Objective To observe the therapeutic effect of LongXueJieJiaoNang,a compound TCM preparation,on AIDS cases complicated with peripheral neuropathy.Methods Randomized double blind and double center prospective study was conducted for 62 AIDS cases which were divided into two groups: group A with 0.6g LongXueJieJiaoNang t i.d.,and group B with 0.5g inositol,t.i.d,for 2 months(60 days),and then the therapeutic effects were compared between the 2 groups.Results The symptoms,right common peroneal nerve sensory conduction velocity(RSCV),palmesthetic threshold were improved in the two groups with the group A better than the gtoup B(the rates of improvement were 78.0% and 48.4%、66.1% and 30.6%、67.7% and 48.4%,respectively).The total effective rate was 74.4% in group A and 37.5% in group B.Conclusion LongXueJieJiaoNang is effective for AIDS cases complicated with peripheral neuropathy.

Hedgehog(Hh) pathway plays a key role in a variety of processes, such as embryogenesis, maintenance of tissue homeostasis, tissue repair and carcinogenesis. Recent studies indicate that the aberrant activation of Hh pathway has been linked to multiple types of human cancer. Here, we present an overview of the processing and secretion of Hh pathway and the role of Hh pathway in gastric cancer.

Gastric cancer is one of the most common malignant tumors.Over recent years,the development of new genetic technologies have built the foundation for a better understanding of the abnormal expression of miRNAs in gastric cancer.It might improve the accuracy of prognosis prediction and lead to more efficient personalized treatments for gastric cancer.The article will review the potential applications of miRNAs as biomarkers for mechanism,diagnosis and prognosis of gastric cancer.

Objective To observe clinical efficacy of osteoporotic thoracolumbar compression fractures treated by manual reduction with percutaneous vertebroplasty. Methods Totally 82 patients with osteoporotic thoracolumbar compression fractures were randomly divided into treatment group (43 cases) and control group (39 cases). The treatment group received the manual reduction combined with percutaneous vertebral plasty, while the control group only received percutaneous vertebral plasty. Lumbar back pain VAS scores, vertebral anterior height and spine after convex Cobb angle before and after operation in the two groups were compared. Results There was statistical significance among VAS pain score, spine after convex Cobb angle and anterior flange height in the two groups (P<0.05); There was no statistical significance in VAS score in the two groups on the 2nd day. (P>0.05), while there was statistical significance in spine after convex Cobb angle and anterior flange height in the two groups (P<0.05);There was statistical significance among VAS pain score, spine after convex Cobb angle and anterior flange height in the two groups in the 3rd month after operation (P<0.05). Conclusion Manual reduction combined with percutaneous vertebral plasty can improve the lower back pain, restore vertebral body height and correct spine after contex Cobb angle of osteoporotic thoracolumbar compression fractures, which is better than pure percutaneous vertebral plasty.

Epithelial-mesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype.Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells.The process of EMT involves a number of signal transduction pathways,and is related to microRNAs,Helicobacter pylori,transcription factors and so on.EMT is expected to be a novel therapeutic target of gastric cancer.

Colorectal cancer(CRC) is kind of the common malignant tumor worldwide.Bad prognosis is always due to distal metastasis.In recent years,the research on chemokines targeted on cancer metastasis and directing on the movement of the tumor cells have been more and more deeply taken into consideration.Chemokine CXCL12 and its specific chemokine receptor CXCR4 play important roles in CRC cell's targeted cancer metastasis and directing movement by signal transduction mechanism.Researches showed that it can inhibit the migration and invasion of the tumor through interception chemokine receptor CXCR4 by many ways.The studies of this signal may be a potential target sit for gene therapy.The aim of this review was to summarize the current knowledge of these researches.

BACKGROUND: Decoy receptor 1 (DcR1), which acts as decoy receptors, is resistant to apoptosis induction by related apoptosis inducing ligand (TRAIL). OBJECTIVE: To investigate the expression of the DcR1 (TRAIL-R3) protein in human herniated and normal lumbar intervertebral discs (IVD). METHODS: The expression and distribution of DcR1 proteins were assessed by using immunohistochemistry in 20 herniated lumbar IVD and 8 normal lumbar IVD tissues samples following discoidectomy from January to September 2010. RESULTS AND CONCLUSION: Percentage of nucleus pulposus and anulus fibrous cells with DCR1 expression was obviously more in the herniated group than in normal IVD group. The current results indicate that the expression of DCR1 rises after herniation.

Purpose:To investigate the clinicopathological characristics of colorectal mucinous adenocarcinoma (MUC),which is generally bel ieved to have a poor prognosis,in an attempt to assess ways in which the surgica l outcome can be improved. Methods:From 1994 to 2003,1 715 large intestinal cancer patient s underwent operation, among them, 197 patients were with MUC. The clinicopathol ogical parameters and prognosis of MUC and non-MUC were analyzed retrospectivel y. Results:There were no significant differences in sex , tumor si te and size. Patients with MUC had higher rate of serosal invasion (MUC:59.9% vs non-MUC: 35.1%) , invasive type lymph-node involvement (MUC:41.6% vs non-MUC 21.6%). Patients with MUC were of more advanced stage(D stage:MUC :44.1% vs non-MUC: 22.1%). Conclusions:Based on these findings , a more aggressive attitud e toward surgical intervention is recommended , including extensive lymph node d issection and the resection of adjacent organs that seems to be affected microsc opically , to improve the surgical outcome of this clinical entity.

Objective To evaluate the use of ductography.Method A review of 51 patients with presenting complaints of nipple discharge from January 1998 to May 2000 was conducted. Pathology and ductograms were reviewed.Result Ductography had a definite value in the diagnosis of nipple discharge, the sensitiveity was 84.3%.Conclusion Ductography had value to locate and identify leisions, especially multiple leisions and leisions in the periphery of the breast, but it did not exclude pathology.

Objective To investigate the clinical significance of preoperative three-dimensional CT scan parameters to restore postoperative limb length and reduce postoperative dislocation in patients with total hip arthroplasty (THA).Methods Clinical data of two groups involving 86 cases that had primary unilateral THA were included.In study group 45 cases were operated on with the measurement of contralateral acetabular anteversion, acetabular abduction angle, distance from femoral neck osteotomy to the center of rotation of the femoral head and distance from femoral trochanter tip to the center of rotation based on three-dimensional CT scan.Another 41 cases under conventional surgery which not used these parameters served as control.Surgical efficacy was compared to verify the role of CT scan parameters in restoring postoperative limb length and reducing postoperative dislocation.Results Period of follow-up was (11.2 ± 6.2) months in study group and (11.6 ± 6.2) months in control group.Harris hip score in study group was (87.2 ± 5.4) points versus (80.9 ± 7.9) points in control group three months after operation (P ＜ 0.05).Limb length discrepancy in study group was (0.4 ± 0.2) cm versus (1.1 ± 0.4) cm in control group (P ＜ 0.05).Each group had one dislocation three months after operation.Conclusion The parameter measurement with three-dimensional CT scan has some guiding significance in THA.