Objective: To study the diterpenes in the roots of Rabdosia japonica var. glaucocalyx. Methods: The constituents of R. japonica var. glaucocalyx were separated and purified with chromatographic methods, and their structures were elucidated by spectroscopic methods. Results: Two compounds were isolated from the roots of R. japonica var. glaucocalyx, and they were identified as glaucocalyxoside (1) and inflexuside A (2). Conclusion: Compound 1 is a new abietane diterpene glycoside named glaucocalyxoside, and compound 2 is isolated from R. japonica var. glaucocalyx for the first time.

Cardiovascular Diseases ; etiology ; prevention & control ; Humans ; Metabolic Syndrome

Cardiovascular Diseases ; prevention & control ; China ; Humans

Objective: To observe influence of aerobic exercise on blood pressure in patients with white coat hypertension (WCH). Methods: A total of 51 newly diagnostic WCH patients were randomly divided into exercise group (n=26) and WCH control group (n=25). Patients in exercise group received aerobic exercise training (walking on flat ground by constant speed, twice a day, 50~80 min each time for three months); The WCH control group did not exercise. Office blood pressure (OBP) and 24h ambulatory blood pressure monitoring (ABPM) were measured in both groups before and three months after treatment. Results: There were no significant difference in indexes of OBP and ABPM between two groups before treatment (P>0.05). After three months, compared with before treatment, indexes of OBP and ABPM significantly decreased in exercise group and they were significantly lower than those of WCH control group in OBP [OSBP: (132.54±17.60) mmHg vs. (143.68±20.35) mmHg, ODBP: (89.12±18.39) mmHg vs. (92.75±17.24) mmHg] and ABPM [ mSBP：(121.57±20.86) mmHg vs. (128.06±19.45) mmHg, mDBP：(76.24±15.28) mmHg vs. (84.55±17.31) mmHg; dSBP：(124.27±22.50) mmHg vs. (130.85±24.61) mmHg, dDBP：(77.95±18.42) mmHg vs. (82.36±17.59) mmHg], P<0.05~0.01. Conclusions: Aerobic exercise can significantly improve blood pressure in patients with white coat hypertension.

The incidence rate of hepatocellular carcinoma (HCC) is increasing around the world and tends to decrease in East Asia and several regions in China;however, China still has higher incidence rate and mortality rate of HCC than most countries.Studies have shown that long-term antiviral therapy can inhibit HBV replication to a very low level or help patients with HCV infection achieve sustained virologic response, which can further reduce the incidence rate of virus-related HCC.New evidence suggests that compared with nucleos(t)ide analogues, PEG-IFNα has a better effect of secondary prevention.Studies also indicate that interferons play an important role in tertiary prevention of virus-related HCC.This article reviews the epidemiological studies on virus-related HCC in recent years and the role of antiviral therapy in second and tertiary prevention and points out that adequate and effective antiviral therapy is the basis for preventing the development and recurrence of HCC.

Hematopoietic stem cell transplantation (HSCT) has been widely performed for patients with various genetic and acquired malignant and non-malignant diseases.Central nervous system (CNS) complications are considered an important cause of morbidity and mortality after HSCT.This review discuss the main causes of CNS after HSCT such as infection,drug toxicity,graft-versus-host disease,metabolic encephalopathy,neurologic relapses etc,so as to benefit the early recognition of CNS complications and to improve the prognosis of patients after HSCT.

Objective To explore the value of electroencephalogram (EEG) in children with headache.Methods 180 children with headache were carried out EEG recording,and the electrical activity of the brain was recorded and analyzed.Results In 180 cases of children,EEG was normal in 56 cases,abnormalities in 124 cases,the abnormal rate was 68.89％.The mild abnormalities was 78 cases,in a proportion to 43.33％ in the total record:moderate abnormalities was 14 cases,in a proportion to 7.78％ in the total reccrd;high-grede,abnormalities was 2 cases,in a proportion to 1.11％ ;5 patients was in critical state,in a proportion to 2.78％ ;epileptiform activity was 25 cases,in a proportion to 13.89％.97 normal cases with intermittent headache,abnormal rate was 46.1 1％,which was significantly lower than the attack headache ( x2 =15.16,P ＜ 0.05 ).Conclusion Headache in children with EEG examination had important significance.

Objective To observe the efficacy of the combination of moxibustion and pressing beans on auricular in the treatment of elderly patients with chronic diarrhea.Methods 45 elderly patients met the diagnostic criteria for diarrhea were divided into two groups,the treatment group (23 cases) received the treatment of combined moxibustion with ear pressure beans,the control group (22 cases) received traditional Chinese medicine treatment.The efficacy was observed and compared after two weeks.Results The effective rate reached 95.6％ in the treatment group,81.8％ in the control group (statistically significant difference,odds ratio 1.16).Conclusion Combined ear pressure beans with moxibustion treatment will receive a significant effect for the elderly patients with chronic diarrhea.The therapy is worth clinical application.

Objective To investigate the effects of losing ratio of orthodontic brackets bonding after prolonged etching time (prolonged etching time method) and microabrasion with normal acid etching time (etching after microabrasion method) to different degree of dental fluorosis.Methods A total of 30 patients with dental fluorosis were selected from the cases treated in the Department of Stomatology,Lianyungang Hospital of Traditional Chinese Medicine.They were classified as 3 groups from mild to severe degree according to Dean's criteria,10 people per group.Patients within each group were randomly assigned to 2 subgroups,5 people per subgroup;prolonged etching time method and etching after microabrasion method were used,respectively,in each subgroup.The total and first losing ratios of brackets at five time points (1,2,4,12 and 24 weeks) were observed.The losing ratio differences of orthodontic brackets between the two disposing measures bonding to different degree of dental fluorosis were analyzed.Resuts The total bracket loss rates were 38.3％ (46/120) and 21.4％ (25/117),respectively,in severe dental fluorosis disposed by prolonged etching time method and etching after microabrasion method.It was significantly higher than that of the same processing method of mild and moderate dental fluorosis groups,in which the total bracket loss rates were 12.5％ (15/120),18.1％ (21/116),7.6％ (9/118) and 5.8％ (7/120),respectively,and the differences were statistically significant (x2 =21.12,11.87,8.96,12.24,all P ＜ 0.01).The total loss rate of etching after microabrasion method was lower than that of prolonged etching time method in mild dental fluorosis group,the difference was not statistically significant (x2 =1.56,P ＞ 0.05).The total loss rates of etching after microabrasion method were lower than that of prolonged etching time method in moderate and severe dental fluorosis groups,and the differences were statistically significant (x2 =8.49,8.13,all P ＜ 0.05).The medians of first bracket loss rates were 8.3％ and 4.3％,respectively,in severe dental fluorosis disposed by prolonged etching time method and etching after microabrasion method.They were significantly higher than that of the same processing method of mild and moderate dental fluorosis groups,in which the medians of first bracket loss rates were 2.5％,4.3％,1.7％ and 0.8％,respectively,and the differences were statistically significant (U =2.619,2.627,2.312,2.627,all P ＜ 0.05).The average percentage of first bracket loss rates of etching after microabrasion method was lower than that of prolonged etching time method in mild dental fluorosis group,the difference was not statistically significant (U =-0.949,P ＞ 0.05).The average percentages of first bracket loss rates of etching after microabrasion method were lower than those of prolonged etching time method in moderate and severe dental fluorosis groups,and the differences were statistically significant (U =-2.214,-2.410,all P＜ 0.05).Conclusions Whether in prolonged etching time method subgroup or etching after microabrasion method subgroup,the more serious injury of dental fluorosis is,the higher loss rate of orthodontic bracket will be.For the clinical treatment of mild and severe dental fluorosis,the effect of etching after microabrasion method is better than prolonging etching time method.