Objective To evaluate the clinical efficacy of acupuncture at the eight confluent points in treating perimenopausal syndrome (PMS). Method Sixty PMS patients were randomized into an acupuncture group of 30 cases and a Western medication group of 30 cases. In the acupuncture group, bilateral Gongsun (SP4), Neiguan (PC6), Zulinqi (GB41), Waiguan (TE5), Lieque (LU7), Shenmai (BL62), Houxi (SI3), and Zhaohai (KI6) were selected, 30 min for each treatment, once a day, 10 d as a treatment course; the treatment was given 15-18 d after each menstruation cycle, while for the menopausal patients, the treatment could start anytime. The Western medication group was prescribed with Tibolone tablets, 2.5 mg per dose, once a day, 30 d as a course. The intervention lasted 3 months for both groups. The Kupperman Index, serum estradiol (E2), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) were observed before and after treatment, and the statistical results were then analyzed. Result Serum E2, FSH, and LH were significantly changed after intervention in both groups (P<0.05), and the increase of serum E2 in the acupuncture group was more significant than that in the Western medication group (P<0.05). The Kupperman score decreased significantly in both groups after intervention (P<0.05), and the improvements of symptoms in the acupuncture group were more significant than that in the Western medication group (P<0.05). The total effective rate in the acupuncture group (96.7%) was significantly higher than that in the Western medication group (83.3%). Conclusion Acupuncture at the eight confluent points is effective in treating PMS, and its therapeutic efficacy is more significant than that of the Western medication.

Objective To discuss the prenatal diagnosis of abnormalities of fetal limb bone.Methods We selected 18 cases which long bone of fetus less than 2SD of average volume of gestational weeks or long bone changed into angle or other fetus's abnormalities by first B-mode ultrasonic. All above cases was delivered at Capital Medical University of Obstetric and Gynecological Hospital during Jan. 2006 to Dec. 2009. We B-mode ultrasonic was used to measure fetus's biparietal diameter (BPD) ,femur length (FL) ,abdominal circumference(AC) ,head circumference(HC) ,humerus length (HL) ,amniotic fluid index (AFI) and structures of organ and calculated FL/AC, growth speed of long bone. The standard of achondroplasia is that FL and HL are less than 4SD of average of gestational weeks or FL/AC less than 0. 16. The standard of Osteogenesis Imperfecta is fetal long bone of fetus shows short and thick, curves into angle, fracture in uterus by X-ray, or skull shows thin or sink by X-ray. Results (1) By B-mode ultrasonic and X-ray exam of all 18 cases: 7 cases shows that HC ＞2SD, 10 cases shows too much amniotic fluid, 12 cases shows AFI ＞ 18.0, 9 cases shows abnormalities of narrow cavitas thoracis, disordered vertebral column, or unusual architecture of heart. For cases 1 to 14 are achondroplasia, among which,11 cases are FL＜4SD and HL＜4SD, 2 cases are FL ＜3SD and HL ＜4SD, 1 case is not only FL ＜2SD and HL ＜3SD but also hydroncus all over the body of fetus. The growth velocity of long bone of fetus in all the 14 cases is more slowly than the normal rate. For all the above 14 cases, 12 cases FL/AC ＜0. 16, 1 case FL/AC =0. 19, 1 case FL/AC =0. 20. The length of femur or humerus is shorter than the normal rate and have other abnormalities the above last two cases. For case 15 and 16, they don't show any abnormalities of bone growth though one year's follow up studying. For case 17 and 18, they are osteogenesis imperfecta. (2) The result of fetal perinatal period fate and autopsy: there are 8 female and 10 male in all the 18 cases. One case is labored after 39 weeks pregnancy, and it is low birth weight infant, weight ＜3%th. All the other cases are normally birth weight infant. All the 18 cases of abnormalities of fetal limb bone are examined by chromosomes check, among which, 9 cases are amniocentesis, 7 cases are cordocentesis,2 cases are checked chromosomes by fetus cord blood, all the caryotype are normal. In the 16 autopsy cases,14 cases are achondroplasia or hypochondroplasis. It can be seen amplifying extremities, hyperplasia chondrocytes of tubiform born, karyomegaly, anachromasis, hyperplasia capillaries though microscope and grow up into cartilage irregularly. Also can be seen hyperplasia chondrocytes of epiphyses, delaying osteosis.2 cases are osteogenesis imperfecta. It can be seen broadening of metaphyses, exility of bone trabeculae. For the other two cases which the fetus is alive, we do the follow up studying to their one year old one of them is low birth weight new born, their limb and height are all normal. Conclusions To diagnose fetal Achondroplasia, it is not only based on the significantly shorter of femur or humerus length but also based on the dynamics observing the long bone growth velocity and calculating FL/AC. For osteogenesis imperfecta fetus, it should be diagnosed by fractures in uterus though X-ray.

Nanoparticule (NP) as a drug and gene carrier has shown great potential and has been widely studied. Due to its ultra-small size, NP can achieve intelligent delivery of drugs, such as deliver drug site-specifically to disease focus or targeted tissue, even into target cells. The carrier materials of NPs provide it with such advantages as shielding odor, long-term sustained releasing of drug, lowering uoxicity,extend biologic half life of drug and gene, etc. This review emphasizes the manufacturing techniques and application of nanoparticles as drug and gene delivery system.

Objective To observe the clinical efficacy of acupuncture at Jiaji (EX-B 2) in treating irritable bowel syndrome (IBS). Methods Sixty IBS patients were randomized into a treatment group and a control group, 30 in each group. The treatment group was intervened by electroacupuncture at Jiaji (EX-B 2), while the control group was by oral administration of Pinaverium Bromide tablets. The Bowel Symptom Scale (BSS) was adopted for observation before and after intervention, and the clinical efficacies were also compared. Results After intervention, the BSS scores were significantly changed in both groups (P<0.01). There was a significant difference in comparing BSS score between the two groups after intervention (P<0.01). The excellent rate was 86.7%in the treatment group versus 50.0% in the control group, and the difference was statistically significant (P<0.05). Conclusions Acupuncture at Jiaji (EX-B 2) is an effective approach in treating IBS.

Ovarian cancer is the highest death rate of gynecologic malignant tumor .Currently,people rec-ognize standard treatment for ovarian cancer was that reduction -Tumor cells of platinum based chemotherapy af-ter surgery.But for those patients who have developed into advanced cancer that cannot be operated the surgeries directly,the application of preoperative Neoadjuvant chemotherapy ( NACT) does have the superiority .which is recognized by the majority of clinical doctors ,and has been widely used in the treatment of advanced malignant tumor.It is worthy to discussing which part of patients should choose the initial treatment of Neoadjuvant chemo -therapy,rather than a direct treatment of destroying tumor cells .This article is summarizing the empirical cases based on related research ,in order to help clinicians to make a decision on the treatment of ovarian cancer .

Objective To evaluate the diastole asynchrony of the different segments of left ventricle(LV) and its relation with LV diastole function in the patients with hypertrophic cardiomyopathy (HCM) by quantitative tissue velocity imaging(QTVI).Methods Forteen normal controls,15 patients with non-obstructive HCM (HCM) and 12 patients with obstructive HCM (HOCM) were studied by QTVI.The regional velocity profiles of 18 segments of LV and mitral annulus of six walls along LV apical long axis view,apical two chamber view and four chamber view were obtained.The time (T_ Q-E ) from onset of QRS complexes to peak velocity during early diastole were measured.The maximal difference in T_ Q-E with in the same wall (Intra-?T_ Q-E ),the same segment (Inter-?T_ Q-E ),all 18 segments (Max-?T_ Q-E ) of LV and the mean ratio of mitral annulus early and late diastole peak velocity of six walls were calculated(Ea/Aa′).Interventricular septum basic thickness(IVSTh) and LV outflow tract gradient(LVOTPG) were measured.Results Inter-?T_ Q-E ,Intra-?T_ Q-E ,Max-?T_ Q-E were significantly prolonged and Ea/Aa′ was reduced in HCM and HOCM groups compared with control group.There was no statistically significant difference of Inter-?T_ Q-E ,Intra-?T_ Q-E ,Max-?T_ Q-E ,Ea/Aa′ between HCM and HOCM groups.In control group,HCM group,HOCM group,IVSTh and LVOTPG were increased little by little.Max-?T_ Q-E were correlated negatively with Ea/Aa′ in patients with HCM and HOCM.IVSTh and LVOTPG were mildly correlated with Ea/Aa′ in HOCM group,but not correlated with Ea/Aa′ in HCM.Conclusions Asynchrony diastole is a neccessary factor causing impairment of LV diastole function exists within the same wall and the same segment of LV in patients with HCM,but IVSTh and LVOTPG is not a neccessary factor causing impairment of LV diastole function.Asynchrony diastole in patients with HCM could be an appereance of cardiomyopathy.

Objective To evaluate the asynchrony of right ventricle(RV) and its significance in idiopathic pulmonary artery hypertension(IPAH) patients by quantitative tissue velocity imaging.Methods Twenty-five normal people,26 IPAH patients were studied.RV structure parameter(thickness of lateral wall,late diastolic and systolic area and fractional area change) and function parameter [peak systolic velocity(Sa),early diastolic velocity(Ea),late diastolic velocity of tricuspid annulus of lateral wall and Tei index] were measured and calculated.Regional velocity profiles of 6 segments of RV were obtained.The time from onset of QRS complexes to Sa and Ea(T_(Q-S),T_(Q-E)) of 6 segments were measured.The maximal difference in T_(Q-S) and T_(Q-E) in the same wall(Intra-?T_(Q-S),Intra-?T_(Q-E)),the same segment(Inter-?T_(Q-S),Inter-?T_(Q-E)) and all 6 segments(Max-?T_(Q-S),Max-?T_(Q-E)) were calculated.Results Compared with controls,Inter-?T_(Q-S),Inter-?T_(Q-E),Max-?T_(Q-S) and Max-?T_(Q-E) were significantly prolonged in IPAH patients(P(0.05)).Max-?T_(Q-S) and Max-?T_(Q-E) were correlated with structure and function parameter in IPAH patients.Conclusions Asynchrony exists in RV and have good relation with RV structure and function in IPAH patients.

Next-generation sequencing (NGS) platforms have recently evolved to provide an accurate and comprehensive means for the detection of molecular mutations in acute myeloid leukemia(AML).The 54th ASH annal meeting reported lots of studies on NGS in AML,reflect the important role of the NGS technology in modern diagnosis and treatment of blood diseases and the impact on the future development of the blood disease.

A comparative study on the histological and morphological characteristics and the intrinsic quality of the roots of Huabei Qianhu(Peucedanum harry-smithii),Shaomao Bei Qiau hun (P.harry-smithii var.subglabrum ) and Baihua Qianhu (P.praeruptorum ) was carried out. Results revcaled that the former two Qianhu produced in Gansu are similar to Baihua Qian hu in their main ingredients.Thus the two Qianhu are worthy for further research and develo pm ent.At the same time, it was observed that Baihua Qianhu Produced in Gansu is of iuferior quality and the content of EtOH extraet of its root is slightly lower than that from elsewhere in China.

Adult ; Drug Combinations ; Drugs, Chinese Herbal ; therapeutic use ; Fatty Liver ; drug therapy ; Female ; Humans ; Male ; Middle Aged ; Phytotherapy ; Powders