2.Diagnostic value of MR mammography in breast ductal carcinoma
Journal of Jilin University(Medicine Edition) 2006;0(03):-
Objective To study the diagnostic value of MR mammography(MRM) in judging the nature of breast disease.Methods 145 cases with breast disease were retrospectively studied to investigate the relationships between two parameters(early-phase enhancement rate and the type of the delayed enhancement) and different breast diseases.All patients underwent MRM examination before surgical operation.Results ①Strengthen multiple in early stage larger than 3 times was inclined to malignant lesion;Strengthen multiple smaller than 1 time was inclined to benign lesion.②Drop type of delayed enhancement was the important parameter in diagnosis of ductal carcinoma.If drop type of delayed enhancement was viewed as the diagnosis standard of the ductal carcinoma of breast only:81% cases with invasive type of the ductal carcinoma,65% cases with noninvasive type of the ductal carcinoma had been diagnosed correctly;14% cases with benign breast lesions had been diagnosed exaggeratedly.③If strengthen multiple in early stage larger than 2.5 times in rising type of delayed enhancement and drop type of delayed enhancement was viewed as the diagnosis standard of the ductal carcinoma of breast,87.9% cases with invasive ductal carcinoma,73.1% cases with noninvasive ductal carcinoma had been diagnosed correctly;21.4% cases within benign breast lesions had been diagnosed exaggeratedly.Conclusion Compared with differential of disease nature by the type of the delayed enhancement only,the correct rate of diagnosis of breast ductal carcinoma mentioned above is raised if two parameters are combined.But the correct diagnosis rate of benign lesions is decreased.
3.Tumor necrosis factor-? regulates the effect of glutamine on protein synthesis in rats' skeletal muscle
Journal of Medical Postgraduates 2003;0(10):-
Objective:To find the regulations of glutamine(Gln) metabolism by tumor necrosis factor-?(TNF-?).Methods:Thirty male SD rats were assigned into three groups: A(total parenteral nutrition,TPN),B(TPN+Gln),C(TPN+ TNF-?+Gln).Besides all rats were supported by isonitrogenous and isocaloric TPN solutions for 3 days,rats in group B were supplied with Gln(in the form of alanylglutamine) for 3 days at the rate of 0.3 g/(kg?d),rats in group C were infused intravenously with TNF-? at the rate of 5 ?g/(kg?h) within the last 24 hours and also supplemented with Gln for three days at the same rate as in group B.At the last 0.5 hour,all animals were mainlined with \leucine at the dosage of 1.0 mmol/kg.TNF-? levels in plasma,concentrations of Gln in plasma and skeletal muscle were measured as the experiment ended after 72 hours,and the fractional synthesis rate(FSR) were also assessed.Results:The Gln concentrations in plasma and skeletal muscle increased markedly from group A,B to C.The levels of FSR decreased remarkably along with the sequence from group B,C to A.The statistical differences were significant(P
4.Prevention of early stage pulmonary complications in old patients following thoracic surgery
Journal of Medical Postgraduates 2003;0(03):-
Objective: To explore the preventive measures for early stage pulmonary complications in old patients following thoracic surgery.Methods: We conducted psychotherapy,pulmonary infection control,training in breathing and instructions in expectorating phlegm in 127 old patients(over 70 years) undergoing thoracic surgery.Results: The patients experienced difficult expectoration on the first postoperative day because of increased sputum viscoelasticity,which was gradually improved later.Analgestic and mucokinetic measures produced intended results on the first three postoperative days,with significant improvement of sputum fluidity.And the concept of fast track surgery promoted the recovery of the patients.Conclusion: The preventive measures proved essential for the prevention of early stage pulmonary complications in old patients following thoracic surgery.
5.Infection with Pseudomonas aeruginosa after Brain Operation and Analysis of Drug Sensitivity
Chinese Journal of Nosocomiology 2006;0(06):-
OBJECTIVE To study the infection of Pseudomonas aeruginosa after brain operation and drug-sensitivity.METHODS The system of BBLCrystalTM MIND-Crystal identification and Chinese software were used to identify P.aeruginosa.Drug-sensitivity was performed by K-B methods in accordance with NCCLS.RESULTS Totally 261 specimens were isolated from 126 patients during Mar to Dec 2005.From them 99 strains of P.aeruginosa were detected from specimens of 38 patients.There were 50 strains from phlegm,20 strains from suction in trachea,6 strains from urethral catheterization,8 strains from vein catheter,and 15 strains from wound excretion.Seventy seven strains(77.7%)were isolated during the peak period of May to August.Strains that were isolated in the same period possessed uniform drug-sensitivity results,which hinted epidemic of the same clone of P.aeruginosa in the Deparment of Cerebral Surgery.Drug-sensitivity results showed P.aeruginosa had been resistant to the common antibiotics.CONCLUSIONS Infection with P.aeruginosa after brain operation and drug resistance have already been serious,so we should think seriously of it.
6.Drug-resistance Status of Klebsiella pneumoniae in County Hospital
Chinese Journal of Nosocomiology 2004;0(10):-
OBJECTIVE To investigate drug-resistance status of Klebsiella pneumoniae in county hospital and provide the reference for rational application of antibiotics.METHODS Drug-resistance was analyzed by K-B methods.The ESBLs producing strains were detected by disc confirmed test.RESULTS The detection rate of ESBLs producing K.pneumoniae was 34.7% in our hospital.Among 216 strains of K.pneumoniae,the susceptibility rates to imipenem and meropenem were all 100.0%.And the resistant rate to amikacin was 25.0%.The resistant rates to the other 9 antibiotics were all over 30.0%.CONCLUSIONS Drug-resistance status of K.pneumoniae is very serious in county hospital.We should think highly of monitoring and controlling drug-resistance of clinical strains in order to prevent breaking out and surveillance.
7.Investigation of idiopathic macular hole formation in the elderly patients
Chinese Journal of Geriatrics 2000;0(06):-
Objective To investigate the characteristics of process of the formation of idiopathic macular hole, measurement was made for the patients using optical coherence tomography (OCT). Methods OCT was performed in 55 eyes of 40 cases (40 initially diseased eyes and 15 contralateral eyes). Results OCT images showed that among the 40 initially diseased eyes the number of macular hole of 1, 2, 3 and 4 stages was respectively 1, 11, 23 and 5 eyes. The depth of fovea of eye of stage 1 was 331 ?m. The average diameters of the macular holes in stage s 2, 3 and 4 were respectively 298.1 ?m, 681.2 ?m and 557.5 ?m. Ten out of the 15 contralateral eyes were observed with macular hole (stage 1 and 2 were 6, 3 eyes respectively and lamellar hole was 1 eye). Separation of posterior vitreous was observed in 16 out of 55 macular holes eyes (account for 29%). OCT images showed that there were split and cystic space with separated vitreous centrally attached to the fovea in the case of stage 1. It was observed that the contracted operculum attached to post erior vitreous with an opening apart from the center in the case of stage 2. Stage 3 displayed a full-thickness hole with surrounding edema and stage 4 showed a full-thickness hole and a complete separation of the posterior vitreous from retina. Conclusions OCT can display clearly the size, shape and process of the formation of macular hole. It was observed that the initial changes in the vitreous detachment and fovea by investigation of the contralateral eyes. OCT is also a useful method for the diagnosis, study on the mechanisms of the formation of macular hole.
8.How to bring Community Health Institution into play
Chinese Medical Ethics 1994;0(06):-
The community health institution of our country can't take effect really because of some restrictive factors. We have analyzed the issue and the countermeasure in this paper.
9.On Doctors′ Practice in Different Medical Institutes in the Project of Medical Reform
Chinese Medical Ethics 1996;0(01):-
It is suggested to explore the practice of doctors at different edical institutes in the Project of Medical Reform in 2009.There will be a series of problems when the practice is carried out.The methods to solve these problems would be studied in the aspects of defining the nature of doctors′ practice at different medical institutes,improving system building and transferring conception.
10.Diagnostic value of colposcopy combined new thinprep pap test in cervical cytology precancerous lesions
Chinese Journal of Primary Medicine and Pharmacy 2011;18(14):1902-1903
Objective To evaluate the new colposcopy combined cytology thinprep pap test(TCT) in cervical screening in the diagnosis of disease. Methods 1 266 patients detected by gynecologic cervical cytology were conducted on colposcopy and liquid-based thin-layer cytology of the Joint Inspection. Results 1 266 cases in which seized 169 cases of abnormal cervical lesion detection rate of 13. 35%,abnormalities in cervical squamous intraepithelial lesions and 126 cases,accounting for 9.99%. The incidence of cervical intraepithelial lesions detected no difference between age groups was statistically significant(P>0.05). Conclusion Thinprep cytology combined colposcopy cervical precancerous lesions was a reliable method for early diagnosis.