the control group,the above results had statistical significance(P<0.05).The adverse reactions of the experiment group were slight,back to normal after stopped drugs.Conclusion Intensive lipid-lowering therapy in the treatment of patients with acute myocardial infarction can significantly reduce serum MMP-9 MMP-2 and inflammatory factor levels,and high safety.

Objective To explore the role of hemoglobin (Hb) level in mortality and morbidity of chronic kidney disease (CKD)patients,aiming to give some evidence for therapy of anemia.Methods Randomized,clinical trials (RCTs) were identified by searching Medline,Embase and the Cochrane library.All the analyses were performed using the Revman software available free from the Cochrane collaboration.Results Twenty-three trials involving 10 204 patients were identified.Overall,the high Hb target was associated with increased risk of all-cause mortality (RR=1.10,95％ CI 1.00 to 1.21),hypertension (RR=1.40,95％ CI 1.12 to 1.75),stroke and hospitalization (RR=1.07,95％ CI 1.00 to 1.14) compared with low Hb target (P＜0.05).No significant difference was found in the risks of non-fatal mycardial infarction (RR=1.13,95％ CI 0.79 to 1.62) and renal replacement therapy (RR =1.00,95％ CI 0.85 to 1.18).Conclusions Targeting low Hb target is beneficial to CKD patients based on reduced risk of hypertension,hospitalization,stroke and all-cause mortality.However,no significant difference is found in non-fatal mycardial infarction and renal replacement therapy.

Objective To observe the effect of transperineal injection of botulin A toxin on patients with detrusor-external sphincter dyssynergia caused by spinal cord injury. Methods Transperineal injection of botulin A toxin were performed in 6 patients with spinal cord injury (3 with cervical spinal cord injury and 3 with thoraco-lumbar spinal cord injury) complicated by detrusor-external sphincter dyssynergia.55 U of botulin A toxin was injected twice separately. The interval between 2 injections was 3 days.Before treatment, the residual volume of urine after voiding was determined and the maximum urethral pressure was measured by urodynamic testing.One month after treatment the examination mentioned above was repeated. Results The decrease in residual volume of urine was (133.3?70.9)ml.The decrease in maximum urethral pressure was (35.4?25.8)cmH 2O(both P

Objective: To detect the expression profile of NDRG1 gene in different tissues and cell lines and explore the relationship of NDRG 1 with liver tissue differentiation and hepatocarcinogenesis. Methods: The expression profiles of NDRG 1 in hepatocellular carcinoma (HCC) tissues, paired noncancerous liver (PNL) tissues, adult normal liver (NL) tissues, baby mouse liver tissues and fetal liver tissues in different developmental stages and cultured cell lines were performed using RT PCR and Northern Blot analysis. Results: Expression of NDRG 1 was significantly up regulated in HCC tissues compared to that of NL tissues and PNL tissues, however, the expressions of NDRG1 in NL and PNL tissues showed no evident difference. In ten cell lines, the highest expression was in the 293T human kidney cell line, the next one in liver cell L02, and the lowest one in the undifferentiated HLE cell line. Expression of NDRG1 in liver tissues enhanced with the development of the baby mouse and human fetus. Conclusion: NDRG 1 is probably related to the liver cell differentiation and is highly expressed in the specific stage of the differentiation. However, it could not be recognized as a marker of differentiation. The high expression of NDRG 1 in HCC indicates that HCC is not just distributed to a simple de differentiation. Much more study is necessary in understanding the comprehensive relationship of the disorder proliferation and differentiation of HCC and the related genes.