Objective: To evaluate the significance of occlusion of hemihepatic inflow plus major ipsilateral hepatic veins in anatomic hepatectomy. Methods: One hundred and two cases were divided into 3 groups for anatomic hepatectomy: Group A (hemihepatic inflow plus major hepatic vein occlusion, n=42), Group B (hemihepatic inflow occlusion, n=30)and Group C (Pringle maneuver, n=30). The amount of intraoperative bleeding, time of operation, postoperative liver function, liver function recovering and complications were compared. Results: The average amount of hemorrhage in Group A, Group B and Group C were(453.5?87.9)、(612.8?101.6)and(646.7?136.6)mL, respectively. The mean blood loss in Group A was significantly more than that in Group B and Group C (P0.05). The levels of serum alanine transaminase (ALT)and bilirubin of 3rd and 6th day of postoperation in Group A and Group B were significantly lower than that in Group C, while the level of serum albumin in Group A and Group B was significantly higher than that in Group C(P0.05). Incidence of ascites in Group C was significantly higher than in Group A and Group B (P