Objective To explore the influence and potential protective effects of non-specific panMetrix Metalloproteinases(MMPs) inhibitor Doxycycline on hyperoxic lung injury and lung development in neonatal rats.Methods Neonatal SD rats were divided into 4 groups randomly within 12 hours after birth:air with normal saline(AN),air with doxycycline(AD),hyperoxia with normal saline(ON),and hyperoxia with doxycycline group(OD).Hyperoxia groups(ON and OD) were exposed to ≥90% O2.Doxycycline 20 mg/kg or equal volume of 0.9% saline(Doxycycline concentration 2 mg/ml) was administered by gastric gavage,twice daily from day 1 to experimental day,but it didn't exceed 14 days.Stereological study was carried out at day 1,3,7,14 and 21 after birth.Results Enlarged mean alveolar area was noted both in hyperoxia and Doxycycline groups.OD group had larger star volume than ON group on day 14.Except ON group,all other groups had increased alveolar septum and the condition was worsened by hyperoxia with Doxycycline.The percentage of collagen in lung parenchymal tissue in ON group increased persistently.This increasing trend was stopped in OD group on day 14,and collagen percentage had no significantly difference between OD and AN groups on day 14 and 21.Conclusion Both hyperoxia and Doxycycline influence neonatal lung development,percentage of coUgen in lung parenchymai can be reduced by Doxycycline in hyperoxic lung injury.

[ABSTRACT]IL-13isapleiotropiccytokinemainlysecretedbyactivatedTh2cells.Ithas2receptors,IL-13Rα1 and IL-13Rα2.The latter had been thought to serve exclusively as a decoy receptor for a long period of time due to its short cytoplasmic tail and lack of signal transduction structure .Since Fichtner-Feigl reported in Nature Medicine that IL-13 is in-volved in induction of TGF-βproduction and tissue fibrosis through IL-13Rα2-mediated signaling pathway , it was found that IL-13Rα2 has more sophisticated functions than just a simple decoy receptor as more and more researches have explored its signaling functions .This review combines the most advanced research results with previous investigation and discusses the gene structure, expression, production, distribution, subtype conversion and possible signal pathways mediated by this re-ceptor.More importantly, the connection with human diseases and the applications in disease diagnosis and molecule targe -ted therapy for cancer are also discussed .

Objective To determine the expression of Aquaporin 8 (AQP8) in the fetal membrane and placenta of idiopathic polyhydramnios. Methods The amnion, chorion and placenta were collected from 12 term pregnancies with idiopathic polyhydramnios(polyhydramnios group) and 12 term pregnancies who were normal (control group). The expression of AQP8 mRNA was detected by reverse transcription-polymerase chain reaction (RT-PCR). The expression of AQP8 protein was detected by immunohistochemistry. Results The expression of AQP8 mRNA in amnion, chorion and placenta of polyhydramnios group was (0.78±0.13), (0.58±0.10), and (0.86±0.15) respectively, and that of control group was (0.39±0.07 ), (0.45±0.09),and (0.34±0.09) respectively. The expression of AQP8 protein in amnion, chorion and placenta of polyhydramnios group was (0.195±0.024), (0. 170±0.028), and (0. 193±0.024) respectively, and that of control group was (0. 151±0.018), (0.156±0.024), and (0. 152±0.023) respectively. In all 3 types of tissues the expression of AQP8 mRNA of polyhydramnios group was higher than that of control group (P<0.05). In anmion and placenta the expression of AQP8 protein of polyhydramnios group was also increased compared to that of control group (P<0.05), but in chorion the difference in AQP8 protein expression between the two groups was not significant(P>0.05). Conclusion The expression of AQP8 mRNA and protein is significantly increased in the anmion and placenta of polyhydramnios, suggesting that AQP8 may play an important role in the regulation of amniotic fluid volume.

Objective To evaluate the curative effect of ilio-inguinal and Kocher-Langenbeck (K-L) approach internal fixation and reduction in the treatment of acetabular fractures in a floppy lateral position.Methods A retrospective study was done on 31 patients treated from February 2005 to March 2009,including 15 patients with complex acetabular fractures treated with ilio-inguinal and K-L approach internal fixation and reduction in a floppy lateral position ( Group A) and 16 patients with complex acetabular fractures treated with anterior ilio-inguinal approach and posterior K-L approach internal fixation and successive reduction in a floppy lateral position Group B).Operation time,intra-operative blood loss,number of X-ray fluoroscopy times,degree of postoperative reduction,results of Merled' Aubigne and Postel scores as well as the rate of postoperative complications were recorded.Results All the patients were followed up for 15-27 months.In Groups A and B,the operation time was for ( 176 ± 17 ) minutes and ( 196 ± 23 ) minutes ( P ＜ 0.05 ),the intra-operative blood loss for ( 880 ± 16) ml and (874 ± 19) ml (P＞0.05),the number of X-ray fluoroscopy times for 6 ±2 and 14 ±6 respectively ( P ＜ 0.05 ).According to Mata analysis standard,the postoperative fracture reduction was anatomical in 11 patients (73％),good in three and poor in one in Group A; while the postoperative fracture reduction was anatomic in nine patients 56％ ),good in five and poor in two in Group B.The rate of anatomical reduction between the two groups had statistical difference (t =2.731,P ＜ 0.05 ).The modified Merled' Aubigne and Postel score system showed excellence rate of joint function of 93％ ( 14/15 ) in Group A and 75％ (12/16) in Group B,with statistical difference ( x2 =15.292,P ＜ 0.05).There was no statistical difference in the aspect of postoperative complications between the two groups,such as heterotopic ossification,traumatic arthritis,avascular necrosis of the femoral head,nerve injury and so on.Conclusions In a floppy lateral position,combined ilio-inguinal and K-L approach internal fixation and reduction takes advantages of sufficient exposure,good reduction,strong fixation,short operation time and few complications in the treatment of certain complex acetabular fractures,while its long-term effects are worthy of further clinical researches.

Objective To compare the clinical effect of different treatment methods for the patients with great saphenous vein varicosity.Methods 140 patients with great saphenous varicose veins were selected,and according to random number table method they were divided into observation group and control group,70 cases in each group.The control group was given conventional stripped surgery,the observation group adopted high ligation joint int-racavitary laser treatment.The clinical effects of the two groups were compared.Results The operating time,intraop-erative blood loss,postoperative length of hospital stay,postoperative recurrence rate of the observation group were (51.32 ±4.97)min,(40.03 ±9.67)mL,(6.77 ±1.14)days,4.29%,respectively,which of the control group were (72.45 ±8.79)min,(108.68 ±17.75)mL,(11.69 ±2.68)days,20.00%,there were statistically significant differ-ences between the two groups(t =17.507,28.415,14.134,χ2 =8.101,all P <0.05).The incidence rate of postop-erative complications of the observation group was 4.29%,which of the control group was 14.29%,there was statisti-cally significant difference between the two groups(χ2 =4.155,P <0.05).The intervention pain score,the quality of life score of the observation group were (1.46 ±0.54)points,(90.04 ±9.77)points,which of the control group were (2.67 ±1.15)points,(78.61 ±6.82)points,there were statistically significant differences between the two groups (t =7.968,8.026,all P <0.05).Conclusion High ligation joint intracavitary laser in the treatment of great saphe-nous varicose veins is superior to the traditional operation method in operation time,intraoperative hemorrhage,length of hospital stay,and complications,and it can effectively relieve patients'pain and improve the quality of life.

Studying of atherosclerosis is more than a hundred year.There are many theories about this disease,but now most of us seems to agree with the stress-reponse theory.Heat shock proteins are the products produced at the first stage of atherosclerosis.And someone think that it may have something to do with atherosclerosis.This paper discussed the heat shock proteins and atherosclerosis respectively,and emphasized the relationship between them.

0.05).Conclusion The rat model of liver-Qi stagnation can be induced by chronic stress,which is different from the syndromes of deficiency of both heart and spleen and the interior disturbance of phlegm-heat.

Objective To investigate the methods for EGG data compression and accurate QRS detection. Methods The quick fitting of LADT was improved and the combination of the improved quick fitting of LADT and neural network was used for the detection of the location of the QRS complex. Results Test by the MIT/BIH arrhythmia database revealed high accuracy rate of QRS detection and easy real time application. Conclusion The purposes of accurate detection of QRS with a little time are realized.

Objective To explore the primary treatment of type 2 diabetes, clinical effect of rosiglitazone combined with metformin treatment.Methods In 40 patients with type 2 diabetes mellitus patients implementation of routine treatment for metformin, and 40 patients in the control group based on the use of rosiglitazone intervention treatment, two groups of patients in our hospital from January 2015 to December 2016 were compared between the two groups.Results Treatment efficiency, obvious effective rate of observation group were higher in the observation group was 95%, while only 82.5% of the control group,comparison between groups showed significant differences(P<0.05);the two groups of patients with fasting blood glucose levels, 2 hour postprandial blood glucose level There were no significant difference before treatment, after treatment group observation group significantly improved, comparison between groups showed significant differences(P<0.05).Conclusion Rosiglitazone Combined with metformin in newly diagnosed type 2 diabetes clinical observation, which can help to improve the clinical symptoms of patients, reduce blood glucose, compared with pure medication.To improve the treatment effect, it is worthy of reference.

In October 2020, the American Heart Association(AHA) published the 2020 guidelines for cardio-pulmonary resuscitation and emergency cardiopulmonary resuscitatio, it is a comprehensive revision for adult, pediatric, neonatal, resuscitation education science, and systems of care topics.This article mainly interprets the most important updates of pediatric and neonatal basic and advanced life support.