Several models about epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)as first-line treatment in advanced NSCLC show different results.Combination with chemotherapy and EG-FR-TKIs did not indicate survival advantage.However,sequential chemotherapy in EGFR-TKIs and a single agent of EGFR-TKIs as first-line treatment of advanced NSCLC have made tremendous breakthrough,and give a new path in individual treatment of advanced NSCLC.Also EGFR mulatious in targeted therapy of advanced NSCLc has a sood predictive value of the etticacy.

A backup data center near the primary data center using Storage Area Network is built with Fiber Channel technology. The specific disaster recovery software used to synchronize the two centers a highly reliable safety and expandable data storage management system with adequate redundancy is developed. Thus disaster recovery service can be provided for the hospital information system when disaster happens. To avoid the system risk and maintain the continuity of the hospital's activities the damaged part of the system will be taken over from.

AIM: To develop a method of determining notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 in Naomaitai Capsules(Radix et Rhizoma Ginseng Rubra,Radix et Rhizoma Notoginseng,Radix Angelicae Sinensis,etc.) by HPLC. METHODS: Notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 were determined by HPLC gradient elution method,Inertsil-ODS-3(5 ?m 4.6 mm?250 mm) column with Acetonitrile-water as the mobile phase was used for gradient elution.The flow rate was at 1.0 mL/min and the detective wavelength was at 203 nm.The column temperature was at 35 ℃. RESULTS: There was a good linear relationship at a range of 0.205-1.539 ?g for notoginsenoside R_1(r=0.999 6),the average recovery of 98.07%, and RSD of 0.51%(n=5),0.838-6.285 ?g for ginsenoside Rg_1(r=0.999 4),the average recovery of 97.66%,and RSD of(0.53%)(n=5),0.822-6.165 ?g for ginsenoside Rb_1(r=0.999 6),the average recovery of 98.19%,and RSD of 0.44%(n=5). CONCLUSION: The method is simple,reproducible and accurate with a strong specificify,and can be used for the quality control of Naomaitai Capsules.

AIM:To establish the quality standards for Qinghuo Tablets(Folium Isatidis,Radix et Rhizoma Rhei,Gypsum Fibrosum,etc.). METHODS:Folium Isatidis,Radix et Rhizoma Rhei,menthol in Qinghuo Tablets were identified by TLC.Indirubin and emodin were determined by HPLC.Agilent-ODS-3(5 ?m,4.6 mm?250 mm) column was used.The column temperature was at 25 ℃.Methanol-0.5% H_3PO_4(75∶25) was used as a mobile phase.The detection wavelength was at 289 nm.The flow rate was 1.0 mL/min. RESULTS:Folium Isatidis,Radix et Rhizoma Rhei,menthol could be detected by TLC.Indirubin showed a good linear relationship at the range of 0.071 4-0.714 ?g,r=0.999 7.The average recovery was 98.95%,and RSD was 0.57%.Emodin showed a good linear relationship at the range of 0.204-2.04 ?g,r=0.999 8.The average recovery was(99.01%),and RSD was 0.79%. CONCLUSION:The established method is rapid,accurate,reproducible with a strong specificify.

Objective To explore the relationship between heart rate variability(HRV)and serum high sensitivity C-reactive protein(hs-CRP)in type 2 diabetic aged patients.Methods Totally 30 aged patients with type 2 DM were enrolled in this study who were selected from the outpatients and inpatients of Department of Gerontology in the Third People's Hospital of Chongqing,and another 30 non-diabetic matched individuals were recruited as control.Their serum hs-CRP and 24 hour-electrocardiography were examined.HRV was assessed by calculating the indices based on statistical operation on RR intervals(time domain analysis)from 24-hour Holter recording,including:standard deviation of normal to normal RR intervals(SDNN),standard deviation of 5-minute mean RR intervals(SDANN)and square root of differences between adjacent NN intervals(rMSSD).Linear correlation analysis was carried out between their serum hs-CRP and HRV.Results HRV parameters of type 2 DM patients were significantly lower than those of non-diabetic patients,but hs-CRP values were significantly higher than those of control.Linear correlation analysis indicated that HRV was in a positive correlation with hs-CRP in type 2 diabetic aged patients.Conclusion Altered autonomic nervous function may be associated with altered serum hs-CRP in aged patients with type 2 diabetes mellitus.

Far beyond simulating manual work with the computer system,hospital informatization entails a combination of information technology with hospital professional work.With a fully understanding of working procedure in hospital,an effective concordance based on informatization requirements is conducted so that the management and the collection of the information can follow the information flow,logistics,capital flow,working flow and organization flow.Management mode and organization framework of the hospital are also adjusted.Thus the hospital operation quality and efficiency are improved,and patients are offered seamless and continuous service,which really reflects the service theory: "Patient First".

Adult ; Citric Acid ; adverse effects ; Dust ; Humans ; Male ; Middle Aged ; Occupational Exposure ; adverse effects ; Tooth Erosion ; chemically induced

Atrial fibrillation is the most common arrhythmia in clinical practice.However,the therapeutic effects of traditional antiarrhythmic medicines are far from satisfactory,because of the high rate of arrhythmia recurrence and the potential proarrhythmia effect.Recently,with the further investigation of the mechanisms that initiate and perpetuate atrial fibrillation,and the support of extensive data from clinical trials and animal experiments,thera-peutics based on anti-inflammation,antioxidation,regulation on renin-angiotensin-aldosterone system(RAAS)and gap junction may be new therapeutic targets for the treatment of arrhythmia.In this paper,the potential molecular mechanisms involved in these processes and several clinical trials about some non-traditional antiarrhythmic medi-cines were reviewed,in order to propose a new idea about the development of antiarrhythmic medicines.

Objective To investigate clinical effects and safety difference of cholesterol absorption inhibitor associated with atorvastatin for high dose on elderly patients with coronary heart disease and poor lipid controlling. Methods 240 elderly patients with coronary heart disease and poor lipid controlling were chosen and randomly divided into 3 groups including group A (80 patients)with atorvastatin for conventional dose,group B (80 patients)with atorvastatin for high dose and group C (80 patients)with atorvastatin for high dose associated with ezetimibe for cholesterol absorption inhibitor;and the compliance rate of total cholesterol (TC)and low density lipoprotein cholesterol (LDL-C),serum lipids before and after treatment and the incidence of adverse reaction of 3 groups were compared. Results The compliance rate of TC of group A,group B and group C were separately 40.00%(32/80),62.50%(50/80)and 96.25%(77/80);the compliance rate of LDL-C of group A,group B and group C were separately 51.25%(41/80),81.25%(65/80)and 98.75%(79/80);the compliance rate of TC and LDL-C of group C was significant better than that of group A and group B (χ2 =58.28,27.83,48.13,13.61,all P<0.05).The levels of TC,TG,LDL-C and HDL-C of group A after treatment were separately (5.35 ±1.26)mmol/L,(2.10 ±0.83) mmol/L,(2.85 ±0.93)mmol/L and (1.23 ±0.67)mmol/L;the levels of TC,TG,LDL-C and HDL-C of group B after treatment were separately (4.97 ±1.02)mmol/L,(2.05 ±0.81)mmol/L,(2.47 ±0.86)mmol/L and (1.20 ± 0.65)mmol/L;the levels of TC,TG,LDL -C and HDL -C of C group after treatment were separately (3.84 ± 0.82)mmol/L,(1.74 ±0.56)mmol/L,(2.06 ±0.71)mmol/L and (1.24 ±0.52)mmol/L.The levels of TC,TG and LDL-C of group C after treatment was significant better than group A and group B (F=3.80,4.94,4.21,all P<0.05).There was no significant difference in level of HDL-C among 3 groups after treatment(P>0.05).The incidences of adverse reaction of group A,group B and group C were separately 1.25%(1/80),3.75%(3/80)and 2.50%(2/80);there was no significant difference in incidence of adverse reaction among 3 groups(χ2 =1.03,P>0.05).Conclusion Cholesterol absorption inhibitor associated with atorvastatin for high dose on elderly patients with coronary heart disease and poor lipid controlling can efficiently control blood lipid levels,improve compliance rate of blood lipids,and did not increase the risk of adverse reaction.

Twenty-nine cases of postherpetic neuralgia of herpes zoster were treated by the surround needling with electric stimulation, and the better therapeutic effect was obtained, the total effective rate was 93.1%.