Objective To study the effects of resin absorptive devices combined with hemodialyzer in series treatment for patients with uremia.Methods Sixty maintenance hemodialysis patients with uremia were randomly divided into two groups: the experimental group and control group. The patients in experimental group were given the treatment for traditional hemodialysis two or three times a week,combined with the treatment for resin absorption twice a month.The patients in the control group were only given the treatment for traditional hemodialysis two or three times a week.The middle molecular substance(MMS),beta(2) microglobulin(?_2-MG),blood urea nitrogen,creatinine,albumin,globulin,the counts of red blood,hemoglobin,the change of blood pressure and clinical manifestation of the patients were observed before and three months after the treatment respectively.Results The rates of clearance of MMS and ?_2-MG were significantly higher in the experimental group than those of the control group(P