Bispheno|A(BPA)is an endocrine disruptor with estrgenic properties,which is a widely used industrial platicizer.When exposure to BPA for long-term,it would impact on multiple systems and organs including reproductive.developmental,neurological,endocrine function and so on,particularly in obesity.ExpoSUre to BPA during pregnancy and postnate,it can increase the sensitivity to obesity in offsprings.BPA may be contributed to obesity by enhancing triglyceride accumulation and accelerating adipocytes differentiation,affecting endocrine function of adipocytes and blood glucose and insulin metabolism.However,the dosage effect of BPA is not a simple linear rehionship.The impact of environment-related dosage on the human is worthy ot research in future.

ObjectiveTo compare the clinical efficacy and side effects of liver damage of the methylprednisolone (methylprednisolone tablets ) and prednisone treating nephrotic syndrome compicated with hepatitis B.Methods66 patients with nephrotic syndrome complicated with hepatitis B were randomly divided into control group and observation group,and each group had 33 cases.The control group was given prednisone in the morning,while the observation group was received methylprednisolone.The clinical efficacy and side effects of liver damage were compared between the two groups.ResultsAfter the treatment,the biochemical index significantly improved compared with the pre-treatment( all P ＜ 0.05 ) ;The total effective rate of observation group was 93.94％ higher than 84.85％ of the control group( x2 =1.44,P ＞ 0.05 ).However,there was no significant difference between the two groups( P ＞0.05) ;The observation group was significantly higher than the control group in negative rate of HBV-DNA (x2 =4.69,P ＜ 0.05 ) ;The side effects of liver damage in the observation group were lower than the control group (t =5.62,5.13,P ＜ 0.05 ).ConclusionMethylprednisolone and prednisone for treating patients with nephrotic syndrome compicated with hepatitis B had good clinical efficacy,and methylprednisolone was more effective than prednisone,especially it had less side effects of liver damage than prednisone.

Objective To investigate the causes and characteristic of placental abruption.Methods Clincal data of 52 patients with placental abruption were retrospectively analyzed.Results Compared with other incentives,gestational hypertension disease(especially in the severe group)had a significant difference (P ＜ 0.05),but in this group of materials due to placental premature rupture caused by placental abruption are light;on two groups of children to mode of delivery were compared,the difference was statistically significant (P ＜ 0.05) ;on two groups of maternal postpartum were compared,the difference was statistically significant (P ＜ 0.05) ; the two group of fetuses were compared,the difference was statistically significant(P ＜ 0.05).On 7 cases of fetal asphyxia of active treatment were cured.Conclusion In order to further reduce the incidence of placental abruption should the knowledge of this disease is caused take seriously,strengthen to the prevention of the disease as well as publicity and education,and further improve the prenatal diagnosis and treatment level,as the child 's life to provide security protection.

Objective:To investigate the effect of sonodynamic therapy with hematoporphrin on the expression of VEGF in Chick Chorioallantoic Membrane and provide experimental basis for appling sonodynamic therapy(SDT)on anti-angiogenesis in tumor therapy.Methods:The hatching eggs cultured for 7 days were randomly divided into 4 groups:blank control group,ultrasound group,hematoporphrin group,sonodynamic therapy group.The express of VEGF in CAM was detected by immunity histochemistry.Result:There were significant differences between control group and ultrasound group(P0.05),conclusion The results show that sonodynamic therapy with hematoporphrin has a significant inhibitionary effect on the express of VEGF in CAM and this maybe is the most important mechanism of its anti-angiogenesis effect.

Real-time three-dimensional echocardiography(RT-3DE) has been validated for its accurate diagnoses and quantitave mearsurement of mitral valve disease,which could act as a guide in selecting the proper therapeutic strategy for each individual in clinical setting.In this article,the recent research achievements on RT-3DE in mitral valve disease were summarized,and the application of RT-3DE in surgical approach to mitral valve disease was discussed as well.

Objective:This study explores Achenbach's three famous checklists regarding to children's behavior problems:CBCL,YSR,TRF.The checklists are translated into Chinese and tested for their relativity and applicability.Methods:1410 adolescents selected from 6 middle schools in Beijing are investigated with CBCL,YSR and TRF.Results:The Cronbach ? among the items of the three checklists and the total score are 0.96,0.95,and 0.99 respectively,the split-half reliability are 0.93,0.89,and 0.97 respectively,which demonstrates an obvious homogeneity within the three checklists.Scores in YSR are generally higher than those of the other two checklists, scores in CBCL follow immediately,and scores in TRF are the lowest(except for a minority of individual factors). The scores in CBCL and YSR are significant correlated(r=0.35～0.60,P

Objective To observe the effects of chemotherapy on the peripheral blood lymphocyte sub-cluster in patients with ovarian cancer .Methods Sixty-two patients with ovarian cancer who accepted chemo-therapy from Jan 2007 to Mar 2013 in our hospital were collected .Sixty healthy women in our hospital were used as control.The expressions of CD3,CD4,CD8 and CD25 in peripheral blood lymphocyte of ovarian cancer patients before,one week and one month after chemotherapy and healthy women were detected and analyzed .Results The ratio of CD3 +and CD4 +T cells and CD4 +/CD8 +in patients with ovarian cancer were significantly lower than those in healthy .Whereas the ratio of CD4 +CD25 +T cells in patients with ovarian cancer was significantly higher than that in healthy women .No significant differences were observed in ovarian cancer patients with differ-ent clinical stage .There were no significant changes that observed one week after chemotherapy in patients with o -varian cancer .These indexes improved notably one month after chemotherapy .These indexes in effective group one month after chemotherapy were significantly better than those in inefficient group .Conclusion The ratio of pe-ripheral blood lymphocyte sub -cluster in patients with ovarian cancer was imbalance .Dynamic monitoring the changes could guide the therapy and judge the curative effect and prognosis .

Age-related macular degeneration (AMD) can cause irreversible severe visual impairment.At present,a large number of basic and clinical research has documented several effective treatment for wet AMD.As for dry AMD,so far there is no effective therapy and preventive measure.Dry AMD probably worse for macular choroidal neovascularization (CNV) or geographic atrophy (GA) to its later stage,resulting in severe visual impairment.In recent years,some promising treatment strategies are emerging,mainly in the prevention of the damage of photoreceptor and retinal pigment epithelium,such as drug therapy,laser photocoagulation,surgery,plasma exchange,stem cell transplantation and gene therapy.These therapies are expected to be able to bring hope for arresting the development of dry AMD.This article reviews the current researches and possible future management of dry AMD.

Age-related macular degeneration (AMD) is the leading cause of the irreversible vision loss in population over 55 years of age.With the increasingly serious problem of aging,the prevalence of AMD is rising year by year.However,as the pathogenesis of dry AMD is largely unknown,the effective therapy still is lack.Given that there was a lack of proper animal models,it brought about obstacles to researches about molecular mechanism underlying dry AMD.Nowadays,lots of murine models of dry AMD have been established and developed,which provide suitable tools for relevant researches.But,different dry AM D models show varied pathogenesis features,and a reasonable choice of models is very important for different studies.The characteristics of different dry models were reviewed in this article.

Collaborative inquiry applied in teaching of literature retrieval course is beneficial for the unity and cooperation between teachers and students,and their independent study ability. Described in this paper is the collabo-rative inquiry in teaching of information retrieval course with its target, methods and program carefully designed for medical postgraduates according to the students-oriented construction theory, which can promote the growth up of teachers and students, and learn the frontier and innovative theories, and practical knowledge.