Matrix metalloproteases(MMPs)and tissue inhibitors of matrix metalloproteases(TIMPs) have a co-regulation of changes of the extraeellular matrix(ECM).MMPs can control the proteases which are related to the process of tumor development.Moreover,MMPs,produced by host cells including inflammatory ceUs,endothelial cells,pericytes and fibroblasts have a positive or negative correlation with tumor formation.

Climacteric syndrome is a common clinical disease with high incidence.The understanding of the disease is progressing in recent years.This article collects thirty-seven documents in this field in recent eight years.The pathogenesis of climacteric syndrome is divided into two aspects as the deficiency of the kidney and the imbalance of the liver, the spleen and the heart.It also sums up the therapy of climacteric syndrome from this two aspects.At last, the authors propose that we should pay attention to the importance of the liver, the spleen and the heart in both the pathogenesis and the therapy.

Inflammatory bowel disease is a chronic non-specific intestinal tract inflammation,currently,its etiology and pathogenesis are not clear.The current conventional treatments include salicylic acid drugs, steroids, immunosuppressive agents, biological agents and surgery, but the prognosis is still not very optimistic.In recent years, a variety of other treatment options have emerged, such as anti-cytokine antibody, anti-chemokine antibodies.Clinicians pay more attention to treatment of inflammatory bowel disease.

Objective To give a systematic reviews on effect of taking blood gas via cephalic artery for infants.Methods Meta-analysis were used to analyze literatures about taking blood gas via cephalic artery for infants.Results 11 studies were included.The rate of successful puncture was 87.5％～98.0％ in the intervention group and 55.3％ ～94.6％ in the control group.The rate of successful puncture via cephalic artery were higher.Conclusions Effect of taking blood gas via cephalic artery for infant was better than that via other artery.Successful rate was high,while the incidence rate of local side effects was low.

Objective To study the association of apolipoprotein ( Apo) E gene polymorphism with difference in biochemical metabolism of diabetic nephropathy of Hui and Han populations. Methods ApoE genotype was determined by PCR-RFLP in diabetic patients with or without diabetic nephropathy (DN) and normal peoples in Hui and Han peoples, the related biochemical parameters were simultaneously detected. Results (1) Huis had 3 genotypes, i. e. E2/E3, E3/E3 and E3/E4, and their frequencies were 0. 043, 0. 894 and 0. 064, respectively. Hans had 5 genetypes, i. e. E2/E2, E2/E3 , E2/E4, E3/E3 and E3/E4, and their frequencies were 0.075,0.060, 0.164, 0.642 and 0.060, respectively. The frequencies of 3 alleles, E2, E3 and E4, in Huis and Hans were 0.021, 0.947, 0.032 and 0.187, 0. 702, 0.112, respectively. The results showed that difference in frequencies of genotypes and alleles of Huis and Hans was very significant (both P

Objective:To observe the fluoride release rate of F-containing thermoplastic resina,trying to find a suitable concentration of fluoride in thermoplastic resina to prevent caries in base teeth of partial denture restorations.Methods:Na2(PO3)F-containing thermoplastic resina,respectively 0,10%,15%,20% and 25%(w/w)in concentration were cut into three 1 g blocks and immersed in 100,200 and 500 ml deionized water.These composite resins in 100 ml and 200 ml solutions were replaced every 1,2,3,6,9,16 days(every 7 days after that)until two months later,500 ml solution was reserved after 3,6,9 days every 7 days later until two months,2 ml of which were reserved every time.The fluoride release rates of these thermoplastic resina were tested by potentiometry.Results:All thermoplastic resina containing different concentrations of fluoride could release F-during the period of 65 days.Conclusion:When Na2(PO3)F is mixed in thermoplastic resina,it releases fluoride slowly.Thermoplastic resina containing 15% F-has higher release rates of fluoride.

Objective:To observe the efficacy and safety of docetaxel plus apatinib as a second-line treatment for advanced non-squa-mous non-small cell lung cancer. Methods:From February 2015 to August 2016, 39 eligible patients were randomly assigned to experi-mental arm (19 cases) and control arm (20 cases). Patients in the experimental arm received 60 mg/m2 d1 docetaxel and 500 mg d1-21 apatinib for a 21-day cycle until disease progression or unacceptable toxicity occurred. Patients in the control arm received chemother-apy only. Disease control rate (DCR), incidence of adverse event, and progression-free survival (PFS) were analyzed. Results:The dis-ease control rates (DCR) in the experimental and control arms were 63.2% and 30.0%, respectively, with statistical difference (P=0.039). The experimental arm experienced many grades 3-4 hematologic adverse events with statistical difference (P=0.032). The medi-an PFS values were 5.6 months (95% CI=4.8-6.3) and 3.0 months (95% CI=1.8-4.1) with statistical difference (P=0.04). Conclusion:Docetaxel plus apatinib can be delivered safely with careful monitoring for the treatment of advanced non-squamous non-small cell lung cancer, and this treatment can significantly improve the DCR and PFS.

Objective:To investigate the current situation of surrogate in China,analyze the reasons,and then provide effective suggestions and countermeasures.Methods:A questionnaire survey was conducted among medical staff and patients in an institution with assisted reproductive technology (ART),combining literature review and sociological research methods such as data maps,to explore and analyze the surrogacy.Results:The number of institutions with ART increased rapidly and its regulation became difficult.More surrogate network was observed in first-tier cities as well as the eastern and southeastern coastal provinces.That respondents agreeing with surrogacy was quite serious in some provinces.The reasons of surrogate were patients' needs,social concepts,weak government supervision,and so on.Conclusions:It should improve the laws of ART,explore long-term supervision mechanism,strengthen the management of internet,shield the information about surrogate,enhance medical ethics education for ART staff,and guide the infertility patients to establish the correct ethical concepts.

Objective:To investigate and analyze of informed consent in assisted reproductive technology ( ART) institutions, understand the status and problems.Improve the content and methods of informed consent. Methods:A questionnaire was investigated for the medical staffs and patients anonymously in ART institutions. Results:The implementation of informed consent need to be improved.Medical staffs protect the patient privacy inadequately.The patients also not pay attention to the informed consent.Medical staffs look forward to ethics training.Conclusions:The current situation of informed consent is not optimistic in ART institutions.The ethics training need to be strengthen to improve the awareness of medical staffs about informed consent.The content and methods of informed consent should be standardized,and explore the evaluation methods to enhance the effect of in-formed consent.

The pathogenesis of migraine is not fully understood as yet. Recently, with the development of ultrasonography, some stud-ies indicated that the prevalence of right-to-left shunt (RLS) seemed to be higher in migraine, especially in migraine with aura. The progress in the relationship between migraine and RLS was reviewed.