Humans ; Rectal Neoplasms ; therapy

Colorectal Neoplasms ; diagnosis ; surgery ; Humans ; Neoplasm Staging ; Preoperative Care

Humans ; Lymph Node Excision ; Neoplasm Staging ; Rectal Neoplasms ; pathology ; surgery

Insufficient treatment and overtreatment in the management of colorectal cancer greatly influence patients' outcome. The clinicopathological stage of carcinoma located in colon and rectum is different for anatomical differences. The indication of adjuvant chemotherapy varies in colon or rectal cancer. Locally advanced rectal cancer should receive neoadjuvant treatment, however, the optimal regimen is still controversial.
Colorectal Neoplasms ; therapy ; Humans ; Neoadjuvant Therapy

With the development of national economics,colorectal cancer is a life-threatening malignancy and its incidence is increasing.In recent years,based on improvements of treatment concepts,medicine and surgical techniques,the treatment mode of colorectal cancer has turned from simple surgical resection to muhidisciplinary comprehensive treatment focused on surgery and combined chemoradiotherapy with targeted medicine.At present,there is a big gap in treatment of colorectal cancer between China and advanced world levels,and the differences of medical level exist in different domestic areas.Promotion of diagnosis and treatment of colorectal cancer and improvement of efficacy on colorectal cancer are imperative.

Currently,specialized treatment for diseases is increasingly becoming the mainstream in clinical practice.Gastrointestinal surgery,as an important branch of general surgery,has increasingly developed specialized; however,our present gastrointestinal surgeon training system is not yet perfect.The article summarized the problems and challenges in gastrointestinal surgeon training in China based on the situations at home and abroad,and addressed some available gastrointestinal surgeon training protocols in future.We hope this article can be helpful on our country's gastrointestinal surgeon professional training.

Gastrointestinal cancers include gastric cancer, small intestinal cancer and colorectal cancer. In China, the majority of hospitals at central cities even at county hospitals are providing surgical intervention for patients with gastrointestinal cancer. However, the complications after gastrointestinal cancer surgery pose significant burden to the patients and their relatives because of increased hospital cost and law suit. Acute bleeding, obstruction, anastomotic leakage are major complications after gastrointestinal surgery. Therefore it is important to deal with complications after gastrointestinal surgery.
Digestive System Surgical Procedures ; adverse effects ; Gastrointestinal Neoplasms ; surgery ; Humans ; Postoperative Complications ; prevention & control ; therapy

Surgeon is sacred career. To cure patients by surgery is the surgeon's work, while the social responsibility is the surgeon's soul. To strengthen and promote the social responsibility is a demand of our age; thus, every surgeon should adhere to the supremacy of the patients' interests in clinical practice.
General Surgery ; Humans ; Physicians ; Social Responsibility

Objective To investigate the expressions of CXC chemokine receptor 3 (CXCR3) and CD1a in skin lesions of different stages of mycosis fungoides (MF). Methods The expression and distribution profiles of CD1a and CXCR3 were detected by immunohistochemistry in the epidermis of skin samples from 16 normal human controls, 16 patients with non-tumor (patch/plaque) stage MF and 8 patients with tumor stage MF. Results With the progression of MF from patch/plaque stage to tumor stage, the positivity rate of CXCR3 in intraepithelial neoplastic cells in lesions dropped from 38.9% to 17.5% (P ＜ 0.05). The average number of intraepithelial Langerhans cells (LCs) per high power field (HPF) in skin samples was 10.6 in patch/plaque stage MF, significantly higher than that in normal control (7.3) and tumor stage MF (6.7), while no significant difference was found between normal control and tumor stage MF specimens. Conclusion The epidermotropism in MF may be associated with the expression of T-helper (Th) 1-associated chemokine receptor (CXCR3) and quantity of intraepithelial LCs.

Anal Canal ; surgery ; Early Diagnosis ; Follow-Up Studies ; Humans ; Neoplasm Staging ; Rectal Neoplasms ; diagnosis ; pathology ; surgery