1.Preliminary application of 3D printing to manufacture a customized guide plate for clinical percutaneous needling at the hip joint
Teng LIU ; Li SUN ; Quan WU ; Jin ZHANG ; Qin YANG ; Geng TANG ; Xiaobin TIAN
Chinese Journal of Orthopaedic Trauma 2016;18(5):381-385
Objective To investigate the safety and efficacy of a customized guide plate which is designed by digital medical technology and manufactured by 3D printing in clinical percutaneous needling at the hip joint.Methods Enrolled in this study were 9 patients with hip disorder who required hip joint needling during the period from April 2015 to August 2015.They were 7 males and 2 females,21 to 53 years of age (average,42 years).Laterality:5 left sides and 4 right sides.Conditions:4 cases of traumatic arthritis and 5 cases of osteoarthritis.All of them underwent lamellar CT scans whose data were imported into the software of Mimics 10.01 for 3D reconstruction.Then the software of 3-matic was used to design a customized guide plate on the reconstructed models.Finally,3D printing was used to manufacture the guide plate.The needle angle,direction and depth were adjusted in vitro and the operation was simulated before actual needling in clinic.After percutaneous hip joint needling was performed in the 9 patients separately,the accuracy of needling was checked using C-arm fluoroscopy.Results The percutaneous hip joint needling was performed successfully in the 9 patients in whom the customized guide plate was used.The results were consistent with what had been designed on the reconstructed models.The operation time in the 9 patients averaged 417.7 s (range,from 387 s to 590 s).Little intraoperative bleeding was observed at the site of needling,fluoroscopy was applied only once for check.No neurovascular injury or other operation-related complications occurred.Conclusion For patients who need repeated percutaneous needling at the hip joint,the customized guide plate designed by us can improve accuracy and ensure safety and efficacy of needling.
2.Reducing radiation dose with electrocardiogram-pulsing technique in 64-row multi-slice spiral CT coronary angiography
Min WU ; Ming YANG ; Jiyang JIN ; Gangcai ZHONG ; Zhi QIN ; Jie FAN ; Lingling LI ; Gaojun TENG
Chinese Journal of Radiology 2009;43(7):693-696
Objective To evaluate the value of reducing radiation dose with ECG-pulsing and image quality in 64-row multi-alice CT coronary angiography.Methods Fifty-nine consecutive patients whose heart rates were less than 80 beat per minute and cardiac rhythm was regular were randomly divided into two groups from October 26, 2007 to March 12, 2008.Conventional technique of CT coronary angiography was employed in group 1, while ECG-pulsing technique was applied in group 2.CT dose index volume (CTDIvol) and dose length product (DLP) were obtained automatically, and then the corresponding effective dose (ED) were calculated.The quality scores were performed on obtained imaging by using double blind method.Student t-test was applied in the comparison of value of CTDIvol, value of ED and quality of imagiugbetween two groups.Results The value of CTDIvol was (70.0±1.1) and (39.0±2.7) mGy, the value of ED was (16.8±2.0) and (9.5±1.7) rosy in group 1 and group 2, respectively, which reached statistically significant differences between the groups(t=57.675,15.346 ,P <0.01, respectively). The quality scores of coronary images were 3.8±0.2 and 3.8±0.1 in the groups, which did not reach the statistical significance (t=-0.222, P 0.05).Conclusions The proper application of ECG-Pulsing technology in 64-slice spiral CT coronary angiography can reduce radiation dose significantly while having no influence on the quality of the imaging.
3.Study on corrosion resistance of three non-noble porcelain alloys.
Zhikai WU ; Sheng XU ; Wei LI ; Jin TENG ; Ning LI
West China Journal of Stomatology 2011;29(5):485-493
OBJECTIVETo study the electrochemical corrosion behavior of Co-Cr, Ni-Cr and Ni-Cr-Be based porcelain alloys in NaCl solution.
METHODSFive samples of each alloy were made respectively, electric polarization curve of each alloy was obtained using potentiodynamic polarization technique. Self-corrosion potential (E(corr)), self-corrosion current density (I(corr), passive region and transpassivation potential were tested. Microstructure and constituent was examined using scanning electron microscopy and energy dispersive spectroscopy.
RESULTSCo-Cr alloy possessed the most desirable corrosion resistance because of its integrated, homogeneous and compact passive film. The poor compactness of Ni-Cr alloy's passive film decreased its corrosion resistance. Ni-Cr-Be alloy exhibited the worst corrosion resistance due to the Cr and Mo depleted Ni-Be eutectic phases in the alloy.
CONCLUSIONTaking biological security into consideration, it is necessary to avoid the application of porcelain alloys with Be element. Co-Cr alloy with better biocompatibility possesses much broader prospect in the field of dental restoration.
Alloys ; Chromium Alloys ; Corrosion ; Dental Alloys ; Dental Porcelain ; Microscopy, Electron, Scanning ; Nickel ; Surface Properties
4.Changes in distribution and antimicrobial resistance of pathogens causing bloodstream infection in 2012-2015
fei Teng XU ; wu Zhi LIU ; ling Feng JIN
Chinese Journal of Infection Control 2017;16(10):936-940
Objective To investigate the changes in distribution and antimicrobial resistance of pathogens causing bloodstream infection in a hospital in 2012-2015.Methods Pathogenic bacteria isolated from blood culture in a hospital microbiology laboratory between January 2012 and December 2015 were collected and divided into 2012-2013 group and 2014-2015 group,distribution characteristics,constitute,and antimicrobial susceptibility of two groups were compared.Results Gram-negative bacteria were the main pathogens isolated during two periods,ac-counting for 54.96% and 54.66% respectively,there was no significant differences in pathogen distribution between two groups (P >0.05).Gram-positive cocci had a high sensitivity to vancomycin and linezolid,resistant rates were both 0;resistance rates of coagulase negative staphylococci to oxacillin were all >80%,resistance to penicillin was also >90%;Enterobacteriaceae was highly sensitive to imipenem and meropenem,but resistance strains had ap-peared;Acinetobacter baumannii was sensitive to minocycline during two periods,resistance rates were 35.90% and 34.55% respectively,resistance rates to other antimicrobial agents were also high (>75%).Conclusion The iso-lation rate of drug-resistant pathogenic strains causing bloodstream infection is high,monitoring on bacterial resistance is helpful for guiding rational use of antimicrobial agents in clinic.
5.The clinical significance of the change of plasma BNP levels in patients with grades sepsis
Ling TENG ; Yinghe XU ; Zhencang ZHENG ; Yi JIN ; Qingxin SHI ; Cheng YANG ; Aixiang YANG ; Huijuan WU ; Peng CHEN
Journal of Chinese Physician 2011;13(2):184-187
Objective To study the clinical significance of the change of plasma BNP levels in patients with grades sepsis and its correlation with the left ventricular ejection fraction.Methods One hundred patients of sepsis who were admitted in intensive care unit of Taizhou hospital were selected.It was divided into four groups:30 patients with septic shock,40 patients with severe sepsis,30 patients with sepsis and 20 persons without disease as control group.The concentration of plasma BNP was determined using sandwich immunoflurescence,and ultrasonic cardiogram was used to evaluate heart function and clinical features in all groups.To compare with the differences of the concentration of plasma BNP and the correlation between the concentration of Plasma BNP and LVEF in all groups,the data of clinical features,28-day mortality,prognostic values of BNP and the length of stay (ROG) in ICU were collected and compared.Result Plasma BNP levels in patients with septic shock[ (976.3 ± 160.7) pg/ml] were obvious higher than severe sepsis[ (648.4 ± 267.3) pg/ml ],sepsis [ (217.2 ± 89.7) pg/ml ] and control group [ (50.3 ± 25.4)pg/ml] (P <0.01).LVEF in patients with septic shock [ (48.2 ±9.6)% ] was obvious lower than severe sepsis[ (52.8 ±9.4)% ],sepsis[ (61.3 ± 8.9)% ] and control group[ (66.4 ±9.3)% ] (P <0.05 or P <0.01).It appeared to be inverse relationship between LVEF and the plasma BNP levels (r =-0.876,-0.724,P <0.01).BNP levels were significantly higher in non-survivors compared with survivors[ (1367.6±506.4)pg/ml vs (420.3 ±82.6)pg/ml,P <0.01 ].The receiver operating characteristic (ROG) curves indicated that values of areas under the curve of plasma BNP levels for 28-days mortality were 0.918(P <0.01).Conclusion The concentration of plasma BNP in patients was different in different grades of sepsis.It appeared to be negative correlation between the concentration of plasma BNP and LVEF.Plasma BNP levels had predictive value to the patients with sepsis.
6. Prenatal diagnosis for 30 women carrying a FMR1 mutation
Wen HUANG ; Jin XUE ; Huaixing KANG ; Xinxin GUAN ; Yanling TENG ; Lingqian WU ; Ranhui DUAN
Chinese Journal of Medical Genetics 2019;36(9):866-869
Objective:
To determine the CGG repeat number and methylation status of FMR1 gene for fetuses whose mothers have carried a
7.The effect of satir model for compulsory drug rehabilitation women
Yeping LI ; Juan WU ; Mingxing DENG ; Xia ZHANG ; Jin PAN ; Xingming SHI ; Kecheng WEI ; Longbiao XU ; Lihong ZHOU ; Yongsheng TENG ; Hua LI
Chinese Journal of Primary Medicine and Pharmacy 2011;18(13):1766-1767
Objective To explore the feasibility and validity of Satir model on compulsory drug rehabilitation for female drug users in closed settings. Methods Satir Model-based group psychotherapy was adopted in the treatment on 33 female drug users. Results The findings are that the pre-treatment SCL-90 scores were all higher than norm,indicating very high significant differences(P<0.01) ; while the post-treatment SCL-90 scores,except the score of somatization, were approximate to norm, showing no statistical differences(P >0. 05). Conclusion Satir model played a positive role in the process of female drug users mental health recovery.
8.MRI with necrosis-avid contrast agent for the assessment of myocardial viability in a swine model
Ji-Yang JIN ; Gao-Jun TENG ; Yi FENG ; Yan-Ping WU ; Qin-Di JIN ; Yu WANG ; Qin LU ; Zhen WANG ; Xiao-Guo ZHANG ; Sheng-Qi WANG ; Feng CHEN ; Yicheng NI ;
Chinese Journal of Radiology 2001;0(08):-
0.05).There was excellent correlation between the lesion size on EC Ⅲ-60 enhanced T_1-weighted MR images and histomorphometry(r=0.999,P
9.Expression of prostate cancer antigen-1 in prostate cancer and its clinical significance.
Bing-qian LIU ; Yu-dong WU ; Jin-xing WEI ; Tong ZHANG ; Ran-lu LIU ; Teng-xiang MA
National Journal of Andrology 2007;13(11):997-1001
OBJECTIVETo investigate the expression of prostate cancer antigen-1 (PCA-1) in different prostate tissues and analyze its correlation with the clinical parameters of prostate cancer (PCa).
METHODSThe expression of PCA-1 mRNA was detected by RT-PCR in the samples from 45 cases of PCa with various clinico-pathologic characteristics, 30 cases of high-grade prostatic intraepithelial neoplasia (HG-PIN), 43 cases of BPH and 39 cases of other carcinoma tissues. The correlation of PCA-1 mRNA expression with the clinical parameters of PCa was statistically analyzed and the PCA-1 expression was examined in different samples by immunohistochemistry.
RESULTSThe positive expression rate of PCA-1 mRNA was 88.9% and 60.0% and that of PCA-1 protein was 84.4% and 50.0% in the patients with PCa and HG-PIN, respectively. PCA-1 mRNA and PCA-1 proteins were not expressed in the BPH and other carcinoma tissues. The expression of PCA-1 mRNA was unrelated with the clinical parameters of PCa (P > 0.05).
CONCLUSIONIt is suggested that PCA-1 is a PCa-specific gene and its expression is unrelated to the clinical parameters of PCa. It might serve as a specific biomarker for the early diagnosis of PCa.
Aged ; Aged, 80 and over ; Gene Expression Regulation, Neoplastic ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Prostate-Specific Antigen ; biosynthesis ; genetics ; Prostatic Neoplasms ; genetics ; metabolism ; pathology ; RNA, Messenger ; genetics ; metabolism ; Reverse Transcriptase Polymerase Chain Reaction
10.Surgical management of craniomaxillofacial fibrous dysplasia.
Guo-Ping WU ; Li TENG ; Lai GUI ; Zhi-Yong ZHANG ; Feng NIU ; Chang-Sheng LÜ ; De-Lin XIA ; Jin-Chao LUO ; Bing YU
Chinese Journal of Plastic Surgery 2005;21(5):338-341
OBJECTIVETo explore the method to obtain good aesthetic and functional results in surgical management of craniomaxillofacial fibrous dysplasia and correct the grotesque deformity.
METHODSAccording to the type of the lesions, different excision and reconstruction methods were used.
RESULTS19 cases (4 monostotic cases and 15 polyostotic cases) were surgically treated. The period of follow-up range from 9 months to 5 years, all patients obtained satisfactory aesthetic and functional results. No relapse happened during follow up.
CONCLUSIONSBased on modern craniomaxillofacial techniques and computer aided design, extensive radical excision and craniomaxillofacial skeleton reconstruction could be safely accomplished, and the better results were obtained, both aestheticly and functionally.
Adolescent ; Adult ; Bone Transplantation ; Child ; Computer-Aided Design ; Craniofacial Abnormalities ; surgery ; Facial Bones ; Female ; Fibrous Dysplasia of Bone ; surgery ; Follow-Up Studies ; Humans ; Male ; Reconstructive Surgical Procedures ; Skull ; Surgical Flaps ; Young Adult