1.Serum screening of celiac disease in Chinese adults with diarrhea-predominant irritable bowel syndrome in Hubei, China
Hongling WANG ; Linjie LUO ; Jiguang KOU ; Anlong YUAN ; Guifang YANG ; Min WANG ; Bing XIA
Chinese Journal of Internal Medicine 2013;(1):38-41
Objective To screen the prevalence of celiac disease with serologic markers in the central Chinese population,specifically in patients with chronic diarrhea-predominant irritable bowel syndrome (D-IBS).Methods A total of 282 adult patients with D-IBS were selected based on ROME Ⅲ criteria with 296 age and sex matched consecutive healthy individuals as controls.A gluten-free diet (GFD) was advised in subjects positive for IgA/IgG anti-htTG/DGP antibodies and the serologic antibodies were retested after the GFD.Results Among the 578 study subjects,five D-IBS patients (5/282,1.77%) and two healthy controls (2/296,0.68%) were positive for anti-htTG/DGP antibodies.Among the seven positive cases,one was lost to follow-up and only four were evaluated during GFD therapy for an average of 5.2 months with clinical and/or serological manifestations improved.Conclusions The prevalence of celiac disease may not be uncommon in China.Compared with the healthy population,patients with D-IBS tend to be affected more.Thus,it is significantly important to conduct routine screening for celiac disease in patients with D-IBS.
2.To Understand the Modulatory Effect of Probiotics on Irritable Bowel Syndrome
Anlong YUAN ; Peng LI ; Li WANG ; Bibo ZHONG ; Bin BAI ; Xiaoyu HUANG ; Jiguang KOU
Journal of Neurogastroenterology and Motility 2018;24(4):676-677
No abstract available.
Irritable Bowel Syndrome
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Probiotics