Vascular endothelial growth factor can induce angiogenesis in vivo.Phosphoinositide 3-kinase signaling pathway widespreads in cells,which plays important roles in cell growth,proliferation,differentiation,and angiogenesis.The phosphoinositide 3-kinase signaling pathway can activate vascular endothelial growth factor,such as hypoxia-inducible factor-1,insulin-like growth factor-Ⅰ,nitric oxide synthaseand cyclooxygenase-2.The present studies have shown that the vascular endothelial growth factor and phosphoinositide 3-kinase signaling pathway play an important role in the retinopathy of prematurity.

0.05). But the Wuling Sang could obviously decrease serum TG content than Simvastatin(P0.05). The adverse drug reactions were stomach discomfort(4 patiens in SWS) group, 5.71%), abdominal discomfort(2 patiens in Simvastatin group, 4.55% ) and sleeplessness(5 patiens in Simvastatin group, 11.4%) . CONCLUSION: The results show the TCM drug SWS is effective and softy on treating the patients with primary hyperlipemia.

Liver cirrhosis is the advanced stage of various chronic liver diseases,and its complications include portal hypertension,esophageal and gastric varices,hepatocellular carcinoma,etc. Transient elastography( TE),a noninvasive method for liver stiffness measurement( LSM),has been used widely to detect liver fibrosis qualitatively and quantitatively. Recently,correlations were observed for LSM with liver cirrhosis and its complications. This article reviewed the studies focused on these correlations,as well as the clinical application of TE.

Nosocomial infection is a serious problem in the diagnosis, treatment and management of neonatal disease. Neonatal intensive care unit (NICU) is high risk place for nosocomial infections whose clinical features vary with age, nation and region. The improvemnts in hand hygiene measures and antibiotic stewardship and control of the risk are recommended to effectively prevent nosocomial infections in NICU and to improve the healthcare service in neonates.

OBJECTIVE To investigate the advantages of nicardipine induced hypotension in endoscopic sinus surgery.METHODS Eighty patients underwent endoscopic sinus surgery under general anesthesia were randomly assigned into two groups(n=40 each):Group A(Enflurane Group), Group B (Nicardipine Group).The effect of controlled hypotension was compared between the two groups.The changes of MAP, HR were recorded during induced hypotension, the time of induction, maintenance and recovery in induced hypotension were recorded.RESULTS 1.The induced hypotension induction time in group A was significant shorter than that in group B, BP recovery time in group A was obviously longer than that in group B (P

In 54 cases of pulmonary hypertension, the PaCO2 was markedly lowered, PaO2 and SaO2 elevated, HR, CO and mPAP, PVR all lowered in the treatment group (P0. 05), but SBP was significantly different (P

Objective To explore the cognition processes of language in stroke patients by characterizing the differences between the event-related potentials (ERPs) N400 evoked bypicture-word andsentence-wordparadigms.Methods Twenty patients with a single brain lesion resulting from a first episode of stroke were tested along with 20 normal controls.Their N400 ERPs were tested using pictures and sentences as activating stimuli and phrases composed of nouns and verbs as the target stimuli.The N400 potentials were recorded from electrodes located at Fz,Pz,T3 and T4 positions of the International 10-20 system.The N400 latencies and amplitudes and the behavioral responses of the experimental and control groups were compared.Results The latencies were longer and the amplitudes were lower in response to sentence activation than to picture activation.The differences in terms of amplitude were the greatest with N400 recorded from Pz.The responses to the target stimuli were not significantly different with regard to the types of stimuli and recording location.The average response time was longer and the error rate was higher in response to sentence activation than to picture activation.Conclusion Multiple accesses,activating stimuli and integrating processes are involved in language cognition.The brain is more sensitive and accurate in response to picture stimuli in language cognition.The response to sentence stimuli is slower,and the error rate is higher.This suggests that it is better to usc varied prime stimuli in teaching children languages.

Cardiopulmonary bypass(CPB) can induce systemic inflammatory response syndrome(SIRS).This review elaborated the influences of SIRS in acute lung injury after CPB.

Despite the continuous improvement of cardiopulmonary bypass(CPB),renal dysfunction remains a frequent complication of cardiac surgery.Previous studies reported that the incidence of acute renal dysfunction following CPB was 7%-40%,while that of acute renal failure(ARF) was 1%-10%.In those who developed ARF,the prognosis was poor,with mortality of about 40%-80%.The present paper reviews the mechanism,risks and available preventive measures of acute renal injury following CPB.

With the development of coronary artery recanalization technology,more and more attention are paid to myocardial ischemia-reperfusion injury.PPAR-? is distributed in rat myocardium.Besides insulin sensitizing effect,the ligands of PPAR-? can also exert its protective effects by inhibiting cell inflammatory response and apoptosis.In this review,the author summarized the research advances of the protective effects of the ligands PPAR-? on myocardial ischemia-reperfusion injury.