Apart from the direct causality link of emotion and health,emotions also affect health indirectly through hormone production,immune function,symptom perception,to seek treatment,treatment decisions and adhere to treatment,health behavior,and so.Medical professional norms also gradually require doctors helping patient to aware their emotions and use adaptive strategies to regulate their emotions.Emotion-focused therapy has important significance for this occupational capacity.

Objective Research of chromosome’s influence and curative effect on first and second generation tyrosine kinase inhibitor therapy to CML patients.Methods Giving conventional genetic analysis to 80 Ph+ CML patients,and contrast CML patients’chromosome changing situation with first and second generation tyrosine kinase inhibitor therapy.Results There were 1 1 cases with other abnormalities of chromosome number and structure in 80 cases of Ph+ CML patients,and 10 cases were resistant or intolerant to imatinib.35 patients (87.5%)achieve sustained complete cytogenetic remission (CCyR)who treated with imatinib (TKI-Ⅰ)in the total 40 cases,in these 35 patients,7 cases (17.5%)got CCyR in 3 months;10 cases (25%)got CCyR in 6 months,13 cases (32.5%)got CCyR in 12 months,and 5 cases (12.5%)got CCyR in 18 months.33 patients (82.5%)achieve sustained completecytogenetic remission (CCyR)who treated with dasatinib/nilotinib (TKI-Ⅱ)in the total 40 cases,in these 33 cases,16 cases (40%)got CCyR in 3 months;9 cases (22.5%)got CCyR in 6 months,5 cases (1 2.5%)got CCyR in 1 2 months,and 3 cases (7.5%)got CCyR in 1 8 months.Conclusion Ph+ CML patients combined with other chromosome abnormity were more easily to be resistant or intolerant to imatinib,espe-cially in acceleratd phase and blastic phase.First and second generation tyrosine kinase inhibitor have little difference to treat with CML patients in long time efficacy,but the second generation effect is better than first generation in short time effica-cy.

In the interpersonal communication conflict is one of the social interactions that occurs frequently.Negative emotion influences the lif estudy and health condition of college students.The psychological healthy education of college students should improve their psychological health condition level through changing their unreasonable belief,decreasing the emotional sensitivity to conflicts,analyzing the emotion to conflicts corretcly so on.

Objective: To compare the advantages and disadvantages between Prospective Payment System based on Diagnosis Related Group System ( DRGs-PPS) mode and project payment mode. Methods: Historical review method, sampling and comparison are used to compare and analyze DRGs-PPS mode and project payment mode. Results: Through comparative analysis, it is founded that the application of DRGs-PPS mode could make the three wins of government, medical institutions and patients, which has more advantages than project payment mode. Conclusion: DRGs-PPS mode has important influences in controlling the increase of social health expenditure, improving the quality of medical services and standardizing medical behaviors.

Acute Disease ; Adolescent ; Adult ; Aniline Compounds ; poisoning ; Humans ; Male ; Middle Aged ; Occupational Diseases ; chemically induced ; diagnosis ; drug therapy ; Poisoning ; diagnosis ; drug therapy

Objective To investigate potential mechanism of decreasiy leptin level of Pseudostellaria Polysaccharides on experimental diabetic rats. MethodsThe diabetic rats were induced by the abdominal cavity injection of alloxen(ALX) 200 mg· kg-1. The levels of leption and TNF-α were determined. Results Pseudostellaria Polysaccharides (0.6 g·kg-1 , 1.2 g·kg-1 ) could increase Leptin level and could decrease TNF-α level of DM rats(P＜0.05 or P＜0.01). Conclusion Pseudostellaria Polysaccharides can play an threpedtic rale in the experiment aldialetic rats through multi-pathway the experimental diabetic rats.

Objective To evaluate the efficacy of different doses of dezocine for decreasing the minimum alveolar concentration (MAC) of desflurane.Methods ASA physical status Ⅰ or Ⅱ patients of both sexes,aged 50-70 yr,undergoing elective lower abdominal surgery performed under general anesthesia,were divided into 4 groups:control group (group C)and different doses of dezocine groups (D1,D2 and D3 groups).Before induction of anesthesia,in D1,D2 and D3 groups,dezocine 0.050,0.075 and 0.100 mg/kg were intravenously infused,respectively,while in group C,the equal volume of normal saline was given instead of dezocine.The adverse reactions were observed.Propofol 3 mg/kg was given for induction of anesthesia 15 min later until patient' s consciousness and spontaneous respiration disappeared.Laryngeal mask airway was inserted and the patients were mechanically ventilated.Up-and-down sequential allocation was used to determine the MAC of desflurane during maintenance of anesthesia.The end-tidal concentration of desflurane was set at 8.0％ and maintained at this level for at least 5 min before skin incision in the first patient.Each time the concentration of desflurane increased/decreased in the next patient depending on whether or not the body movement developed.The ratio between the two successive concentrations was 0.9.The point between the positive response and negative response served as a cross-over point.After at least 7 independent cross-over points were observed in each group,the experiment was stopped.The MAC and 95 ％ confidence interval of desflurane were calculated.Results No adverse reactions developed in each group.The MAC of desflurane was significantly lower in D1-3 groups than in group C,in groups D2.3 than in group D1,and in group D3 than in group D2.Conclusion Dezocine 0.100 mg/kg injected intravenously at 15 min before induction of anesthesia provides a better efficacy for decreasing the MAC of desflurane in the patients.

Objective To explore the relation between serum TGF?1 and diabetic nephropathy(DN). Methods Forty-five cases of type 2 diabetes mellitus patients were divided into three groups according to urine albumium excretion rate (UAER): normoalbuminuria (NA)group; microalbuminuria (MA) group; macroalbuminuria group (overt DN). Serum TGF?1, fasting blood glucose (FBG), HbAlc.BUN. Cr. Ccr were detected in all cases. Microalbundnuria group and macroalbuminuria group were respectively divided into group.treated with captopril and regular treatment group. Results Serum TGF?1, had significantly differences in four groups(23. 95?8. 01ng/ml vs 35.02?6. 70ng/ml, 39.3i? 5. 35ng/ml vs 58. 58?9. 56ng/ml,P

Polymerase chain reaction was employed to amplify the HBV X gene from plasmid pCP10, and the product was cloned into pVR1012, then transfected HepG2 cells and cotransfected HepG2 cells with reporter plasmid pSV lacZ HBx protein produced by HepG2 cells was measured by ELISA method The activity of ? galactosidase was measured by a kit, which reflected the transactivating function of HBx protein The results showed that HepG2 cells transfected by pVR1012 X could express HBx protein The expression of ? galactosidase in HepG2 cells transfected by the pVR1012 X was 3 2 fold higher as that of control plasmid It is suggested that the recombinant plasmid pVR1012 X can be expressed in mammalian cell line, and has transactivating effect on SV40 early promoter

To investigate the relationship between the diameter of abdominal aortic aneurysm(AAA) and the concentration of elastin, forty five healthy male Wistar rats were selected,5 rats of them were used as normal control, the other 40 rats were randomly divided into 2 groups. A 1 cm segment of the abdominal aorta of the rat was isolated and perfused with pancreatic elastase in the experimental group, and the control group was given normal saline solution. Laparotomy was performed immediately after operation and on the 2, 7, 14 day, the aortas were measured and harvested. Histological studies were carried out to analyze the changes in elastin. The aortic diameter progressed to aneurysmal dimension in the experimental group. Histological study revealed loss of elastin in tunica media of the aorta in the experimental group. Neither macroscopic nor microscopic lesions were found in control group. It is suggested that there is a significant correlation between the aortic diameter and the decreased elastin content.