Objective To study the method and effectiveness of interruption of mother-to-child transmis-sion among human immunodeficiency virus (HIV)-infected women. Methods Clinical information of 110 cases of HIV-infected pregnant women who gave birth in the eighth municipal hospital of Guangzhou from June 2009 to June 2012 were retrospectively analyzed. Measures such as antiviral treatment , elective caesarean and artificial feeding were taken to interupt mother-to-child transmission , differences in pregnancy outcomes bewteen CD4 t-lymphocyte count > 200/μL and < 200/μL groups were compared , and whether the baby had HIV antibodies after 18 months of age was tested. Results Among 110 cases of HIV-infected pregnant women , 102 cases ac-cepted drugs block, the blocking rate was 92.72%, 106 cases accepted elective caesarean, the block rate was 96.36%, all of the 112 cases of newborns accepted artificial feeding , the block rate was 100%. The cases were divided into two groups according to CD4T lymphoma count: group 1 [ > 200 /μL ( 84 cases ) ] and group 2 [< 200/μL group (26 cases)]. In group 1, the rate of anemia, preterm and postpartum hemorrhage was lower than that of group 2; the rate of low birth weight and FGR was obviously lower than that of group 2. There was statisticsly significantly difference between the two groups. 112 infants were all aged 18 months , among those we regularly followed up 88 cases (78.58%) and no infants were HIV-infected. Conclusion Interruptions of moth-er-to-child transmission of HIV are important measures to control AIDS epidemic among children.