1.Intervenient study of mental health in hypertension
Junzhi NI ; Hong SUN ; Jijing YU
Chinese Journal of Behavioral Medicine and Brain Science 2001;10(3):208-209
Objective To promote the therapeutic effect about the primary hypertension connected psychological factor through interventing anxiety emotion.Method All primary hypertension patients with anxiety emotion were divided into two groups randomly.Each group was treated by lotension for 8 weeks,While group 1 combined antianxiety drugs Deanxit Result The effective rate of two groups were 93.94%(group 1), 60.61%(group 2).Conclusion The therapeutic effect of group 2 is lower than that of group 1.
2.Synthesis of peptide fragment of melittin and the function of rheumatoid arthritis cure.
Meili YU ; Yong WANG ; Xiaohua LI ; Shuchang FANG ; Junchen XUE ; Jijing SONG
Journal of Biomedical Engineering 2005;22(5):1031-1035
To retain the anti-rheumatoid arthritis activity of melittin and to reduce the hemolysis and hypersusceptibility caused by melittin, a deletion peptide of melittin was synthesized. Its ant-inflammation effect was observed . A hydrophile peptide fragment of melittin was synthesized by standard solid-phase method. The product was analyzed by HPLC and MS. The relevant hemolysis and hypersusceptibility were tested. The rabbits' model of immune arthritis were established and treated. The results showed that the hemolysis rate for peptide fragment was less than 5%, the hypersusceptibility rate was less than 8%. The hydrophile peptide fragment of melittin may retain anti-rheumatoid arthritis activity and reduce the melittin-induced hemolysis and hypersusceptibility.
Animals
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Arthritis, Rheumatoid
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therapy
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Melitten
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chemical synthesis
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therapeutic use
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Peptide Fragments
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chemical synthesis
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therapeutic use
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Rabbits